NACC Research Productivity - last update 5/18/2015
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Research Utilizing NACC Data: (TOTAL of 462)

       Publications
         2015
1.   Barnes J, Dickerson B, Frost C, Jiskoot LC, Wolk D, van der Flier WM. Alzheimer's disease first symptoms are age dependent: Evidence from the NACC data set. Alzheimers and Dementia, in press 2015, PMC in process.

2.   Beecham GW, Dickson DW, Scott WK, Martin ER, Schellenberg G, Nuytemans K, Larson EB, Buxbaum JD, Trojanowski JQ, Van Deerlin VM, Hurtig HI, Mash DC, Beach TG, Troncoso JC, Pletnikova O, Frosch MP, Ghetti B, Foroud TM, Honig LS, Marder K, Vonsattel JP, Goldman SM, Vinters HV, Ross OA, Wszolek ZK, Wang L, Dykxhoorn DM, Pericak-Vance MA, Montine TJ, Leverenz JB, Dawson TM, Vance JM. PARK10 is a major locus for sporadic neuropathologically confirmed Parkinson disease. Neurology, 84:972-980, 2015, PMC4352096.

3.   Brenowitz WD, Nelson PT, Besser LM, Heller KB, Kukull WA. Cerebral amyloid angiopathy in Alzheimer's disease and other vascular brain pathology. Alzheimer's & Dementia, submitted 2015.

4.   Brown DS, Hynan LS, Weiner M, Lacritz LH, Minhajuddin A. Relationship of Metabolic Syndrome to Rate of Cognitive Decline in Normal Controls Mild Cognitive Impairment and Alzheimer's Disease. 43rd Annual International Neuropsychological Society Meeting, accepted 2015. (Abstract)

5.   Burke SL, Maramaldi P, Cadet T, Kukull W. Associations between depression, sleep disturbance and Apolipoprotein E in the development of Alzheimer's disease: dementia. Gerontologist, submitted 2015.

6.   Burke SL. Decreasing hazards of Alzheimer's disease with the use of antidepressants: An analysis of generic drugs. AAIC 2015, submitted 2015. (Abstract)

7.   Callahan BL, Duchesnea S, Black SE. Vasculopathological characteristics of neuropsychologically-derived subgroups of mild cognitive impairment and dementia. Alzheimer's Association International Conference 2015, submitted 2015. (Abstract)

8.   Caselli RJ, Dueck AC, Locke DE, Baxter LC, Woodruff BK, Geda YE. Sex-Based Memory Advantages and Cognitive Aging: A Challenge to the Cognitive Reserve Construct?. J Int Neuropsychol Soc, in press 2015, PMC in process.

9.   Chen B, Zhou XH, Chan KC. Pseudo-empirical Likelihood-Based Method Using Calibration for Longitudinal Data with Drop-Out. J Royal Stat Soceity Series C, 64:157-174, 2015, PMC4288856.

10.   Chung EJ, Babulal GM, Monsell SE, Cairns N, Roe CM, Morris JC. Clinical features of Alzheimer disease with Lewy body pathology. JAMA Neurology, submitted 2015.

11.   Chung EJ, Babulal GM, Monsell SE, Cairns NJ. Clinical features of Alzheimer disease with and without Lewy body pathology. AAIC 2015, submitted 2015. (Abstract)

12.   Clem MA, Pandya SY, Holliday RH, Lacritz LH, Woon FL. Baseline Neuropsychiatric Symptoms and Stability of Mild Cognitive Impairment. 43rd annual meeting of the International Neuropsychological Society, Denver, CO, 2015. (Abstract)

13.   Deutsch MB, Mendez MF, Teng E. Interactions between traumatic brain injury and frontotemporal degeneration. Dement Geriatr Cogn Disord, 39:143-153, in press 2015, NIHMS642702.

14.   Forrester SN, Gallo JJ, Smith GS, Leoutsakos JS. Patterns of Neuropsychiatric Symptoms in MCI and Risk of Dementia. American Journal of Geriatric Psychiatry, revision 2015.

15.   Gavett B. Rethinking Abnormal Test Scores in Normal People: Application of Base Rate Data to the Individual Patient. National Academy of Neuropsychology, submitted 2015. (Abstract)

16.   Gavett BE, Vudy V, Jeffrey M, John SE, Gurnani A, Adams J. The delta latent dementia phenotype in the uniform data set: Cross-validation and extension. Neuropsychology, 29:344-352, 2015, PMC4340822.

17.   Ghani M, Reitz C, Cheng R, Vardarajan BN, Jun G, Sato C, Naj A, Rajbhandary R, Wang L, Valladares O, Lin C, Larson EB, Graff-Radford NR, Evans D, De Jager PL, Crane PK, Buxbaum JD, Murrell JR, Raj T, Ertekin-Taner N, Logue M, Baldwin CT, Green RC, Barnes LL, Cantwell LB, Fallin D, Go RCP, Griffith P, Obisesan TO, Manly JJ, Lunetta KL, Kamboh MI, Lopez OL, Bennett DA, Hendrie H, Hall KS, Goate AM, Byrd GS, Kukull WA, Foroud TM, Haines JL, Farrer LA, Pericak-Vance MA, Lee JH, Schellenberg GD, George-Hyslop PS, Mayeux R, Rogaeva E, ADGC Collaborators. Association of Long Runs of Homozygosity with Alzheimer's Disease among African Americans. JAMA Neurology, submitted 2015.

18.   Gifford KA, Liu D, Hohman TJ, Xu M, Han X, Romano III RR, Abel T, Jefferson AL. The source of cognitive complaints differentially correlates with neuropathologicaloutcomes in mild cognitive impairment. Brain, submitted 2015.

19.   Hassenstab J, Monsell SE, Mock C, Roe CM, Cairns NJ, Morris JC, Kukull W. Neuropsychological markers of cognitive decline in persons with Alzheimer's disease neuropathology. Neurology, submitted 2015.

20.   Hill BD, Sofko C, Thaler N, Gavett BE. Cognitive Intra-Individual Variability Increases with Neuropathological Burden and Clinical Dementia Rating Score. Neuropsychologia, submitted 2015.

21.   Hohman TJ, Samuels L, Liu D, Gifford KA, Mukherjee S, Benson EM, Abel T, Ruberg FL, Jefferson AL. Stroke Risk Interacts with Alzheimer's Disease Biomarkers on Brain Aging Outcomes. Neurobiol Aging, submitted 2015.

22.   Hsiao JJ, Lu PH, Grill JD, Teng E. Longitudinal declines in instrumental activities of daily living in stable and progressive mild cognitive impairment. Dement Geriatr Cogn Disord, 39:12-24, 2015, PMC4312538.

23.   Ighodaro ET, Abner EL, Monsell SE, Kukull WA, Nelson PT. Decoding the Risk Factors and Cognitive Consequences of a Common Vascular Pathology: Brain Arteriolosclerosis. AANP 2015, submitted 2015. (Abstract)

24.   Jefferson AL, Hohman TJ, Liu D, Haj-Hassan S, Gifford KA, Benson EM, Skinner JS, Lu Z, Sparling J, Sumner EC, Bell S, Ruberg FL. Adverse vascular risk is related to cognitive decline in older adults. J Alzheimers Dis, 44:1361-1373, 2015, PMC4336578.

25.   John, SE. Use of the Latent Dementia Phenotype for Differential Diagnosis in the NACC UDS. National Academy of Neuropsychology, submitted 2015. (Abstract)

26.   Jun G, Ibrahim-Verbaas CA, Vronskaya M, Lambert JC, Chung J, Naj AC, Kunkle BW, Wang LS, Bis JC, Bellenguez C, Harold D, Lunetta KL, Destefano AL, Grenier-Boley B, Sims R, Beecham GW, Smith AV, Chouraki V, Hamilton-Nelson KL, Ikram MA, Fievet N, Denning N, Martin ER, Schmidt H, Kamatani Y, Dunstan ML, Valladares O, Laza AR, Zelenika D, Ramirez A, Foroud TM, Choi SH, Boland A, Becker T, Kukull WA, van der Lee SJ, Pasquier F, Cruchaga C, Beekly D, Fitzpatrick AL, Hanon O, Gill M, Barber R, Gudnason V, Campion D, Love S, Bennett DA, Amin N, Berr C, Tsolaki M, Buxbaum JD, Lopez OL, Deramecourt V, Fox NC, Cantwell LB, Tarraga L, Dufouil C, Hardy J, Crane PK, Eiriksdottir G, Hannequin D, Clarke R, Evans D, Mosley TH, Jr., Letenneur L, Brayne C, Maier W, De Jager P, Emilsson V, Dartigues JF, Hampel H, Kamboh MI, de Bruijn RF, Tzourio C, Pastor P, Larson EB, Rotter JI, O'Donovan MC, Montine TJ, Nalls MA, Mead S, Reiman EM, Jonsson PV, Holmes C, St George-Hyslop PH, Boada M, Passmore P, Wendland JR, Schmidt R, Morgan K, Winslow AR, Powell JF, Carasquillo M, Younkin SG, Jakobsdottir J, Kauwe JS, Wilhelmsen KC, Rujescu D, Nothen MM, Hofman A, Jones L, Haines JL, Psaty BM, Van Broeckhoven C, Holmans P, Launer LJ, Mayeux R, Lathrop M, Goate AM, Escott-Price V, Seshadri S, Pericak-Vance MA, Amouyel P, Williams J, van Duijn CM, Schellenberg GD, Farrer LA. A novel Alzheimer disease locus located near the gene encoding tau protein. Mol Psychiatry, in press 2015, NIHMS654371.

27.   Kansal K. Comparative utility of psychometric tasks over the course of frontotemporal dementia. 2015 IPA International Congress, submitted 2015. (Abstract)

28.   Kansal K. Longitudinal comparisons of global measures of cognitive, behavioral and functional decline in frontotemporal dementia. 2015 IPA International Congress, submitted 2015. (Abstract)

29.   Leoutsakos JS, Forrester SN, Lyketsos CG, Smith GS. Latent classes of neuropsychiatric symptoms in NACC controls and conversion to MCI or dementia. Alzheimer's & Dementia, submitted 2015.

30.   Leoutsakos JS. NPS in normal cognition and the risk of developing MCI and dementia in the presence of late onset NPS. AAIC 2015, submitted 2015. (Abstract)

31.   Lin A, Paholpak P, Zhang JY, Teng E, Jimenez E, Mendez MF. PREVALENCE OF TRAUMATIC BRAIN INJURY IN EARLY VERSUS LATE-ONSET ALZHEIMER'S DISEASE. J Alzheimers Dis, submitted 2015.

32.   LoBue C, Clem M, Wilmoth K, Lacritz L, Woon FL, Rossetti HC, Cullum CM. Traumatic Brain Injury is Associated with Earlier Age of Diagnosis in Mild Cognitive Impairment Regardless of Gender. National Academy of Neuropsychology, submitted 2015. (Abstract)

33.   LoBue C, Denney D, Hynan LS, Rossetti HC, Lacritz LH, Hart Jr. J, Womack KB, Cullum CM.. Self-Reported Head Injury and Mild Cognitive Impairment: Increased Risk and Earlier Age of Diagnosis. Alz Disease Assoc Disorders, submitted 2015.

34.   LoBue C, Lacritz LH, Rossetti HC, Hart J, Womack KB, Cullum CM. Self-reported head injury and age of diagnosis in dementia. 43rd Annual International Neuropsychological Society Meeting, accepted 2015. (Abstract)

35.   LoBue C, Wilmoth K, Cullum CM, Rossetti HC, Lacritz LH, Hynan LS, Hart J, Womack KB. Traumatic Brain Injury History is Associated with Earlier Age of Onset in Frontotemporal Dementia. Journal of Neurology, Neurosurgery & Psychiatry, submitted 2015.

36.   Masters MC, Morris JC, Roe CM. "Noncognitive" symptoms of early Alzheimer disease. A longitudinal analysis. Neurology, 84:617-622, 2015, PMC4335988.

37.   Moga DC, Gnjidic D, Jicha G. Sex-specific Associations for Predicting Psychotropic Drug Use in Older Adults with Cognitive Impairment. Pharmacoepidemiology and Therapeutic Risk Management, submitted 2015. (Abstract)

38.   Moga DC, Wu Q, Gnjidic D, Jicha G. Sex-differences Pertaining to Diagnosis and Treatment of Dementia: a USA Perspective. Gerontological Society of America (GSA) Meeting, November, submitted 2015. (Abstract)

39.   Monsell SE, Mock C, Fardo DW, Bertelson S, Cairns NJ, Roe CM, Morris JC, Goate A, Kukull WA. Genetic differences between symptomatic and asymptomatic persons with Alzheimer's disease neuropathologic change. AAIC 2015, accepted 2015. (Abstract)

40.   Monsell SE, Dodge HH, Zhou XH, Bu Y, Besser LM, Mock C, Hawes SE, Kukull WA, Weintraub S, Neuropsychology Work Group Advisory to the Clinical Task Force. Results from the NACC Uniform Data Set neuropsychological battery Crosswalk Study. Alzheimer's & Dementia, submitted 2015.

41.   Monsell SE, Hassenstab J, Mock C, Roe CM, Cairns NJ, Morris JC, Kukull WA. Neuropsychological markers of cognitive decline in persons with Alzheimer's disease neuropathology. AAIC 2015, accepted 2015. (Abstract)

42.   Monsell SE, Kukull WA, Roher AE, Maarouf CL, Serrano G, Beach TG, Caselli RJ, Montine TJ, Reiman EM. APOE4 carriers and non-carriers with the clinical diagnosis of Alzheimer's dementia and minimal amyloid plaques. JAMA Neurology, submitted 2015.

43.   Moulder KL, Monsell SE, Beekly D, Besser LM, Blennow K, Kukull W, Morris JC. Factors Influencing Lumbar Puncture Participation in Alzheimer Research. AAIC 2015, submitted 2015. (Abstract)

44.   Nelson PT, Wang WX, Partch AB, Monsell S, Valladares O, Ellingson SR, Wilfred BR, Naj AC, Wang LS, Kukull WA, Fardo DW. Reassessment of risk genotypes (GRN, TMEM106B, and ABCC9 variants) associated with hippocampal sclerosis of aging pathology. J Neuropathol Exp Neurol, 74:75-84, 2015, PMC4270894.

45.   Pandya SY, Clem MA, Horton DK, Lacritz LH, Woon FL. Predictors of Reversion from Mild Cognitive Impairment to Normal Cognition. 43rd annual meeting of the International Neuropsychological Society, Denver, CO, 2015. (Abstract)

46.   Ringman J, Monsell S, Nguyen A, Tung S, Zhou Y, Ng D, Vinters H. Prevalence of cerebral amyloid angiopathy on autopsy in autosomal dominant Alzheimer's disease. American Academy of Neurology, 2015, submitted 2015. (Abstract)

47.   Rochani HD, Vogel RL, Samawi HM, Linder DF. Explicit Estimates For Cell Counts and Modeling The Missing Data Indicators in Three-way Contingency Table by Homogeneous Log-linear Models. APHA 2015 conference, submitted 2015. (Abstract)

48.   Rochani HD, Vogel RL, Samawi HM, Linder DF. Explicit Estimates For Cell Counts and Modeling The Missing Data Indicators in Three-way Contingency Table by Homogeneous Log-linear Models. Statistical Methods in Medical Research, submitted 2015.

49.   Rosenberg PB, Han D, Leoutsakos JM, Rattinger GB, Stuart EA, Oh ES, Lyketsos CG. Psychotropic medication exposure and cognitive, functional, and neuropsychiatric outcomes in Alzheimer's Disease (AD). revision 2015.

50.   Sayegh P. Neuropsychological Language Tests in Dementia Diagnosis in English-Speaking Hispanic and Non-Hispanic White Outpatients. Appl Neuropsychol Adult, in press 2015, PMC in process.

51.   Serrano-Pozo A, Qian J, Monsell S, Betensky R, Hyman B. APOE2 is associated with milder clinical and pathological Alzheimer's disease. AAN 2015, accepted 2015. (Abstract)

52.   Serrano-Pozo A, Qian J, Monsell S, Betensky R, Hyman B. APOEε2 is associated with milder clinical and pathological Alzheimer's disease. Annals Neurology, in press 2015, NIHMS681652.

53.   Shinohara M, Kanekiyo T, Yang L, Linthicum D, Shinohara M, Fu Y, Price L, Penuliar MS, Wang M, Han X, Fryer J, Bu G. APOE2 protects against age-related memory decline: a clinical and pre-clinical evaluation. Annals Neurology, submitted 2015.

54.   Sposato LA, Ruiz Vargas E, Riccio PM, Toledo J, Trojanowski J, Hachinski V. Atrial Fibrillation in Patients with Neuropathological Diagnosis of Primary. AAN 2015, accepted 2015. (Abstract)

55.   Sposato LA, Vargas ER, Riccio PM, Toledo JB, Trojanowski JQ, Kukull WA, Cipriano LE, Nucera A, Whitehead SN, Hachinski V. Role of Atrial Fibrillation in Patients with Alzheimer's Disease. Circulation, submitted 2015.

56.   Stabler A, Harris K. Episodic story memory performance among older adults with Alzheimer's dementia and frontotemporal dementia. American Academy of Clinical Neuropsychology, submitted 2015. (Abstract)

57.   Stabler, A. Use of the Latent Dementia Phenotype for Differential Diagnosis in the NACC UDS. National Academy of Neuropsychology, submitted 2015. (Abstract)

58.   Tripodis Y. Rate of decline for AD patients with history of traumatic brain injury. AAIC 2015, submitted 2015. (Abstract)

59.   Tse KH, Cheng A, Chow HM, Herrup K. White Matter Degeneration and Aberrant Oligodendrocyte Differentiation During the Progress of Alzheimer's Disease. Society for Neuroscience 2015, Chicago, submitted 2015. (Abstract)

60.   Vidoni ED, Yeh H, Newell K, Alqahtani A, Burns NC, Morris JK, Burns JM, Billinger SA. Cerebral Amyloid Angiopathy is Associated with Earlier Dementia Onset. Cerebrovascular diseases, submitted 2015.

61.   Viswanathan A, Macklin EA, Betensky R, Hyman B, Smith EE, Blacker D. The Influence of Vascular Risk Factors and Stroke on Cognition in Late Life: Analysis of the NACC Cohort. Alzheimer Dis Assoc Disord, in press 2015, NIHMS648263.

62.   Wang LS, Naj AC, Graham RR, Crane PK, Kunkle BW, Cruchaga C, Murcia JD, Cannon-Albright L, Baldwin CT, Zetterberg H, Blennow K, Kukull WA, Faber KM, Schupf N, Norton MC, Tschanz JT, Munger RG, Corcoran CD, Rogaeva E, Lin CF, Dombroski BA, Cantwell LB, Partch A, Valladares O, Hakonarson H, St George-Hyslop P, Green RC, Goate AM, Foroud TM, Carney RM, Larson EB, Behrens TW, Kauwe JS, Haines JL, Farrer LA, Pericak-Vance MA, Mayeux R, Schellenberg GD, Albert MS, Albin RL, Apostolova LG, Arnold SE, Barber R, Barmada MM, Barnes LL, Beach TG, Becker JT, Beecham GW, Beekly D, Bennett DA, Bigio EH, Bird TD, Blacker D, Boeve BF, Bowen JD, Boxer A, Burke JR, Buxbaum JD, Cairns NJ, Cao C, Carlson CS, Carroll SL, Chui HC, Clark DG, Cribbs DH, Crocco EA, DeCarli C, DeKosky ST, Demirci FY, Dick M, Dickson DW, Duara R, Ertekin-Taner N, Fallon KB, Farlow MR, Ferris S, Frosch MP, Galasko DR, Ganguli M, Gearing M, Geschwind DH, Ghetti B, Gilbert JR, Glass JD, Graff-Radford NR, Growdon JH, Hamilton RL, Hamilton-Nelson KL, Harrell LE, Head E, Honig LS, Hulette CM, Hyman BT, Jarvik GP, Jicha GA, Jin LW, Jun G, Kamboh MI, Karydas A, Kaye JA, Kim R, Koo EH, Kowall NW, Kramer JH, Kramer P, LaFerla FM, Lah JJ, Leverenz JB, Levey AI, Li G, Lieberman AP, Lopez OL, Lunetta KL, Lyketsos CG, Mack WJ, Marson DC, Martin ER, Martiniuk F, Mash DC, Masliah E, McCormick WC, McCurry SM, McDavid AN, McKee AC, Mesulam MM, Miller BL, Miller CA, Miller JW, Montine TJ, Morris JC, Murrell JR, Olichney JM, Parisi JE, Perry W, Peskind E, Petersen RC, Pierce A, Poon WW, Potter H, Quinn JF, Raj A, Raskind M, Reiman EM, Reisberg B, Reitz C, Ringman JM, Roberson ED, Rosen HJ, Rosenberg RN, Sano M, Saykin AJ, Schneider JA, Schneider LS, Seeley WW, Smith AG, Sonnen JA, Spina S, Stern RA, Tanzi RE, Thornton-Wells TA, Trojanowski JQ, Troncoso JC, Tsuang DW, Van Deerlin VM, Van Eldik LJ, Vardarajan BN, Vinters HV, Vonsattel JP, Weintraub S, Welsh-Bohmer KA, Williamson J, Wishnek S, Woltjer RL, Wright CB, Younkin SG, Yu CE, Yu L. Rarity of the Alzheimer disease-protective APP A673T variant in the United States. JAMA Neurology, 72:209-216, 2015, PMC4324097.

63.   Wharton W, Goldstein FC, Zhao L, Steenland K, Levey AI, Hajjar I. Renin-Angiotensin-System Modulation may slow the Conversion from Mild Cognitive Impairment to Alzheimer's Disease. J Am Geriatr Soc, submitted 2015.

64.   Woon FL. Predicting Progression from Mild Cognitive Impairment to Dementia with CAIDE Dementia Risk Score. National Academy of Neuropsychology, submitted 2015. (Abstract)

65.   Wyman-Chick KA, Scott BJ. Development of Clinical Dementia Rating Scale Cutoff Scores for Patients with Parkinson's Disease. Movement disorders, in press 2015, NIHMS684277.

66.   Yu T, Chen B, Li P, Qin J. Pseudo-likelihood based inferences for semiparametric transformation model. Journal of the American Statistical Association, submitted 2015.

67.   Yu W, Kim J, Park T. Estimation of AUC through propensity-score-adjustment approach undernonignorable verication bias. Biometrics, submitted 2015.

68.   Zhang Y, Zhou XH, Meranus DH, Wang L, Kukull WA. Benzodiazepine use and cognitive decline in older adults with normal cognition. Alzheimer Dis Assoc Disord, in press 2015, PMC in process.

 
         2014
69.   Allen M, Kachadoorian M, Quicksall Z, Zou F, Chai HS, Younkin C, Crook JE, Pankratz VS, Carrasquillo MM, Krishnan S, Nguyen T, Ma L, Malphrus K, Lincoln S, Bisceglio G, Kolbert CP, Jen J, Mukherjee S, Kauwe JK, Crane PK, Haines JL, Mayeux R, Pericak-Vance MA, Farrer LA, Schellenberg GD, ADGC Collaborators, Parisi JE, Petersen RC, Graff-Radford NR, Dickson DW, Younkin SG, Ertekin-Taner N. Association of MAPT haplotypes with Alzheimer's disease risk and MAPT brain gene expression levels. Alz Rsch Therapy, 6:39, 2014, PMC4198935.

70.   Altmann A, Tian L, Henderson VW, Greicius MD. Sex modifies the APOE-related risk of developing Alzheimer's disease. Ann Neurol, 75:563-573, 2014, PMC4117990.

71.   Anor CJ, Hu B, Multani N, Tartaglia MC. Examining the Association between Neuropsychiatric Symptoms, Hypertension, Hypercholesterolemia, and Diabetes in Alzheimer's disease. Alzheimers and Dementia, 10:P364, 2014. (Abstract)

72.   Beach TG, Schneider JA, Sue LI, Serrano G, Dugger BN, Monsell SE, Kukull W. Theoretical impact of Florbetapir (18F) amyloid imaging on diagnosis of alzheimer dementia and detection of preclinical cortical amyloid. J Neuropath Exp Neurol, 73:948-953, 2014, PMC4169306.

73.   Beecham GW, Hamilton K, Naj AC, Martin ER, Huentelman M, Myers AJ, Corneveaux JJ, Hardy J, Vonsattel JP, Younkin SG, Bennett DA, De Jager PL, Larson EB, Crane PK, Kamboh MI, Kofler JK, Mash DC, Duque L, Gilbert JR, Gwirtsman H, Buxbaum JD, Kramer P, Dickson DW, Farrer LA, Frosch MP, Ghetti B, Haines JL, Hyman BT, Kukull WA, Mayeux RP, Pericak-Vance MA, Schneider JA, Trojanowski JQ, Reiman EM, Schellenberg GD, Montine TJ. Genome-Wide Association Meta-analysis of Neuropathologic Features of Alzheimer's Disease and Related Dementias. PLoS genetics, 10:e1004606, 2014, PMC4154667.

