NACC YEARS 11 – 15

Specific Aims

To maintain and further develop the NACC database and facilitate its use for research, including:

Expanding the web-based data query capabilities and data analysis tools;

Refining existing data submission systems through the development of new internal data monitoring tools;

Providing database consultation to Alzheimer's Disease Center (ADC) Data Cores and investigators; and

Establishing and maintaining study-specific databases for NACC funded collaborative and external projects.


To continue and build upon the Uniform Data Set (UDS), data quality assurance and quality control procedures already in place, including:

Providing quality assurance for the UDS in terms of operational procedures, documentation, consultation and training;

Applying computerized data checks and statistical pattern monitoring to detect and correct errors;

Conducting audits of ADC data or procedures;

Sustaining attention on data quality issues through monthly data monitoring reports to ADCs and NIA; and

Monitoring responses to identified data issues through the Quality Assurance Issues Tracking System (QAITS).


To promote collaborative research among the ADCs through research funding and technical support, including:

Facilitating NIA sponsored collaborative research initiatives among the ADCs;

Providing competitive, peer-reviewed funding of investigator-initiated collaborative projects and junior investigator NACC data analysis projects;

Continuing to refine the web-based Potential Research Topic List and Tracking system; and

Providing database design/analysis consulting for all ADC investigators.


To develop new methodological tools and approaches relevant to research on Alzheimer's disease (AD) and related disorders, including:

Analysis of binary longitudinal data in multi-center studies with missing covariate values;

Verification bias in diagnostic test studies; and

Markov process models for disease progression accounting for clustering and age dependence.


To conduct descriptive and analytic studies of specific content areas from the NACC database; including:

Prognostic role of body mass index on cognition function and behavior in AD;

Diagnostic accuracy and use of a consensus diagnosis process;

Association between hearing impairment and rate of cognitive decline; and

Factors that predict dropout in the UDS.


To perform NACC's NIA-required administrative functions, including:

Providing logistical support for the directors' and core leaders' semi-annual meetings;

Interfacing with NIA initiative groups;

Distributing funds in support of NACC data collection effort and collaborative projects; and

Facilitating inter-ADC communication activities.