The UDS3 Crosswalk Study

STUDY DOCUMENTATION

Following are the revised study PDFs, with a description of their contents. Only documentation labeled "Official Data Collection Version" should be used to gather data for this study.

Form C1W
  • The summary scores form to be used in submitting crosswalk data to NACC
Form C1W and worksheets
  • The summary scores form to be used in submitting crosswalk data to NACC
  • The worksheets to be used in administering the six tests
Form C1W and worksheets, plus stimuli
  • The summary scores form to be used in submitting crosswalk data to NACC
  • The worksheets to be used in administering the six tests
  • The picture stimuli needed for the MINT
Instructions for test administration
  • Complete test administration instructions

STUDY DESIGN AND PROTOCOL

What tests to give: Both the current UDS neuropsychological battery and the Crosswalk tests must be administered to the same individual at that participant's UDS visit.

What order to give them in: Administration order has been assigned at the Center level. Center assignment lists can be accessed here.

How many and which subjects to include: Each participating ADC should plan to administer the test to all able subjects making both initial and follow-up visits. In addition to cognitively normal individuals, persons across a range of dementia severity are desired; all dementia etiologies are acceptable. The proposed per-ADC distribution is as follows:

      

It is recognized that some ADCs may not be able to fulfill all cells of the proposed distribution. However, if all ADCs contribute close to 60 participants, it precludes some Centers having to shoulder increased burden to make up for those who do not participate.

During the crosswalk, NACC will perform interim analyses to monitor progress.

STUDY BACKGROUND

The Crosswalk Study is being conducted in order to establish the equivalency of new neuropsychological tests proposed for UDS3 with the UDS2 tests they will replace.

NACC is preparing Version 3 of the UDS for implementation soon in the ADCs. An important aspect of UDS3 is the revamped neuropsychology battery. The new battery features nonproprietary measures that replace the proprietary measures in the original neuropsychological battery (the few nonproprietary measures in the original battery will remain in the new battery). The Neuropsychology Work Group of the Clinical Task Force believes that the new nonproprietary measures in the UDS3 battery will yield cognitive data equivalent to the proprietary measures that they replace, and this study has been designed to establish that equivalency.

All ADCs are encouraged to participate in this study. Unfortunately, no funds are available to support the crosswalk study, nor for necessary preparations such as seeking Institutional Review Board approval, so site participation is entirely voluntary.


STUDY ANNOUNCEMENT, September 24, 2013