74.   Benitez BA, Jin SC, Guerreiro R, Graham R, Lord J, Harold D, Sims R, Lambert JC, Gibbs JR, Bras J, Sassi C, Harari O, Bertelsen S, Lupton MK, Powell J, Bellenguez C, Brown K, Medway C, Haddick PC, van der Brug MP, Bhangale T, Ortmann W, Behrens T, Mayeux R, Pericak-Vance MA, Farrer LA, Schellenberg GD, Haines JL, Turton J, Braae A, Barber I, Fagan AM, Holtzman DM, Morris JC, Williams J, Kauwe JS, Amouyel P, Morgan K, Singleton A, Hardy J, Goate AM, Cruchaga C, ADGC Collaborators. Missense variant in TREML2 protects against Alzheimer's disease. Neurobiol Aging, 35:1510 e1519-1526, 2014, PMC3961557.

75.   Benson G, de Felipe J, Xiaodong, Sano M. Performance of Spanish-speaking community-dwelling elders in the United States on the Uniform Data Set. Alzheimers and Dementia, 10:S338-343, 2014, PMC4092047.

76.   Berres M, Kukull WA, Miserez AR, Monsch AU, Monsell SE, Spiegel R. A Novel Study Paradigm for Long-term Prevention Trials in Alzheimer Disease: The Placebo Group Simulation Approach (PGSA). Application to MCI data from the NACC database.. J Prevention Alzheimers Dis, 1:99-109, 2014, PMC4268776.

77.   Besser L, Monsell S, Heller K, Litvan I, Kukull W. Mild Cognitive Impairment among Parkinson's Disease subjects in the Uniform Data Set. Alzheimers and Dementia, 10:P689-690, 2014. (Abstract)

78.   Besser LM, Gill DP, Hubbard RA, Monsell SE, Heller KB, Koepsell TD, Petrella RJ, Knopman DS, Kukull W. Differences in Rate of Clinical Progression of Three Dementia Types. revision 2014.

79.   Besser LM, Gill DP, Monsell SE, Brenowitz W, Meranus DH, Kukull W, Gustafson DR. Body Mass Index, Weight Change, and Clinical Progression in Mild Cognitive Impairment and Alzheimer Disease. Alzheimer Dis Assoc Diord, 28:36-43, 2014, PMC3945175.

80.   Brenowitz WD, Kukull WA, Beresford SA, Monsell SE, Williams EC. Social Relationships and Risk of Incident Mild Cognitive Impairment in US Alzheimer's Disease Centers. Alzheimer Dis Assoc Disord, 28:253-260, 2014, PMC4139444.

81.   Brenowitz WD, Monsell SE, Schmitt FA, Kukull WA, Nelson PT. Hippocampal sclerosis of aging is a key Alzheimer's disease mimic: clinical-pathologic correlations and comparisons with both alzheimer's disease and non-tauopathic frontotemporal lobar degeneration. J Alzheimers Dis, 39:691-702, 2014, PMC3946156.

82.   Chen B, Qin J. Test the reliability of doubly robust estimation with missing response data. Biometrics, 70:289-298, 2014, PMC4061274.

83.   Chen B, Qin J. Use of empirical likelihood to calibrate auxiliary information in partly linear monotone regression models. Stat Med, 33:1713-1722, 2014, PMC3981901.

84.   Chen W, Albert MA, Han DF, Lyketsos CG, Rosenberg PB. Neuropathological correlates of apathy in Alzheimer's Disease. Am J Geriatr Psychiatry, submitted 2014.

85.   Chung EJ, Babulal GM, Roe CM, Monsell SE, Cairns N, Morris JC. Clinical features of Alzheimer's disease with Lewy bodies. AD/PD 2015, submitted 2014. (Abstract)

86.   Clem M, Pandya S, Horton D, Hynan L, Lacritz L, Woon F. A-80Neuropsychological Prediction of Diagnostic Stability of Mild Cognitive Impairment. Arch Clin Neuropsychol, 29:533, 2014. (Abstract)

87.   Cohen ML, Kim C, Haldiman T, ElHag M, Mehndiratta P, Pichet T, Lissemore F, Cohen Y, Chen W, Blevins J, Surewicz K, Surewicz W, Sajatovic M, Tatsuoka C, Zhang S, Lerner A, Safar JG. Distinct Structures of β-Amyloid in Rapidly Progressive Alzheimer Disease. Ann Neurol, submitted 2014.

88.   Crary JF, Trojanowski JQ, Schneider JA, Abisambra JF, Erin L. Abner P, Alafuzoff I, Arnold SE, Attems J, Beach TG, Bigio EH, Cairns NJ, Dickson DW, Gearing M, Grinberg LT, Hof PR, Hyman BT, Jicha GA, Jellinger K, Kovacs GG, Knopman DS, Kofler J, Kukull WA, Mackenzie IR, Masliah E, McKee AC, Montine TJ, Murray ME, Neltner JH, Santa-Maria I, Seeley WW, Serrano-Pozo A, Shelanski ML, Stein TD, Takao M, Thal DR, Toledo JB, Troncoso JC, Vonsattel JP, 3rd CLW, Wisniewski T, Woltjer RL, Yamada M, Nelson PT. Primary age-related tauopathy (PART): a common pathology associated with human aging. Acta Neuropathol, 128:755-766, 2014, PMC4257842.

89.   Cummings JL, Ringman J, Vinters H. Neuropathologic correlates of trial-related instruments for Alzheimer's disease. Am J Neurodegen Disease, 3:45-49, 2014, PMC3986610.

90.   Deutsch M, Mendez M, Teng E. Medical risk factors for frontotemporal degeneration: Analysis of the NACC Uniform Dataset. Neurology, 82:S58.002, 2014. (Abstract)

91.   Deutsch MB, Mendez M, Teng E. The Association Between Frontotemporal Degeneration and Traumatic Brain Injury. Am J Neurodegener Dis, 3:189, 2014. (Abstract)

92.   Escott-Price V, Bellenguez C, Wang LS, Choi SH, Harold D, Jones L, Holmans P, Gerrish A, Vedernikov A, Richards A, DeStefano AL, Lambert JC, Ibrahim-Verbaas CA, Naj AC, Sims R, Jun G, Bis JC, Beecham GW, Grenier-Boley B, Russo G, Thornton-Wells TA, Denning N, Smith AV, Chouraki V, Thomas C, Ikram MA, Zelenika D, Vardarajan BN, Kamatani Y, Lin CF, Schmidt H, Kunkle B, Dunstan ML, Vronskaya M, Johnson AD, Ruiz A, Bihoreau MT, Reitz C, Pasquier F, Hollingworth P, Hanon O, Fitzpatrick AL, Buxbaum JD, Campion D, Crane PK, Baldwin C, Becker T, Gudnason V, Cruchaga C, Craig D, Amin N, Berr C, Lopez OL, De Jager PL, Deramecourt V, Johnston JA, Evans D, Lovestone S, Letenneur L, Hernandez I, Rubinsztein DC, Eiriksdottir G, Sleegers K, Goate AM, Fievet N, Huentelman MJ, Gill M, Brown K, Kamboh MI, Keller L, Barberger-Gateau P, McGuinness B, Larson EB, Myers AJ, Dufouil C, Todd S, Wallon D, Love S, Rogaeva E, Gallacher J, George-Hyslop PS, Clarimon J, Lleo A, Bayer A, Tsuang DW, Yu L, Tsolaki M, Bossu P, Spalletta G, Proitsi P, Collinge J, Sorbi S, Garcia FS, Fox NC, Hardy J, Naranjo MC, Bosco P, Clarke R, Brayne C, Galimberti D, Scarpini E, Bonuccelli U, Mancuso M, Siciliano G, Moebus S, Mecocci P, Zompo MD, Maier W, Hampel H, Pilotto A, Frank-Garcia A, Panza F, Solfrizzi V, Caffarra P, Nacmias B, Perry W, Mayhaus M, Lannfelt L, Hakonarson H, Pichler S, Carrasquillo MM, Ingelsson M, Beekly D, Alvarez V, Zou F, Valladares O, Younkin SG, Coto E, Hamilton-Nelson KL, Gu W, Razquin C, Pastor P, Mateo I, Owen MJ, Faber KM, Jonsson PV, Combarros O, O'Donovan MC, Cantwell LB, Soininen H, Blacker D, Mead S, Mosley TH, Jr., Bennett DA, Harris TB, Fratiglioni L, Holmes C, de Bruijn RF, Passmore P, Montine TJ, Bettens K, Rotter JI, Brice A, Morgan K, Foroud TM, Kukull WA, Hannequin D, Powell JF, Nalls MA, Ritchie K, Lunetta KL, Kauwe JS, Boerwinkle E, Riemenschneider M, Boada M, Hiltunen M, Martin ER, Schmidt R, Rujescu D, Dartigues JF, Mayeux R, Tzourio C, Hofman A, Nothen MM, Graff C, Psaty BM, Haines JL, Lathrop M, Pericak-Vance MA, Launer LJ, Van Broeckhoven C, Farrer LA, van Duijn CM, Ramirez A, Seshadri S, Schellenberg GD, Amouyel P, Williams J. Gene-wide analysis detects two new susceptibility genes for Alzheimer's disease. PLoS ONE, 9:e94661, 2014, PMC4055488.

93.   Fowler NR, Johnson KG, Lie J, Moore CG, Saba S, Lopez O, Barnato AE. Use of cardiac implantable electronic devices in older adults with cognitive impairment. JAMA Internal Med, 174:1514-1516, 2014, PMC4271315.

94.   Galkina E, Grinstein G. Comparison of interpolation methods for estimating spatially aggregated pollution exposure. 8th International Conference on Information Visualization, Paris,, 2014. (Abstract)

95.   Galkina E, Grinstein G. Regional differences in diagnostic conversion to dementia. 8th International Conference on Information Visualization, Paris,, 2014. (Abstract)

96.   Gaugler JE, Hovater M, Roth DL, Johnston JA, Kane RL, Sarsour K. Depressive, functional status, and neuropsychiatric symptom trajectories before an Alzheimer's disease diagnosis. Aging Mental Health, 18:110-116, 2014, PMC3855584.

97.   Gavett BE, John SE, Gurnani AS, Saurman J, Bussell C. The role of Alzheimer's and cerebrovascular pathology in mediating the effects of age, race, and apolipoprotein E genotype on dementia severity in pathologically confirmed Alzheimer's disease. J Alzheimers Dis, submitted 2014.

98.   Gifford KA, Liu D, Jefferson AL. Source of cognitive complaint and neuropathology in mild cognitive impairment. Alzheimer's & Dementia, (10)4 Supplement:P422-P423, 2014. (Abstract)

99.   Green C. Modeling Disease Progression in Alzheimer's Dementia to Inform Analysis. ISPOR 17th Annual European Congress, submitted 2014. (Abstract)

100.   Grill JD, Monsell S. Choosing Alzheimer's disease prevention clinical trial populations. Neurobiol Aging, 35:466-471, 2014, PMC3864603.

101.   Grill JD, Vinters HV, Monsell SE. Does Alzheimer's disease pathologic change underlie subjective cognitive complaints?. Alzheimers Disease Associated Disorders, submitted 2014.

102.   Gross A, Sherva R, Mukherjee S, Newhouse S, Kauwe J, Munsie L, Waterston L, Bennett D, Jones R, Green R, Crane P, ADNI Collaborators, GENAROAD Collaborators, ADGC Collaborators. Calibrating longitudinal cognition in Alzheimer's disease across diverse test batteries and datasets. Neuroepidemiology, 43:194-205, 2014, PMC4297570.

103.   Gross AL, Mukherjee S, Sherva R, Newhouse S, Waterston LB, Jones RN, Green RC, Crane PK, ADNI Collaborators, GENAROAD Collaborators. Calibrating Longitudinal Cognitive Performance Across Diverse Neuropsychological Batteries and Datasets. Alzheimers and Dementia, 10:P746, 2014. (Abstract)

104.   Gu Y, Scarmeas N, Cosentino S, Brandt J, Albert M, Blacker D, Dubois B, Mayeux R, Stern Y. Change in Body Mass Index Before and After Alzheimer's Disease Onset. Curr Alzheimer Res, 11:349-356, 2014, PMC4026350.

105.   Haj-Hassan S, Hohman T, Liu D, Skinner J, Lu Z, Sparling J, Gifford K, Sumner E, Bell S, Jefferson A. A-28Vascular Risk and Cognitive Decline in Older Adults with and without Mild Cognitive Impairment (MCI). Arch Clin Neuropsychol, 29:513, 2014. (Abstract)

106.   Hao Y, Hameed S, Ting S. Clinicopathological Investigation of Psychosis in Alzheimer's disease using an Advanced Decision Tree Algorithm. SingHealth Duke-NUS Scientific Congress, accepted 2014. (Abstract)

107.   Heller K, DeCarli C, Beekly D, Besser L, Bollenbeck M, Wu J, Carmichael O, Phelps C, Kukull W. The National Alzheimer's Coordinating Center MRI Database. Alzheimers and Dementia, 10:P833-834, 2014. (Abstract)

108.   Herberger V, Hodges EK, Giordani B, Zhu J, Dodge HH. Type 2 Diabetes Mellitus: Longitudinal Impact on Cognition in Persons with Normal Cognition, MCI, and Dementia. Alzheimers and Dementia, 10:P848, 2014. (Abstract)

109.   Hutchinson K, Dilks L, DuVall T. A-73Risk Factors for Apathy in Alzheimer's Disease. Arch Clin Neuropsychol, 29:530, 2014. (Abstract)

110.   Jefferson AL. Hemodynamic factors underlying the pathogenesis and clinical expression. J Int Neuropsychol Soc, 20:S36, 2014. (Abstract)

111.   Jones L, Lambert JC, Wang LS, Schellenberg GD, Seshadri S, Amouyel P, Williams J, Holmans PA, ADGC Collaborators. Convergent genetic and expression data implicate immunity in Alzheimer's disease. Alzheimers and Dementia, in press 2014.

