NACC’s genetics and imaging collaborations
NACC works in close collaboration with the Alzheimer's Disease Centers (ADCs), the National Cell Repository for Alzheimer's Disease (NCRAD), the Alzheimer's Disease Genetics Consortium (ADGC), and the NIA Genetics of Alzheimer's Disease Data Storage Site (NIAGADS) to advance GWAS efforts in Alzheimer's disease.
NACC, NCRAD, and the ADCs work together to track GWAS subjects and any DNA, blood, buffy coat, or brain tissue samples sent for genotyping. NACC shares limited phenotype data with ADGC and serves as a data repository from which each ADC may access its own genotype data.
Researchers wishing to gain access to comprehensive ADGC data must submit a proposal directly to ADGC or the NIA Genetics of Alzheimer's Disease Data Storage Site (NIAGADS). For more information on requesting data from NIAGADS and the ADGC, see this description provided by NIAGADS. For subjects in ADC studies, common IDs permit the GWAS data sets housed at ADGC and NIAGADS to be easily linked to UDS, NP, and MRI data from NACC.
Through a collaborative effort between NACC and the ADCs, MRI images from a subsample of UDS subjects are stored in the NACC database. ADCs submit MRIs to NACC as compressed archives of DICOM files, and these files are available to researchers by request. Planned collaborative efforts for the future will culminate in additional MRI data (i.e., intracranial, brain, and hippocampal volume), linked to UDS, FTLD, and NP data that will available to researchers through NACC. NACC has also begun collecting PET images linked to these data.
For more information, please visit our collaborators' websites: