Research Using the NACC Database

Clinicopathologic correlation in FTLD

 
   Lead Investigator:    Aditi Joshi
   Institution      :    UCLA
   E-Mail           :    aditi.draditi@gmail.com
   Proposal ID      :    164


   Publications:


1  Joshi A, Teng E, Tassniyom K, Mendez MF
   Hippocampal and mesial temporal sclerosis in early-onset frontotemporal lobar degeneration versus Alzheimer's disease
   Journal Article  Am J Alzheimers Dis Other Demen,29:45-49,2014,PMC3947801

   PUBLISHED



2  Joshi A, Teng E, Tassniyom K, Shapira JS, Mendez MF
   Hippocampal and medial temporal sclerosis in behavioral variant frontotemporal dementia
   Abstract  Neurology,80:S44.007,2013,

   PUBLISHED



3  Mendez M, Joshi A, Tassniyom K, Teng E
   Clinicopathological differences among patients meeting clinical criteria for behavioral variant frontotemporal dementia
   Abstract  Dement Geriatr Cogn Disord,34 (Suppl 1):260-261,2012,

   PUBLISHED



4  Mendez MF, Joshi A, Tassniyom K, Teng E, Shapira JS
   Clinicopathological Differences Among Patients with Clinical Behavioral Variant Frontotemporal Dementia
   Journal Article  Neurology,80:561-568,2013,PMC3589292

   PUBLISHED





   Proposal Description:
   Frontotemporal dementia (FTD) is one of the most common cause of early-onset      dementia. Behavioral variant FTD or bvFTD represents the most common subtype of   FTD. The accuracy of this diagnostic criteria is still uncertain. Nevertheless,   the old criteria for diagnosis has been utilized for greater than ten years       with limitations. Recently a new International consensus criteria for bvFTD       diagnosis has been established during the April 2011 American Association of      Neurology (AAN) Conference. Due to its relatively recent introduction, this       criteria has not been studied as extensively. The aim of this study is to         review proven cases of FTD pathology from the NACC database. Neuropathological    diagnosis in the form of postmortem tissue analysis will be the gold standard     for comparison. All cases of autopsy-proven FTD will be reviewed and correlated   with neuropsychiatric symptoms of patients. Neuropsychiatric symptoms include     symptoms of emotion, social awareness, disinhibition, stereotype behavior and     impulsivity. This study will be useful by allowing researchers to gain more       confidence in the diagnosis of this difficult condition.