112.   Joshi A, Teng E, Tassniyom K, Mendez MF. Hippocampal and mesial temporal sclerosis in early-onset frontotemporal lobar degeneration versus Alzheimer's disease. Am J Alzheimers Dis Other Demen, 29:45-49, 2014, PMC3947801.

113.   Kalapatapu RK, Delucchi KL, Wang S, Harbison J, Nelson EE, Kramer JH. Substance Use History in Behavioral-Variant Frontotemporal Dementia versus Primary Progressive Aphasia: A Baseline Analysis of a National Dataset. J Addictive Disease, submitted 2014.

114.   Kielb S, Rogalski E, Weintraub S. Subjective Cognitive Complaints and Early Cognitive Features in Preclinical Alzheimer's Disease. 43rd Annual International Neuropsychological Society Meeting, submitted 2014. (Abstract)

115.   Knopman D, Monsell S, Kukull W. US Alzheimer Centers' NACC FTLD Module: Initial Experience. International FTD Conference, Vancouver BC, Oct 24, 2014. (Abstract)

116.   Kolman S, Galkina E, Dufilie AS, Luo YF, Gupta V, Grinstein G. Linked visual analysis of structured datasets and document collections. Visualization and Data Analysis 2014 Proceedings of SPIE, 2014. (Abstract)

117.   Lane EM, Liu D, Xu M, Bell SP, Niswender KD, Jefferson AL. The Impact of Diabetes Medications on Alzheimer's Disease and Vascular Neuropathology. J Int Neuropsychol Soc, 20:S160, 2014. (Abstract)

118.   Leger GC, Banks SJ. Neuropsychiatric Symptom Profile Differs Based on Pathology in Patients with Clinically Diagnosed Behavioral Variant Frontotemporal Dementia.. Dement Geriatr Cogn Disord, 37:104-112, 2014, PMC4041327.

119.   Lin A, Zhang JY, Jimenez E, Paholpak P, Teng E, Mendez MF. PREVALENCE OF TRAUMATIC BRAIN INJURY IN EARLY VERSUS LATE-ONSET ALZHEIMER'S DISEASE. AAN 2015, submitted 2014. (Abstract)

120.   Liu D, Skinner J, Gifford K, Jefferson AL. Biracial differences in the relation between vascular health and neuropathological markers of cerebrovascular disease and Alzheimer's disease. Alzheimers and Dementia, 10:P843, 2014. (Abstract)

121.   Liu D, Zhou XH. Estimation of ROC curve with multiple types of missing gold standard. ICSA 2013 Symposium Book, submitted 2014.

122.   LoBue C, Lacritz L, Hart J, Jr., Kyle W, Cullum M. A-26Self-Reported Head Injury and Earlier Age of Diagnosis of Mild Cognitive Impairment. Arch Clin Neuropsychol, 29:512, 2014. (Abstract)

123.   Logue MW, Schu M, Vardarajan BN, Farrell J, Bennett DA, Buxbaum JD, Byrd GS, Ertekin-Taner N, Evans D, Foroud T, Goate A, Graff-Radford NR, Kamboh MI, Kukull WA, Manly JJ.. Two rare AKAP9 variants are associated with Alzheimer's disease in African Americans. Alzheimers Dement, 10:609-618, 2014, PMC4253055.

124.   Maddox RA, Blase JL, Mercaldo ND, Gambetti P, Harvey AR, Schonberger LB, Kukull WA, Belay ED. Clinically Unsuspected Prion Disease among Patients with Dementia Diagnoses. Neuroepidemiology, submitted 2014.

125.   Millikin C, Stoesz BM, Ismail Z, Fischer CE, Schweizer T. Factors Associated with Development and Stability of Delusions in Probable Alzheimer's Disease. Am J Geriatric Psychiatry, 22:S118-S119, 2014. (Abstract)

126.   Moga DC, Abner E, Jicha G. Bladder Antimuscarinics and Cognitive Decline in Elderly Patients Enrolled in the National Alzheimer's Coordinating Center Cohort. Pharmacoepidemiol Drug Saf, 23(S1):173-174, 2014. (Abstract)

127.   Moga DC, Abner E, Jicha G. Bladder Antimuscarinics Use by Older Women Enrolled in the National Alzheimer's Coordinating Center cohort. SER, 2014. (Abstract)

128.   Moga DC, Abner E, Jicha G. URINARY INCONTINENCE TREATMENT IN OLDER WOMEN ENROLLED IN THE NATIONAL ALZHEIMER'S COORDINATING CENTER COHORT. Path to Prevention of LUTS Workshop, Bethesda MD, submitted 2014. (Abstract)

129.   Monsell SE, Besser LM, Heller KB, Checkoway H, Litvan I, Kukull WA. Clinical and pathologic presentation in Parkinson's disease by apolipoprotein e4 allele status. Parkinsonism & related disorders, 20:503-507, 2014, PMC4028373.

130.   Monsell SE, Mock C, Hassenstab J, Roe CM, Cairns NJ, Morris JC, Kukull WK. Neuropsychological changes in asymptomatic persons with Alzheimer's disease neuropathology. Neurology, 83:434-440, 2014, PMC4132573.

131.   Monsell SE, Caselli RJ, Kukull WA, Beach TG, Montine TJ, Reiman EM. APOE4 non-carriers with the clinical diagnosis of Alzheimer's dementia and minimal amyloid histopathology. Alzheimers and Dementia, 10:P423, 2014. (Abstract)

132.   Naj AC, Jun G, Reitz C, Kunkle BW, Perry W, Park YS, Beecham GW, Rajbhandary RA, Hamilton-Nelson KL, Wang LS, Kauwe JS, Huentelman MJ, Myers AJ, Bird TD, Boeve BF, Baldwin CT, Jarvik GP, Crane PK, Rogaeva E, Barmada MM, Demirci FY, Cruchaga C, Kramer PL, Ertekin-Taner N, Hardy J, Graff-Radford NR, Green RC, Larson EB, St George-Hyslop PH, Buxbaum JD, Evans DA, Schneider JA, Lunetta KL, Kamboh MI, Saykin AJ, Reiman EM, De Jager PL, Bennett DA, Morris JC, Montine TJ, Goate AM, Blacker D, Tsuang DW, Hakonarson H, Kukull WA, Foroud TM, Martin ER, Haines JL, Mayeux RP, Farrer LA, Schellenberg GD, Pericak-Vance MA, Albert MS, Albin RL, Apostolova LG, Arnold SE, Barber R, Barnes LL, Beach TG, Becker JT, Beekly D, Bigio EH, Bowen JD, Boxer A, Burke JR, Cairns NJ, Cantwell LB, Cao C, Carlson CS, Carney RM, Carrasquillo MM, Carroll SL, Chui HC, Clark DG, Corneveaux J, Cribbs DH, Crocco EA, DeCarli C, DeKosky ST, Dick M, Dickson DW, Duara R, Faber KM, Fallon KB, Farlow MR, Ferris S, Frosch MP, Galasko DR, Ganguli M, Gearing M, Geschwind DH, Ghetti B, Gilbert JR, Glass JD, Growdon JH, Hamilton RL, Harrell LE, Head E, Honig LS, Hulette CM, Hyman BT, Jicha GA, Jin LW, Karydas A, Kaye JA, Kim R, Koo EH, Kowall NW, Kramer JH, LaFerla FM, Lah JJ, Leverenz JB, Levey AI, Li G, Lieberman AP, Lin CF, Lopez OL, Lyketsos CG, Mack WJ, Martiniuk F, Mash DC, Masliah E, McCormick WC, McCurry SM, McDavid AN, McKee AC, Mesulam M, Miller BL, Miller CA, Miller JW, Murrell JR, Olichney JM, Pankratz VS, Parisi JE, Paulson HL, Peskind E, Petersen RC, Pierce A, Poon WW, Potter H, Quinn JF, Raj A, Raskind M, Reisberg B, Ringman JM, Roberson ED, Rosen HJ, Rosenberg RN, Sano M, Schneider LS, Seeley WW, Smith AG, Sonnen JA, Spina S, Stern RA, Tanzi RE, Thornton-Wells TA, Trojanowski JQ, Troncoso JC, Valladares O, Van Deerlin VM, Van Eldik LJ, Vardarajan BN, Vinters HV, Vonsattel JP, Weintraub S, Welsh-Bohmer KA, Williamson J, Wishnek S, Woltjer RL, Wright CB, Younkin SG, Yu CE, Yu L. Effects of multiple genetic loci on age at onset in late-onset Alzheimer disease: a genome-wide association study. JAMA Neurology, 71:1394-1404, 2014, PMC4314944.

133.   Nelson PT, Abner E, Kukull WA, Monsell SE, Ighodaro E, Fardo D. Association between hippocampal sclerosis of aging (HS-Aging) pathology and sulfonylurea drug exposure. AANP 2014, submitted 2014. (Abstract)

134.   Nelson PT, Estus S, Abner EL, Parikh I, Malik M, Neltner JH, Ighodaro E, Schellenberg GA, Wang WX, Wilfred BR, Kukull WA, Nandakumar K, Farman ML, Kofler JK, Poon WW, Corrada M, Kawas CH, Jicha GA, Hubbard RA, Bennett DA, Schneider JA, Sonnen JA, Crane PK, Wang LS, Cantwell L, Valladares O, Van Eldik L, Larson EB, Horbinski C, Green RC, Gearing M, Kramer PL, Woltjer RL, Wang X, Kamboh IM, Montine TJ, Partch AB, Oliver K, Monsell SE, ADGC C, Fardo DW. ABCC9 gene polymorphism is associated with hippocampal sclerosis of aging pathology. Acta Neuropathol, 127:825-843, 2014, PMC4113197.

135.   Neltner JH, Abner EL, Baker S, Schmitt FA, Kryscio RJ, Jicha GA, Smith CD, Hammack E, Kukull WA, Brenowitz WD, Van Eldik LJ, Nelson PT. Arteriolosclerosis that affects multiple brain regions is linked to hippocampal sclerosis of ageing. Brain, 137:255-267, 2014, PMC3891448.

136.   Ossenkoppele R, Jansen WJ, Rabinovici GD, Knol DL, van der Flier WM, van Berckel BNM, Scheltens P, Visser PJ. Prevalence of Amyloid in Demented Subjects. JAMA, submitted 2014.

137.   Pandya SY, Clem MA, Horton DK, Lacritz LH, Cullum CM, Woon FL. Medication use as a predictor of reversion from mild cognitive impairment to normal cognition. 12th annual meeting of the American Academy of Clinical Neuropsychology, New York, NY, 2014. (Abstract)

138.   Pandya SY, Clem MA, Horton DK, Lacritz LH, Woon FL. Psychiatric symptoms in individuals reverting to normal cognition from mild cognitive impairment. 34th annual meeting of the National Academy of Neuropsychology, Puerto Rico, PR, 2014. (Abstract)

139.   Pillai JA, Bonner-Jackson A, Walker E, Mourany L, Cummings JL. Higher Working Memory Predicts Slower Functional Decline in Autopsy-Confirmed Alzheimer's Disease. Dement Geriatr Cogn Disord, 38:224-233, 2014, PMC4140977.

140.   Ringman JM, Sachs MC, Zhou Y, Monsell SE, Saver JL, Vinters HV. Clinical predictors of severe cerebral amyloid angiopathy and influence of APOE genotype in persons with pathologically-verified Alzheimer's disease. JAMA Neurology, 71:878-883, 2014, PMC4101018.

141.   Ronquillo JG, Baer MR, Lester WT. A big data approach to identifying and analyzing sex-specific patterns and differences in dementia and Alzheimer's disease. JAMA Neurology, submitted 2014.

142.   Sadak TI, Katon J, Beck C, Cochrane BB, Borson S. Key neuropsychiatric symptoms in common dementias: prevalence and implications for caregivers, clinicians, and health systems. Res Gerongol Nurs, 7:44-52, 2014, PMC3909707.

143.   Sayegh P, Knight BG. Functional assessment and neuropsychiatric inventory questionnaires: measurement invariance across hispanics and non-Hispanic whites. Gerontologist, 54:375-386, 2014, PMC4031565.

