Effect of mixed neuropathologies on profile and cognitive change in dementia

 
   Lead Investigator:    Jon Toledo
   Institution      :    CNDR, UPenn School of Medicine
   E-Mail           :    jtoledo@mail.med.upenn.edu
   Proposal ID      :    188


   Publications:


1  Toledo JB, Arnold SE, Brettschneider J, Lee EB, Xie SX, Grossman M,  Monsell SM, Kukull WA , Trojanowski JQ
   Importance of coincident neurodegenerative diseases
   Abstract  Alzheimers Dement,9:P334,2013,

   PUBLISHED





   Proposal Description:
   The objective of this study is to analyze:  1) How the phenotype and clinical characteristics of AD patients are modified when other neurodegenerative diseases, vascular disease, and hippocampal sclerosis are present.  2) Describe how the presence of a secondary neuropathological diagnosis (in addition to AD) modifies the progression of disease  3) Analyze if some of the different neuropathological diseases, vascular diseases or hippocampal sclerosis co-occur more frequently than others.  4) How do known genetic risk factors affect the co-occurance and the phenotype of these disease.