Research Using the NACC Database

Evaluation of the Neuropathologic Cerebrovascular Sequelae of Antipsychotic Use
  
   Lead Investigator:    Erin Abner
   Institution      :    University of Kentucky
   E-Mail           :    elabne0@uky.edu
   Proposal ID      :    231


   Publications:


1  Jicha G, Nelson P, Fardo D, Kryscio R, Schmitt F, Smith C, Neltner J, Van Eldik L,  Kukull W , Abner E
   Vascular neuropathology in dementia patients receiving antipsychotic therapy
   Abstract  Alzheimers Dement,9:P303,2013,

   PUBLISHED





   Proposal Description:
   A 2006 FDA-issued black box warning was issued in 2006 indicating indicated that older adult patients with dementia treated with antipsychotics are at an increased risk of death, primarily from vascular complications (myocardial infarction and stroke) and infections (pneumonia). Despite the profound impact this warning has had on the field, the cerebrovascular consequences of antipsychotic use in dementia remain poorly understood. Older adults diagnosed with dementia who came to autopsy will be assessed with regard to clinical characteristics, medical history, medication use, and neuropathologic vascular burden to determine whether there are differences in observed pathology associated with use of antipsychotic agents.