144.   Sayegh P. The Role of Neuropsychological Language Tests in Clinician-rated Dementia Severity across Hispanics and Non-Hispanic Whites. International Neuropsychological Society 42nd Annual Meeting, Seattle, WA, 2014. (Abstract)

145.   Serrano-Pozo A, Qian J, Monsell SE, Blacker D, Gomez-Isla T, Betensky RA, Growdon JH, Johnson KA, Frosch MP, Sperling RA, Hyman BT.. Mild to moderate Alzheimer dementia with insufficient neuropathological changes. Ann Neurol, 75:597-601, 2014, PMC4016558.

146.   Sherva R, Tripodis Y, Bennett DA, Chibnik LB, Crane PK, de Jager PL, Farrer LA, Saykin AJ, Shulman JM, Naj A, Green RC, ADGC Collaborators. Genome-wide association study of the rate of cognitive decline in Alzheimer's disease. Alzheimers and Dementia, 10:45-52, 2014, PMC3760995.

147.   Skinner J, Liu D, Xu M, Gifford K, Jefferson A. Stroke Risk Profile as a Predictor of Cognition in Minority Elders. J Int Neuropsychol Soc, 20:S90, 2014. (Abstract)

148.   Snowden MB, Atkins DC, Steinman LE, Bell JF, Bryant LL, Copeland C, Fitzpatrick AL. Longitudinal Association of Dementia and Depression. Am J Geriatr Psychiatry, in press 2014, PMC4369182.

149.   Spiegel R, Berres M, Monsch A, Miserez A, Kukull WA. Validating the Placebo Group Simulation Approach (PGSA), an Alternative Study Design for Preventive Trials in Prodromal AD Patients. Alzheimers and Dementia, 10:P859, 2014. (Abstract)

150.   Steed D, Miller SA. Teasing Apart Concurrent and Predictive Influences on Dementia and Neuropsychiatric Symptoms. J Int Neuropsychol Soc, 20:S83, 2014. (Abstract)

151.   Steed D. Differential Predictive Influence on the Development of Dementia: Depression and Neuropsychiatric Symptoms. 43rd Annual International Neuropsychological Society Meeting, submitted 2014. (Abstract)

152.   Steed D. Predicting development of dementia: A parallel process latent growth curve analysis. 43rd Annual International Neuropsychological Society Meeting, submitted 2014. (Abstract)

153.   Tartaglia MC, Hu B, Mehta K, Neuhaus J, Yaffe K, Miller BL, Boxer A. Demographic and neuropsychiatric factors associated with off-label medication use in frontotemporal dementia and Alzheimer's disease. Alzheimer Dis Assoc Disord, 28:182-189, 2014, PMC3938980.

154.   Teng, YL. The Alzheimer's Disease Centers Uniform Data Set (UDS): Using various algorithms to predict Dementia types with MMSE and CDR NACC is funded by the National Institute on Aging (UO1 AG016976). Alzheimers and Dementia, 10:P676, 2014. (Abstract)

155.   Ting SKS, Hao Y, Tan EK, Hameed S. Clinical and pathological characteristics of Vitamin B12 deficiency in Alzheimer's Disease. Neurology, submitted 2014.

156.   Ting SKS, Hao Y, Tan EK, Hameed S. Clinicopathological correlation of psychosis and brain vascular changes in Alzheimer's disease. Alzheimers Disease Associated Disorders, submitted 2014.

157.   Torralva T, Sposato L, Roca M, Gleichgerrcht E, Riccio PM, Manes F, Hachinski V. The Role of Cerebrovascular Disease in Behavioral Variant Frontotemporal Dementia. ICFTD 2014, submitted 2014. (Abstract)

158.   Tosto G, Monsell SE, Hawes S, Mayeux R. CLUSTER ANALYSIS OF EXTRAPYRAMIDAL SIGNS IN ALZHEIMER'S DISEASE. Neurology, submitted 2014.

159.   Tosto G, Monsell SE, Kukull WS, Mayeux R. Latent Analysis of Extrapyramidal Signs In Alzheimer Disease Identifies Distinct Disease Expressions. Alzheimers and Dementia, 10:P819, 2014. (Abstract)

160.   Weintraub S. Neuropsychological Profiles of Dementia: Neuroanatomical Networks Disorders. Seminar, McGill Center For Studies in Aging, December 12, 2014, Montreal, Quebec, submitted 2014. (Abstract)

161.   Woodruff B, Hentz JG, Dueck AC, Locke DE, Stonnington CM, Wojtulewicz LB, Geda YE, Caselli RJ. Absence of a ”widowhood effect“ on incidence of dementia in cognitively normal research subjects. Alzheimers and Dementia, 10:P617-618, 2014. (Abstract)

162.   Woodruff B, Hentz JG, Dueck AC, Locke DE, Stonnington CM, Wojtulewicz LB, Geda YE, Caselli RJ. Paradoxical impact of widowhood on incidence of dementia in subjects with Mild Cognitive Impairment. Alzheimers and Dementia, 10:P617, 2014. (Abstract)

163.   Woon FL. Cognitive Predictors of Reversion to Normal Cognition from Mild Cognitive Impairment. Am Academy Clin N'psych 2014, accepted 2014. (Abstract)

164.   Woon M. Neuropsychological prediction of diagnostic stability of mild cognitive impairment. National Academy of Neuropsychology, submitted 2014. (Abstract)

165.   Zhao M, Chan RHM, Chow TWS, Tang P. Compact Graph based Semi-Supervised Learning for Medical Diagnosis in Alzheimer's Disease. IEEE Signal Processing Letters, in press 2014, NIHMS629797.

 
         2013
166.   Ascher-Svanum H, Gaugler J, Roth D, Fafowora T, Siderowf A, Beach T. Characteristics of Patients Misdiagnosed with Alzheimer's Disease and Their Medication Use: An Analysis of the NACC-UDS Database. Alzheimers and Dementia, 9:P734, 2013. (Abstract)

167.   Ayutyanont N, Langbaum JBS, Hendrix SB, Fleisher AS, Caselli R, Monsell SE, Chen K, Kukull WA, Bennett D, Tariot PN, Reiman EM. Validation of the Alzheimer's Prevention Initiative Composite Cognitive Test Score. Alzheimers and Dementia, 9:P320, 2013. (Abstract)

168.   Besser LM, Gill DP, Monsell SE, Brenowitz W, Meranus D, Gustafson D, Kukull W. Body Weight Change and Clinical Progression in Mild Cognitive Impairment and Alzheimer's Disease. Neurodegener Dis, 11(S1), 2013. (Abstract)

169.   Besser LM, Hawes SE, Bristow KE, Monsell SE, Kukull WA. Pulse Pressure and Atherosclerosis, Arteriolosclerosis, and Cortical Microinfarcts in Individuals with Clinical Alzheimer's Disease.. Alzheimers and Dementia, 9:P441, 2013. (Abstract)

170.   Brenowitz WD, Monsell SE, Kukull WA, Nelson PT. Hippocampal sclerosis of aging, a key potential AD confounder: the NACC experience. Alzheimers and Dementia, 9:P542, 2013. (Abstract)

171.   Brenowitz WD, Nelson PT, Besser LM, Bristow KE, Kukull WA. Cerebral Amyloid Angiopathy and its Co-occurrence with Alzheimer's Disease in the National Alzheimer's Coordinating Center Neuropathology Data Set. Alzheimers and Dementia, 9:P433, 2013. (Abstract)

172.   Bristow KE, Besser LM, Monsell SE, Brenowitz W, Hawes SE, Kukull WA. Consensus Diagnosis and Predictors of Diagnostic Accuracy in the National Alzheimer's Disease Centers. Alzheimers and Dementia, 9:P321, 2013. (Abstract)

173.   Bruns M, Bristow K, Monsell SE, Aakre J, Kukull W, Pankratz V, Knopman D, Graff-Radford N, Miller B, Laden F, Dickinson S, Mesulam M, Boeve B. Similar maximal educational attainment in people with dementia: Association with pathologically diagnosed frontotemporal lobar degeneration, Alzheimer's disease and Lewy body disease?. Alzheimers and Dementia, 9:P631, 2013. (Abstract)

174.   Bruns M, Pankratz VS, Wicklund M, Kukull W, Knopman D, Graff-Radford N, Miller B, Laden F, Mesulam MM, Boeve B. Educational Attainment in Patients with Frontotemporal Dementia and Primary Progressive Aphasia Compared to Other Dementia Syndromes. Neurology, 80:P03.089, 2013. (Abstract)

175.   Burnham R, Xiong C, McIntosh L. DYNAMIC AND INTERACTIVE VISUALIZATION: Interpreting NACC Uniform Data while Encompassing Missing Assessments. HEALTHINF 2014, 7th international conference on health informatics, submitted 2013.

176.   Chen B, Zhou A. A Correlated Random Effects Model for Non-homogeneous Markov Process with Nonignorable Missingness. J Multivariate Analysis, 117:41287, 2013, PMC3697104.

177.   Chen B, Zhou A. Generalized Partially Linear Models for Incomplete Longitudinal Data In the Presence of Population-Level Information. Biometrics, 69:386-395, 2013, PMC3715115.

178.   Cheng Y, Trzepacz PT, Chang C, Hake AM, Siemers ER. Seizure and associated factors in patients with different types of dementia. Pharmacoepidemiol Drug Saf, 22(S1):266, 2013. (Abstract)

179.   Cocroft S. Alzheimer's Disease and African Americans. North Central Sociological Association's annual meeting, 2013. (Abstract)

180.   Cosentino S, Schupf N, Christensen K, Anderson S, Newman A, Mayeux R. Reduced Prevalence of Cognitive Impairment in Families With Exceptional Longevity. JAMA Neurology, 70:867-874, 2013, PMC4151346.

181.   Cruchaga C, Kauwe JS, Harari O, Jin SC, Cai Y, Karch CM, Benitez BA, Jeng AT, Skorupa T, Carrell D, Bertelsen S, Bailey M, McKean D, Shulman JM, De Jager PL, Chibnik L, Bennett DA, Arnold SE, Harold D, Sims R, Gerrish A, Williams J, Van Deerlin VM, Lee VM, Shaw LM, Trojanowski JQ, Haines JL, Mayeux R, Pericak-Vance MA, Farrer LA, Schellenberg GD, Peskind ER, Galasko D, Fagan AM, Holtzman DM, Morris JC, ADGC Collaborators, Goate AM. GWAS of cerebrospinal fluid tau levels identifies risk variants for Alzheimer's disease. Neuron, 78:256-268, 2013, PMC3664945.

182.   Dams-O'Connor K, Spielman L, Hammond FM, Sayed N, Culver C, Diaz-Arrastia R. An exploration of clinical dementia phenotypes among individuals with and without traumatic brain injury. Neurorehabilitation, 32:199-209, 2013, PMC3767178.

183.   De Felipe J, Benson G, Luo X, Sewell M, Sano M. Performance of Spanish Speaking Community dwelling elders in the US on the Uniform Data Set (UDS). Alzheimers and Dementia, 9:P621-623, 2013. (Abstract)

184.   Farrer LA. SORL1 is genetically associated with late-onset Alzheimer's disease in Japanese, Koreans and Caucasians. PLoS ONE, submitted 2013.

185.   Fowler NR, Sarles CE, Li J, Barnato AE. Prevalence and incidence of cardiac devices in a national Alzheimer's Disease Centers sample. J Am Geriatr Soc, 61:S106-107, 2013. (Abstract)

186.   Fowler NR. Decision quality and the use of cardiac rhythm regulating devices in adults with cognitive impairment. Alzheimers and Dementia, 9:P634, 2013. (Abstract)

187.   Galkina E, Purushe S, Grinstein GG.. Feasibility of pattern discovery in modeling cognitive decline in Alzheimer's disease using the Weave platform. VizBi Conference Cambridge MA, 2013. (Abstract)

188.   Gaugler JE, Ascher-Svanum H, Roth DL, Fafowora T, Siderowf A, Beach TG. Characteristics of patients misdiagnosed with alzheimer's disease and their medication use: an analysis of the NACC-UDS database. BMC Geriatrics, 13:137, 2013, PMC3878261.

189.   Gill DP, Hubbard RA, Koepsell TD, Borrie M, Petrella RJ, Knopman D, Kukull WA. Differences in rate of functional decline across three dementia types. Alzheimers and Dementia, 9:S63-71, 2013, PMC3766452.

190.   Giraldo M, Lopera F, Siniard AL, Corneveaux JJ, Schrauwen I, Carvajal J, Munoz C, Ramirez-Restrepo M, Gaiteri C, Myers AJ, Caselli RJ, Kosik KS, Reiman EM, Huentelman MJ. Variants in triggering receptor expressed on myeloid cells 2 are associated with both behavioral variant frontotemporal lobar degeneration and Alzheimer's disease. Neurobiol Aging, 34:2077 e11-8, 2013, PMC3830921.

