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NACC research structural MRI

NACC MRI sample characteristics

MRI types






MRI data format*DICOM (.dcm) image files
MRI package format*.zip
Method of MRI collectionADCs voluntarily submit available images to NACC. Image-acquisition and data-collection protocols vary by ADC. Retrospective and prospective data collections is ongoing.
Image acquisition period2005 – present
SubjectsADC subjects enrolled in the Uniform Data Set (UDS)
Clinical diagnosesNormal cognition, MCI, dementia
Linked genotype dataAvailable from ADGC
Longitudinal MRIsAvailable for some subjects

*Please note that calculated volume data are not available at this time.


The NACC Research Structural MRI Database is a large, freely available sample of MRIs that are linked to the standardized UDS and NP data, as well as genotype data from ADGC.

MRIs at NACC are most appropriately described as a convenience sample of images, voluntarily submitted by several Alzheimer's Disease Centers. Imaging data collection and acquisition protocols vary by ADC; thus, packages of MRI files at NACC may include T1-weighted, FLAIR, DTI, T2, or other MR series (and any combination thereof), and subjects may or may not have multiple scan sessions in the NACC database.


Accessing MRI image files

TO VIEW A SAMPLE OF MRIs meeting specified image and subject criteria:

NACC's MRI query system

Available data:

Researcher requirements:


• Sample size estimation:

 – Number of MRI files meeting criteria

 – Number of unique UDS subject IDS meeting criteria

• Links to download a sample of 10 or fewer MRIs meeting criteria


Email address

Acknowledgment of NACC's
 confidentiality agreement

Visualization software

TO REQUEST IMAGE FILES for analysis and publication purposes:

NACC data file request

Available data:

Researcher requirements:


"Packages" of DICOM MRIs archived by subject ID and MRI date (.zip), delivered via secure file transfer protocol (sFTP) and linked to any requested UDS, FTLD, or NP data.

Note: Additional image types not requested may be included in the package.


Email address

Proposal title

Brief project description
 and specific aims

Acknowledgment of NACC's
 confidentiality agreement

Visualization software


Anyone may access a sample of MRI files at NACC through NACC's MRI Query System; however, to open and view the images, visualization software is required. Many software packages are available on the web as freeware or free trials and can be located by doing a web search for "DICOM viewer."

Please note that to download images for analysis and publication purposes, a more detailed data request is required.