Research Using the NACC Database

A liability model to increase power in genome-wide association

 
   Lead Investigator:    Jesse Mez
   Institution      :    Boston University Alzheimer's Disease Center
   E-Mail           :    jessemez@bu.edu
   Proposal ID      :    407



   Proposal Description:
   We hypothesize that using a quantitative phenotype derived from a liability model that includes clinical and genetic covariates will allow us to detect additional SNPs that contribute to incidence of AD. Given our success using this approach in a smaller African American dataset, we propose 1) to carry out   genome-wide association in ADGC African American cases and controls using residuals from a liability model as a quantitative phenotype. If this approach proves successful, we propose 2) to take the same approach in ADGC white cases and controls.