191.   Goldstein FC, Levey AI, Steenland NK. High blood pressure and cognitive decline in mild cognitive impairment. J Am Geriatr Soc, 61:67-73, 2013, PMC3699694.

192.   Grill JD, Monsell S. Choosing Alzheimer's disease prevention trial populations. J Nutr Health Aging, 17:815-816, 2013. (Abstract)

193.   Gross A, Sherva R, Mukherjee S, Newhouse S, Waterston L, Zavitz K, Bennett D, Jones R, Crane P, Green R, ADNI, GENAROAD. Calibration of a new approach for estimating general cognitive performance for GWAS of cognitive decline in Alzheimer's disease. Alzheimers and Dementia, 9:P697-698, 2013. (Abstract)

194.   Gross AL, Sherva R, Mukherjee SR, Newhouse S, Kauwe J, Saykin AJ, Bennett DA, Chibnik LB, Kraft P, Crane PK, Green RC. Genome-Wide Association Study of Rate of Cognitive Decline in Six Cohorts with Patients with Alzheimer's Disease. 66th GSA Annual Scientific Meeting, New Orleans, LA, 2013. (Abstract)

195.   Gross AL, Sherva R, Mukherjee SR, Newhouse S, Waterston LB, Mungas DM, Green RC, Jones RN, Crane PK. Novel Approach for Calibrating Longitudinal Cognitive Performance in Older Adults. 66th GSA Annual Scientific Meeting, New Orleans, LA, 2013. (Abstract)

196.   Gu Y, Scarmeas N, Cosentino S, Brandt J, Albert M, Blacker D, Dubois B, Mayeux R, Stern Y. Body Mass Change in Alzheimer's Disease. Alzheimers and Dementia, 9:P206-207, 2013. (Abstract)

197.   Hart KR, Hanfelt JJ. Robust Latent Class Analysis for Longitudinal Data. Joint Statistical Meeting (JSM) Montreal, Canada, 2013. (Abstract)

198.   Hayden KM, Kuchibhatla M, Plassman BL, Germain CM, Romero HR, Welsh-Bohmer KA. The Use of Reliable Change Indices to Complement Norms in the Early Identification of Cognitive Decline. Alzheimers and Dementia, 9:P535-536, 2013. (Abstract)

199.   Holton P, Ryten M, Nalls M, Trabzuni D, Weale ME, Hernandez D, Crehan H, Gibbs JR, Mayeux R, Haines JL, Farrer LA, Pericak-Vance MA, Schellenberg GD, Ramirez-Restrepo M, Engel A, Myers AJ, Corneveaux JJ, Huentelman MJ, Dillman A, Cookson MR, Reiman EM, Singleton A, Hardy J, Guerreiro R, ADGC Collaborators. Initial assessment of the pathogenic mechanisms of the recently identified Alzheimer risk Loci. Annals Human Genetics, 77:85-105, 2013, PMC3578142.

200.   Hsiao JJ, Lee GJ, Lu PH, Teng E. Longitudinal declines in instrumental activities of daily living in stable and progressive mild cognitive impairment. Neurology, 80:P07.154, 2013. (Abstract)

201.   Hutchinson KS. Risk factors for apathy in Alzheimer's disease. Doctoral Dissertation, Fielding Graduate University, submitted 2013.

202.   Jicha G, Nelson P, Fardo D, Kryscio R, Schmitt F, Smith C, Neltner J, Van Eldik L, Kukull W, Abner E. Vascular neuropathology in dementia patients receiving antipsychotic therapy. Alzheimers and Dementia, 9:P303, 2013. (Abstract)

203.   Joshi A, Teng E, Tassniyom K, Shapira JS, Mendez MF. Hippocampal and medial temporal sclerosis in behavioral variant frontotemporal dementia. Neurology, 80:S44.007, 2013. (Abstract)

204.   Kalapatapu RK, Delucchi KL. APOE e4 genotype and cigarette smoking in adults with normal cognition and mild cognitive impairment: a retrospective baseline analysis of a national dataset. Am J Drug Alcohol Abuse, 39:219-226, 2013, PMC3710309.

205.   Kaur B, Harvey DJ, DeCarli CS, Zhang L, Sabbagh MN, Olichney JM. Extrapyramidal signs by dementia severity in Alzheimer disease and dementia with Lewy bodies. Alzheimer Dis Assoc Disord, 27:226-232, 2013, PMC3562426.

206.   Koepsell TD, Gill DP, Chen B. Stability of Clinical Etiologic Diagnosis in Dementia and Mild Cognitive Impairment: Results from a Multi-Center Longitudinal Database. Am J Alzheimers Dis Other Demen, 28:750-758, 2013, PMC3876285.

207.   Kremen S, Tassniyom K, Mendez M, Teng E. Extrapyramidal Signs in Primary Progressive Aphasia: Analyses of the NACC UDS Cohort. Neurology, 80:P06.071, 2013. (Abstract)

208.   Kukull W, Monsell S, Besser L, Bristow K, Beekly D, Mock C, Hawes H. Comparison of Motor Symptoms in MCI by Underlying Disease Process. Neurodegener Dis, 11(S1), 2013. (Abstract)

209.   Lambert JC, Ibrahim-Verbaas CA, Harold D, Naj AC, Sims R, Bellenguez C, Jun G, Destefano AL, Bis JC, Beecham GW, Grenier-Boley B, Russo G, Thornton-Wells TA, Jones N, Smith AV, Chouraki V, Thomas C, Ikram MA, Zelenika D, Vardarajan BN, Kamatani Y, Lin CF, Gerrish A, Schmidt H, Kunkle B, Dunstan ML, Ruiz A, Bihoreau MT, Choi SH, Reitz C, Pasquier F, Hollingworth P, Ramirez A, Hanon O, Fitzpatrick AL, Buxbaum JD, Campion D, Crane PK, Baldwin C, Becker T, Gudnason V, Cruchaga C, Craig D, Amin N, Berr C, Lopez OL, De Jager PL, Deramecourt V, Johnston JA, Evans D, Lovestone S, Letenneur L, Moron FJ, Rubinsztein DC, Eiriksdottir G, Sleegers K, Goate AM, Fievet N, Huentelman MJ, Gill M, Brown K, Kamboh MI, Keller L, Barberger-Gateau P, McGuinness B, Larson EB, Green R, Myers AJ, Dufouil C, Todd S, Wallon D, Love S, Rogaeva E, Gallacher J, St George-Hyslop P, Clarimon J, Lleo A, Bayer A, Tsuang DW, Yu L, Tsolaki M, Bossu P, Spalletta G, Proitsi P, Collinge J, Sorbi S, Sanchez-Garcia F, Fox NC, Hardy J, Naranjo MC, Bosco P, Clarke R, Brayne C, Galimberti D, Mancuso M, Matthews F, Moebus S, Mecocci P, Del Zompo M, Maier W, Hampel H, Pilotto A, Bullido M, Panza F, Caffarra P, Nacmias B, Gilbert JR, Mayhaus M, Lannfelt L, Hakonarson H, Pichler S, Carrasquillo MM, Ingelsson M, Beekly D, Alvarez V, Zou F, Valladares O, Younkin SG, Coto E, Hamilton-Nelson KL, Gu W, Razquin C, Pastor P, Mateo I, Owen MJ, Faber KM, Jonsson PV, Combarros O, O'Donovan MC, Cantwell LB, Soininen H, Blacker D, Mead S, Mosley TH, Jr., Bennett DA, Harris TB, Fratiglioni L, Holmes C, de Bruijn RF, Passmore P, Montine TJ, Bettens K, Rotter JI, Brice A, Morgan K, Foroud TM, Kukull WA, Hannequin D, Powell JF, Nalls MA, Ritchie K, Lunetta KL, Kauwe JS, Boerwinkle E, Riemenschneider M, Boada M, Hiltunen M, Martin ER, Schmidt R, Rujescu D, Wang LS, Dartigues JF, Mayeux R, Tzourio C, Hofman A, Nothen MM, Graff C, Psaty BM, Jones L, Haines JL, Holmans PA, Lathrop M, Pericak-Vance MA, Launer LJ, Farrer LA, van Duijn CM, Van Broeckhoven C, Moskvina V, Seshadri S, Williams J, Schellenberg GD, Amouyel P. Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease. Nature Genetics, 45:1452-1458, 2013, PMC3896259.

210.   Lane EM, Liu D, Lu Z, Niswender KD, Jefferson AL. The Differential Impact of Diabetes Medications on Cognition. Alzheimers and Dementia, 9:P206, 2013. (Abstract)

211.   Li B, Chow TWS, Huang D. A novel feature selection method and its application. J Intell Inf Syst, 41:235-268, 2013, PMC4269276.

212.   Liu D, Zhou A. ROC Analysis in Biomarker Combination with Covariate Adjustment. Academic Radiology, 20:874-882, 2013, PMC3682803.

213.   Liu D, Zhou XH. Covariate adjustment in estimating the area under ROC curve with partially missing gold standard. Biometrics, 69:91-100, 2013, PMC3622116.

214.   Liu W, Zhang B, Zhang Z, Zhou XH. Joint Modeling of Transitional Patterns of Alzheimer's Disease. PLoS ONE, 8:e75487, 2013, PMC3779177.

215.   Macklin EA, Blacker D, Hyman BT, Betensky RA. Improved Design of Prodromal Alzheimer's Disease Trials through Cohort Enrichment and Surrogate Endpoints. J Alzheimers Dis, 36:475-486, 2013, PMC3779898.

216.   Mendez MF, Joshi A, Tassniyom K, Teng E, Shapira JS. Clinicopathological Differences Among Patients with Clinical Behavioral Variant Frontotemporal Dementia. Neurology, 80:561-568, 2013, PMC3589292.

217.   Meranus D, Kukull W. Antithrombotic medication use and dementia incidence in a longitudinal cohort with mild cognitive impairment and atrial fibrillation. Alzheimers and Dementia, 9:P612, 2013. (Abstract)

218.   Mez J, Cosentino S, Brickman AM, Huey ED, Manly JJ, Mayeux R. Dysexecutive versus amnestic Alzheimer disease subgroups: analysis of demographic, genetic, and vascular factors. Alzheimer Dis Assoc Disord, 27:218-225, 2013, PMC3748394.

219.   Mez J, Cosentino S, Brickman AM, Huey ED, Manly JJ, Mayeux R. Faster cognitive and functional decline in Dysexecutive versus amnestic Alzheimer's subgroups: a longitudinal analysis of the National Alzheimer's Coordinating Center (NACC) database. PLoS ONE, 8:e65246, 2013, PMC3670903.

220.   Mez J, Cosentino S, Brickman AM, Huey ED, Mayeux R. Different demographic, genetic, and longitudinal traits in language versus memory Alzheimer's disease subgroups. J Alzheimers Dis, 37:137-146, 2013, PMC3877683.

221.   Miyashita A, Koike A, Jun G, Wang LS, Takahashi S, Matsubara E, Kawarabayashi T, Shoji M, Tomita N, Arai H, Asada T, Harigaya Y, Ikeda M, Amari M, Hanyu H, Higuchi S, Ikeuchi T, Nishizawa M, Suga M, Kawase Y, Akatsu H, Kosaka K, Yamamoto T, Imagawa M, Hamaguchi T, Yamada M, Moriaha T, Takeda M, Takao T, Nakata K, Fujisawa Y, Sasaki K, Watanabe K, Nakashima K, Urakami K, Ooya T, Takahashi M, Yuzuriha T, Serikawa K, Yoshimoto S, Nakagawa R, Kim JW, Ki CS, Won HH, Na DL, Seo SW, Mook-Jung I, St George-Hyslop P, Mayeux R, Haines JL, Pericak-Vance MA, Yoshida M, Nishida N, Tokunaga K, Yamamoto K, Tsuji S, Kanazawa I, Ihara Y, Schellenberg GD, Farrer LA, Kuwano R. SORL1 is genetically associated with late-onset Alzheimer's disease in Japanese, Koreans and Caucasians. PLoS ONE, 8:e58618, 2013, PMC3614978.

222.   Monsell SE, Mock C, Roe CM, Ghoshal N, Morris JC, Cairns NJ, Kukull W. Comparison of symptomatic and asymptomatic persons with Alzheimer's disease neuropathology. Neurology, 80:2121-2129, 2013, PMC3716351.

223.   Monsell SM, Bristow KE, Besser LM, Checkoway H, Litvan I, Kukull WA. APOE e4 and clinical progression in Parkinson's disease. Alzheimers and Dementia, 9:P738-739, 2013. (Abstract)

224.   Obermann KR, Morris JC, Roe CM. Exploration of 100 commonly used drugs and supplements on cognition in older adults. Alzheimers and Dementia, 9:724-732, 2013, PMC3823812.

