Research Using the NACC Database

The Placebo Group Simulation Approach (PGSA): Predicting Decline in Patients

   Lead Investigator:    Rene Spiegel
   Institution      :    Memory Clinic, Geriatric University Hospital
   E-Mail           :
   Proposal ID      :    109

Publications: 1 Spiegel R It really works! Confirmation of the ADNI-based Placebo Group Simulation Approach with NACC data Abstract Alzheimers Dement,7:e64,2011,
2 Spiegel R, Berres M, Monsch A, Miserez A, Kukull WA Validating the Placebo Group Simulation Approach (PGSA), an Alternative Study Design for Preventive Trials in Prodromal AD Patients Abstract Alzheimers Dement,10:P859,2014,
3 Spiegel R, Berres M, Miserez AR, Monsch AU The Placebo Group Simulation Approach (PGSA): An Alternative Study Design for Clinical Trials in Patients with Prodromal AD 2011 Abstract CTAD Conference, San Diego November 3-5 ,
4 Spiegel R Modeling the Course of AD: Contributions to Better Clinical Trials 2012 Abstract J Nutr Health Aging 811-812 ,
5 Berres M, Kukull WA , Miserez AR, Monsch AU, Monsell SE , Spiegel R A Novel Study Paradigm for Long-term Prevention Trials in Alzheimer Disease: The Placebo Group Simulation Approach (PGSA). Application to MCI data from the NACC database Journal Article J Prev Alzheimers Dis,1:99-109,2014,PMC4268776

Proposal Description:
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NACC is funded by the National Institute on Aging (UO1 AG016976) and located in the Department of Epidemiology at the University of Washington School of Public Health, Walter A. Kukull, Ph.D., Director. Copyright© 2010 University of Washington.