Biomarker and imaging data sets

Supplemental data for a subset of UDS subjects

NACC has developed a series of data dictionaries to aid in the analysis of our biomarker and imaging data. The variables described in the data dictionaries listed below may supplement data requests for UDS, FTLD, and NP data.

Imaging and biomarker data at NACC are most appropriately described as a convenience sample, voluntarily submitted by several Alzheimer’s Disease Centers (ADCs). There is no defined data collection period, and there are no submission deadlines for imaging and biomarker data; instead, images and other biomarker data are submitted at the discretion of the individual ADCs.

RDD-ID button

The Researcher’s Data Dictionary — Imaging Data (RDD-ID) includes MRI and PET variables (e.g., year of MRI scan, year of amyloid PET scan) associated with DICOM files stored at NACC . Also included are MRI variables that provide volume values (e.g., hippocampal volume) for the subset of DICOM files stored at NACC for which volumetric analysis has been completed. Imaging data collection and acquisition protocols vary by ADC. Packages of MRI files at NACC may include T1-weighted, FLAIR, DTI, T2, or other MR series (and any combination thereof). Subjects may also have MRI or PET scans from multiple dates.

RDD-CSF button

The Data Element Dictionary — CSF (DED-CSF) includes includes data on UDS subjects who have CSF values for Abeta, P-tau, and T-tau. Please note that CSF assay methods are not standardized across the ADCs, and that some subjects may have CSF values from multiple dates.

RDD-Gen button

The Researcher’s Data Dictionary — Genetic Data (RDD-Gen) describes variables that contain either genetic data (APOE genotype) or information about the availability of genetic data that can be obtained, by request, from the Alzheimer’s Disease Genetics Consortium (ADGC), the National Institute of Aging Genetics of Alzheimer’s Disease Data Storage Site (NIAGADS), or the Database of Genotypes and Phenotypes (dbGaP).

 

Data dictionaries for other biomarkers are being developed. Please check back soon.