225.   Piper BJ, Yasen AL, Taylor AE, Ruiz JR, Gaynor JW, Dayger CA, Gonzalez-Gross M, Kwon OD, Nilsson LG, Day IN, Raber J, Miller JK. Non-replication of an association of Apolipoprotein E2 with sinistrality. Laterality, 18:251-261, 2013, PMC3770935.

226.   Qiu WQ, Mwamburi M, Besser LM, Zhu H, Li H, Wallack M, Phillips L, Qiao L, Budson AE, Stern R, Kowall N. Angiotensin Converting Enzyme Inhibitors and the Reduced Risk of Alzheimer's disease in the Absence of Apoliprotein E4 allele. J Alzheimers Dis, 37:421-428, 2013, PMC3873370.

227.   Reitz C, Jun G, Naj A, Rajbhandary R, Vardarajan BN, Wang LS, Valladares O, Lin CF, Larson EB, Graff-Radford NR, Evans D, De Jager PL, Crane PK, Buxbaum JD, Murrell JR, Raj T, Ertekin-Taner N, Logue M, Baldwin CT, Green RC, Barnes LL, Cantwell LB, Fallin MD, Go RC, Griffith P, Obisesan TO, Manly JJ, Lunetta KL, Kamboh MI, Lopez OL, Bennett DA, Hendrie H, Hall KS, Goate AM, Byrd GS, Kukull WA, Foroud TM, Haines JL, Farrer LA, Pericak-Vance MA, Schellenberg GD, Mayeux R, ADGC Collaborators. Variants in the ATP-binding cassette transporter (ABCA7), apolipoprotein E 4,and the risk of late-onset Alzheimer disease in African Americans. JAMA, 309:1483-1492, 2013, PMC3667653.

228.   Reitz C, Tosto G, Vardarajan B, Rogaeva E, Ghani M, Rogers RS, Conrad C, Haines JL, Pericak-Vance MA, Fallin MD, Foroud T, Farrer LA, Schellenberg GD, George-Hyslop PS, Mayeux R, ADGC Collaborators. Independent and epistatic effects of variants in VPS10-d receptors on Alzheimer disease risk and processing of the amyloid precursor protein (APP). Translational Psychiatry, 3:e256, 2013, PMC3669917.

229.   Ridge PG, Mukherjee S, Crane P, Kauwe JSK, ADGC Collaborators. Alzheimer's Disease: Analyzing the Missing Heritability. PLoS ONE, 8:e79771, 2013, PMC3820606.

230.   Rosenberg PB, Mielke MM, Appleby BS, Oh ES, Geda YE, Lyketsos CG. The Association of Neuropsychiatric Symptoms in MCI with Incident Dementia and Alzheimer's Disease. Am J Geriatr Psychiatry, 21:685-695, 2013, PMC3428504.

231.   Sachs MC, Zhou XH. Partial summary measures of the predictiveness curve. Biometrical Journal, 55:589-602, 2013, PMC3806283.

232.   Sayed N, Culver C, Dams-O'Connor K, Hammond F, Diaz-Arrastia R. Clinical phenotype of dementia after traumatic brain injury. J Neurotrauma, 30:1117-1122, 2013, PMC3705947.

233.   Sayegh P, Knight BG. Assessment and diagnosis of dementia in Hispanic and non-Hispanic white outpatients. Gerontologist, 53:760-769, 2013, PMC3771673.

234.   Serrano-Pozo A, Qian J, Monsell SE, Frosch MP, Betensky RA, Hyman BT. Examination of the clinicopathologic continuum of Alzheimer disease in the autopsy cohort of the National Alzheimer Coordinating Center. J Neuropathol Exp Neurol, 72:1182-1192, 2013, PMC3962953.

235.   Sherva R, Gross AL, Mukherjee SR, Newhouse S, Kauwe J, Munsie L, Saykin AJ, Bennett DA, Chibnik LB, DeJager P, Kraft P, Crane PK, Green RC. GWAS of Rate of Cognitive Decline in Six AD Cohorts. 63rd Annual Meeting of The American Society of Human Genetics, Boston MA, 2013. (Abstract)

236.   Shim YS, Roe CM, Buckles VD, Morris JC. Clinicopathologic Study of Alzheimer's Disease: Alzheimer Mimics. J Alzheimers Dis, 35:799-811, 2013, PMC3725959.

237.   Spackman DE, Kadiyala S, Neumann PJ, Veenstra DL, Sullivan SD. The Validity of Dependence as a Health Outcome Measure in Alzheimer's Disease. Am J Alzheimers Dis Other Demen, 28:245-252, 2013, PMC3690581.

238.   Steenland K, Zhao L, Goldstein FC, Levey A. Statins and cognitive decline in older adults with normal cognition or mild cognitive impairment. J Am Geriatr Soc, 61:1449-1455, 2013, PMC3773248.

239.   Sullivan C, Rabins PV, Brandt J, Onyike CU. Cognitive and Behavioral Features of Neuropathology-defined Hippocampal Sclerosis Dementia. Neurology, submitted 2013.

240.   Thambisetty M, An Y, Tanaka T. Alzheimer's disease risk genes and the age-at-onset phenotype. Neurobiol Aging, 34:2696.e1-2696.e5, 2013, PMC4038407.

241.   Toledo JB, Arnold SE, Brettschneider J, Lee EB, Xie SX, Grossman M, Monsell SM, Kukull WA, Trojanowski JQ. Importance of coincident neurodegenerative diseases. Alzheimers and Dementia, 9:P334, 2013. (Abstract)

242.   Toledo JB, Arnold SE, Raible K, Brettschneider J, Xie SX, Grossman M, Monsell SE, Kukull WA, Trojanowski JQ. Contribution of cerebrovascular disease in autopsy confirmed neurodegenerative disease cases in the National Alzheimer's Coordinating Centre. Brain, 136:2697-2706, 2013, PMC3858112.

243.   Trzepacz PT, Saykin A, Yu P, Bhamditipati P, Sun J, Dennehy EB, Willis B, Cummings JL. Subscale validation of the neuropsychiatric inventory questionnaire: comparison of Alzheimer's disease neuroimaging initiative and national Alzheimer's coordinating center cohorts. Am J Geriatr Psychiatry, 21:607-622, 2013, PMC3913908.

244.   Tsuang D, Leverenz JB, Lopez OL, Hamilton RL, Bennett DA, Schneider JA, Buchman AS, Larson EB, Crane PK, Kaye JA, Kramer P, Woltjer R, Trojanowski JQ, Weintraub D, Chen-Plotkin AS, Irwin DJ, Rick J, Schellenberg GD, Watson S, Kukull W, Nelson PT, Jicha GA, Neltner JH, Galasko D, Masliah E, Quinn JF, Chung KA, Yearout D, Mata IF, Wan JY, Edwards KL, Montine TJ, Zabetian CP. APOE ε4 Increases Risk for Dementia in Pure Synucleinopathies. JAMA Neurology, 70:223-228, 2013, PMC3580799.

245.   Wallack M, Zhu H, Mwamburi M, Phillips LE, Budson A, Kowall N, Stern R, Qiu WQ. Apolipoprotein E Allele, Angiotensin-Converting Enzyme and its inhibitors, in the Development of Alzheimer's Disease. Alzheimers and Dementia, 9:P616-617, 2013. (Abstract)

246.   Wang L, Zhou X-H. Causal Inference with Truncation by Death in Observational Study. The Western North American Region of the International Biometric Society Annual Meeting, Los Angeles, CA, 2013. (Abstract)

247.   Wang L, Zhou XH, Kukull W. Are some individuals immune to dementia?. Alzheimers and Dementia, 9:P617-618, 2013. (Abstract)

248.   Wang Z, Zhou A. Latent class regression model for assessment of diagnostic tests in the absence of a gold standard, with accommodation for covariate information. Joint Statistical Meeting Montreal, Canada, 2013. (Abstract)

249.   Wangoria E, Wordoffa H. Alzheimer's Disease Stage Prediction using Machine Learning and Multi Agent System. Thesis, Blekinge Inst of Tech, School of Computing, 2013.

250.   Wyman-Chick K. Clinical Utility of the Clinical Dementia Rating Scale for Parkinson's Disease Dementia. A Dissertation Submitted to the Faculty of the School of Professional Psychology, Pacific Univeristy, Hillsboro, Oregon, 2013.

251.   Xie Y, Zimmerman DL. Antedependence models for nonstationary categorical longitudinal data with ignorable missingness: likelihood-based inference. Stat Med, 32:3274-3289, 2013, PMC3885186.

252.   Zhao MB, Chan RHM, Tang P, Chow TWS, Wong SWH. Trace Ratio Linear Discriminant Analysis for Medical Diagnosis: A Case Study of Dementia. IEEE Signal Processing Letters, 20:431-434, 2013, PMC3784002.

253.   Zhu JY, Vandermorris S, Craik FIM. Digit Symbol Substitution as a Marker of Asymptomatic AD. J Int Neuropsychol Soc, 19(S1):222, 2013. (Abstract)

 
         2012
254.   Allen M, Zou F, Chai HS, Younkin CS, Crook J, Pankratz VS, Carrasquillo MM, Rowley CN, Nair AA, Middha S, Maharjan S, Nguyen T, Ma L, Malphrus KG, Palusak R, Lincoln S, Bisceglio G, Georgescu C, Schultz D, Rakhshan F, Kolbert CP, Jen J, Haines JL, Mayeux R, Pericak-Vance MA, Farrer LA, Schellenberg GD, Petersen RC, Graff-Radford NR, Dickson DW, Younkin SG, Ertekin-Taner N.. Novel late-onset Alzheimer disease loci variants associate with brain gene expression. Neurology, 79:221-228, 2012, PMC3398432.

255.   Banks S, Leger G. Neuropsychiatric symptom profile differs based on pathology in patients with clinically diagnosed frontotemporal dementia. Dement Geriatr Cogn Disord, 34 (Suppl 1):213, 2012. (Abstract)

256.   Beach T, Monsell S, Phillips L, Kukull W. Accuracy of the Clinical Diagnosis of Alzheimer's Disease at National Institute on Aging Alzheimer's Disease Centers, 2005-2010. J Neuropathol Exp Neurol, 71:266-273, 2012, PMC3331862.

257.   Beekly D, Monsell S, Besser L, Gill D, Robichaud E, Knopman D, Kukull W. The NACC FTLD Module data. Dement Geriatr Cogn Disord, 34 (Suppl 1), 2012. (Abstract)

258.   Besser LM, Monsell S, Kukull WA. Comparison of Neuropsychological Test Scores among English and Spanish Speakers in a Multi-regional Sample of Cognitively Normal Subjects. Alzheimers and Dementia, 8:P548, 2012. (Abstract)

259.   Bhatta R, Chou SY, Cantwell L, Schellenberg G, Wang LS. Alzheimer's Disease and toxicity exposure: a gene-environment interactions analysis. American Society for Health Economics Conference Minneapolis, MN June, 2012. (Abstract)

260.   Brenowitz W, Monsell S, Gill D, Kukull W. Neuropsychiatric symptoms in mild Alzheimer's disease: the influence of research study informants. Alzheimers and Dementia, 8:P382-P383, 2012. (Abstract)

261.   Chen B, Qin J. A new estimation with minimum trace of asymptotic covariance matrix for incomplete longitudinal data with a surrogate process. Stat Med, in press 2012, PMC3808493.

262.   Chen B, Zhou A. A Latent-Variable Marginal Method for Multi-Level Incomplete Binary Data. Stat Med, 31:3211-3222, 2012, PMC3631603.

263.   Chen B, Yi G, Cook R, Zhou XH. Marginal Methods for Clustered Longitudinal Binary Data with Incomplete Covariates. J of Stat Planning and Inference, 142:2819-2831, 2012, PMC3690662.

264.   Coppola G, Chinnathambi S, Lee JJ, Dombroski BA, Baker MC, Soto-Ortolaza AI, Lee SE, Klein E, Huang AY, Sears R, Lane JR, Karydas AM, Kenet RO, Biernat J, Wang LS, Cotman CW, Decarli CS, Levey AI, Ringman JM, Mendez MF, Chui HC, Le Ber I, Brice A, Lupton MK, Preza E, Lovestone S, Powell J, Graff-Radford N, Petersen RC, Boeve BF, Lippa CF, Bigio EH, Mackenzie I, Finger E, Kertesz A, Caselli RJ, Gearing M, Juncos JL, Ghetti B, Spina S, Bordelon YM, Tourtellotte WW, Frosch MP, Vonsattel JP, Zarow C, Beach TG, Albin RL, Lieberman AP, Lee VM, Trojanowski JQ, Van Deerlin VM, Bird TD, Galasko DR, Masliah E, White CL, Troncoso JC, Hannequin D, Boxer AL, Geschwind MD, Kumar S, Mandelkow EM, Wszolek ZK, Uitti RJ, Dickson DW, Haines JL, Mayeux R, Pericak-Vance MA, Farrer LA, ADGC Collaborators, Ross OA, Rademakers R, Schellenberg GD, Miller BL, Mandelkow E, Geschwind DH. Evidence for a role of the rare p.A152T variant in MAPT in increasing the risk for FTD-spectrum and Alzheimer's diseases. Hum Mol Genet, 21:3500-3512, 2012, PMC3392107.

