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NON-NACC DATA SETS from R01 and U01 studies

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Research Using the NACC Database

Elevated pulse pressure (PP), cognitive impairment and decline, and vascular
and AD neuropathology
 
   Lead Investigator:    Lilah Besser
   Institution      :     
   E-Mail           :    lmbesser@uw.edu
   Proposal ID      :    249


   Publications:



1  Besser LM, Hawes SE, Bristow KE, Monsell SE, Kukull WA
   Pulse Pressure and Atherosclerosis, Arteriolosclerosis, and Cortical Microinfarcts in Individuals with Clinical Alzheimer?s Disease.
   2013   Abstract  Alzheimers and Dementia   9   P441

   PUBLISHED





   Proposal Description:
   Aim 1: Among those with MCI (amnestic or non-amnestic): 1a) To assess whether elevated PP observed over greater or equal 2 visits is associated with greater cognitive decline compared to those with normal PP at all visits. Possibly restricting exposed group to those with elevated PP and normal BP at 2 visits. 1b) To evaluate whether elevated PP observed over greater than or equal 2 visits is associated with higher impairment as measured through the CDR memory box, orientation box, or judgment/problem solving box scores at the second visit with an abnormal PP reading. 1c) To explore possible interactions/mediation by reported history of hypertension, abnormal blood pressure measurements, and antihypertensive use.  Aim 2: Is elevated PP among those with a clinical diagnosis of MCI/probable AD dementia associated with a greater frequency/severity of vascular or AD pathology?