265.   Gavett BE. Dementia has a Categorical, not Dimensional, Latent Structure. Psychol Aging, 27:791-797, 2012, PMC3445289.

266.   Gill DP, Hubbard RA, Koepsell TD, Knopman DS, Kukull WA. Sex differences in rate of progression of three dementia types. Alzheimers and Dementia, 8:P622-P623, 2012. (Abstract)

267.   Grill JD, Monsell S, Karlawish J. Are patients whose study partners are spouses more likely to be eligible for Alzheimer's disease clinical trials?. Dement Geriatr Cogn Disord, 33:334-340, 2012, PMC3477789.

268.   Gustafson DR, Gill DP, Monsell SE. Evaluating sex differences and vascular morbidities in relation to global cognitive function in incident Alzheimer's disease. Alzheimers and Dementia, 8:P496, 2012. (Abstract)

269.   Hajjar I, Brown L, Mack W, Chui H. Impact of angiotensin receptor blockers on Alzheimer's disease neuropathology in a large brain autopsy series. Arch Neurol, 69:1632-1638, 2012, PMC3608189.

270.   Hyman BT, Phelps CH, Beach TG, Bigio EH, Cairns NJ, Carrillo MC, Dickson DW, Duyckaerts C, Frosch MP, Masliah E, Mirra SS, Nelson PT, Schneider JA, Thal DR, Thies B, Trojanowski JQ, Vinters HV, Montine TJ. National Institute on Aging-Alzheimer's Association guidelines for the neuropathologic assessment of Alzheimer's disease. Alzheimers and Dementia, 8:1-13, 2012, PMC3266529.

271.   Jefferson AL, Sparling J, Gifford K, Cantwell N, Martin B, Tripodis Y. An elevated vascular health index is related to worse cognitive performance in individuals with mild cognitive impairment. Int'l Neuropsychological Society Meeting, 2012. (Abstract)

272.   Jun G, Vardarajan BN, Buros J, Yu CE, Hawk MV, Dombroski BA, Crane PK, Larson EB. Comprehensive search for Alzheimer disease susceptibility loci in the APOE region. Arch Neurol, 69:1270-1279, 2012, PMC3579659.

273.   Knopman D, Weintraub S, Pankratz VS. Augmented (8-item) Clinical Dementia Rating Scale is an effective instrument for longitudinal studies of bvFTD and PPA. Dement Geriatr Cogn Disord, 34 (Suppl 1):21-22, 2012. (Abstract)

274.   Koepsell TD, Monsell SE. Reversion from mild cognitive impairment to normal or near-normal cognition: risk factors and prognosis. Neurology, 79:1591-1598, 2012, PMC3475624.

275.   Kukull WA, Ganguli M. Generalizability: The trees, the forest, and the low-hanging fruit.. Neurology, 78:1886-1891, 2012, PMC3369519.

276.   Kukull WA. An apple a day to prevent Parkinson disease: reduction of risk by flavonoids. Neurology, 78:1112-1113, 2012.

277.   Kukull W, Knopman D, Mesulam M, Grossman M, Miller B, Weintraub S, Kramer J, Rankin K, Rosen H, Hillis A, Boeve B, Mendez M, Phelps C, Morris J. Standardized data collection and diagnostic formulation for FTLD Clinical Exam: The FTLD Module. Dement Geriatr Cogn Disord, 34 (Suppl 1), 2012. (Abstract)

278.   Lee GJ, Elashoff D, Di LJ, Teng E, Melchor S, Lu PH. Age-Associated Memory Impairment Increases Risk of Conversion to MCI and Dementia. Alzheimers and Dementia, 8:P544, 2012. (Abstract)

279.   Mendez M, Joshi A, Tassniyom K, Teng E. Clinicopathological differences among patients meeting clinical criteria for behavioral variant frontotemporal dementia. Dement Geriatr Cogn Disord, 34 (Suppl 1):260-261, 2012. (Abstract)

280.   Meranus D, Monsell S, Thomas G, Kukull W. Cholinesterase Inhibitors and Memantine Use in the National Alzheimer's Coordinating Center's Uniform Data Set: A Longitudinal Assessment of Real-World Medication Use in Dementia. Alzheimers and Dementia, 8:P711, 2012. (Abstract)

281.   Mez J, Consentino S, Brickman A, Huey E, Manley J, Mayeux R. Cognitive and functional decline in dysexecutive versus amnestic Alzheimer's. Alzheimers and Dementia, 8:P635-P636, 2012. (Abstract)

282.   Mez J, Cosentino S, Brickman A, Huey E, Manly J, Mayeux R. Characterization of Dysexecutive Versus Amnestic Alzheimer's Disease Phenotypes in the National Alzheimer's Coordinating Center (NACC) Database. Neurology, 78(S), 2012. (Abstract)

283.   Monsell SE, Liu D, Weintraub S, Kukull WA. Comparing measures of decline to dementia in amnestic MCI subjects in the National Alzheimer's Coordinating Center (NACC) Uniform Data Set. Int Psychogeriatr, 24:1553-1560, 2012, PMC3614357.

284.   Montine TJ, Phelps CH, Beach TG, Bigio EH, Cairns NJ, Dickson DW, Duyckaerts C, Frosch MP, Masliah E, Mirra SS, Nelson PT, Schneider JA, Thal DR, Trojanowski JQ, Vinters HV, Hyman BT. National Institute on Aging-Alzheimer's Association guidelines for the neuropathologic assessment of Alzheimer's disease: a practical approach. Acta Neuropathol, 123:1-11, 2012, PMC3268003.

285.   Morris JC. Revised criteria for Mild Cognitive Impairment may compromise the diagnosis of Alzheimer Disease dementia. Arch Neurol, 69:700-708, 2012, PMC3423496.

286.   Nandipati S, Luo X, Schimming C, Grossman H, Sano M. Cognition in Non-Demented Diabetic Older Adults. Curr Aging Science, 5:131-135, 2012, PMC3659164.

287.   Nelson PT, Alafuzoff I, Bigio EH, Bouras C, Braak H, Cairns NJ, Castellani RJ, Crain BJ, Davies P, Del Tredici K, Duyckaerts C, Frosch MP, Haroutunian V, Hof PR, Hulette CM, Hyman BT, Iwatsubo T, Jellinger KA, Jicha GA, Kovari E, Kukull WA, Leverenz JB, Love S, Mackenzie IR, Mann DM, Masliah E, McKee AC, Montine TJ, Morris JC, Schneider JA, Sonnen JA, Thal DR, Trojanowski JQ, Troncoso JC, Wisniewski T, Woltjer RL, Beach TG. Correlation of Alzheimer's Disease Neuropathologic Changes with Cognitive Status: a Review of the Literature. J Neuropathol Exp Neurol, 71:362-381, 2012, PMC3560290.

288.   Olchanski N, Lin PJ, Cohen JT, Neumann PJ. Alzheimer's disease progression rates: new estimates. American Neurological Association Annual Meeting in Boston, MA, Oct 8, 2012. (Abstract)

289.   Pirraglia E, Lobach I, De Santi S, Karantzoulis S, Glodzik L, de Leon MJ. A Comparison of Methods for Deriving Normative Scores for Evaluating Cognitive Impairment. Alzheimers and Dementia, 8:P541-P542, 2012. (Abstract)

290.   Pirraglia E, Murray J, De Santi S, Mosconi L, Glodzik L, de Leon MJ. Maternal History and Impaired Memory Predicts Future Decline to Dementia in Cognitively Normal Individuals. Alzheimers and Dementia, 8:P542, 2012. (Abstract)

291.   Sadak T, Katon J, Borson S. Defining Dementia Multimorbidity in a National Sample. J Am Geriatr Soc1, 60:S62, 2012. (Abstract)

292.   Sadak T, Katon J, Borson S. Multimorbidity in Alzheimer's Disease and Related Dementias. Alzheimers and Dementia, 8:P490-P491, 2012. (Abstract)

293.   Sadak T, Kukull W, Borson S, Logsdon R, Cochrane B, Herting J. Multidimensional Complexity in the Dementias: Diagnosis, Stage, Comorbidity, and Neuropsychiatric Symptoms. Neurology, 78(S), 2012. (Abstract)

294.   Sayed N, Culver C, Hammond R, Diaz-Arrastia R. Clinical and Pathologic Phenotype of Dementia after Traumatic Brain Injury. National Neurotrauma Society, 2012. (Abstract)

295.   Sayegh P, Knight BG. Assessing the Cross-Cultural Measurement Properties of the Neuropsychiatric Inventory Questionnaire. Gerontological Society of America 65th Annual Scientific Meeting, San Diego, CA, 2012. (Abstract)

296.   Sayegh P, Knight BG. The Functional Assessment Questionnaire: Measurement Properties in Hispanics and Non-Hispanic Whites. Gerontological Society of America 65th Annual Scientific Meeting, San Diego, CA, 2012. (Abstract)

297.   Spackman DE, Kadiyala S, Neumann PJ, Veenstra DL, Sullivan SD. Measuring Alzheimer disease progression with transition probabilities: Estimates from NACC-UDS. Curr Alzheimer Res, 9:1050-1058, 2012, PMC3690579.

298.   Spering CC, Hobson V, Lucas JA, Menon CV, Hall JR, O'Bryant SE. Diagnostic accuracy of the MMSE in detecting probable and possible Alzheimer's disease in ethnically diverse highly educated individuals: an analysis of the NACC database. J Gerontol, 67:890-896, 2012, PMC3403860.

299.   Spiegel R. Modeling the Course of AD: Contributions to Better Clinical Trials. J Nutr Health Aging, 811-812, 2012. (Abstract)

300.   Steenland K, Karnes C, Seals R, Carnevale C, Hermida A, Levey A. Late-life depression as a risk factor for mild cognitive impairment or Alzheimer's disease in 30 US Alzheimer's disease centers. J Alzheimers Dis, 31:265-275, 2012, PMC3729228.

301.   Sullivan C, Onyike C, Brandt J. The clinical features of neuropathology-confirmed Hippocampal Sclerosis Dementia. 41st mtg Intl Neuropsychological Society, 2012. (Abstract)

302.   Teng E, Tassniyom K, Lu PH. Reduced quality-of-life ratings in mild cognitive impairment: analyses of subject and informant responses. Am J Geriatr Psychiatry, 20:1016-1025, 2012, PMC3513348.

303.   Whitcomb DC, LaRusch J, Krasinskas AM, Klei L, Smith JP, Brand RE, Neoptolemos JP, Lerch MM, Tector M, Sandhu BS, Guda NM, Orlichenko L, Alkaade S, Amann ST, Anderson MA, Baillie J, Banks PA, Conwell D, Cote GA, Cotton PB, DiSario J, Farrer LA, Forsmark CE, Johnstone M, Gardner TB, Gelrud A, Greenhalf W, Haines JL, Hartman DJ, Hawes RA, Lawrence C, Lewis M, Mayerle J, Mayeux R, Melhem NM, Money ME, Muniraj T, Papachristou GI, Pericak-Vance MA, Romagnuolo J, Schellenberg GD, Sherman S, Simon P, Singh VP, Slivka A, Stolz D, Sutton R, Weiss FU, Wilcox CM, Zarnescu NO, Wisniewski SR, O'Connell MR, Kienholz ML, Roeder K, Barmada MM, Yadav D, Devlin B. Common genetic variants in the CLDN2 and PRSS1-PRSS2 loci alter risk for alcohol-related and sporadic pancreatitis. Nature Genetics, 44:1349-1354, 2012, PMC3510344.

304.   Wingo TS, Lah JL, Levey AI, Cutler DJ. Autosomal Recessive Causes Likely in Early-Onset Alzheimer Disease. Arch Neurol, 69:59-64, 2012, PMC3332307.

305.   Zhou XH, Duan X. Quantile Regression-based Covariate-Specific ROC Curves. WFN Annual Regional North American Meeting, 2012. (Abstract)

306.   Zou F, Chai HS, Younkin CS, Crook J, Pankratz VS, Allen M, Carrasquillo MM, Rowley CN, Nair AA, Middha S, Maharjan S, Nguyen T, Ma L, Malphrus KG, Palusak R, Lincoln S, Bisceglio G, Georgescu C, Kouri N, Kolbert CP, Jen J, Haines JL, Mayeux R, Pericak-Vance MA, Farrer LA, Schellenberg GD, ADGC Collaborators , Petersen RC, Graff-Radford NR, Dickson DW, Younkin SG, Ertekin-Taner N. Brain Expression Genome-Wide Association Study (eGWAS) Identifies Human Disease-Associated Variants. PLoS genetics, 8:e1002707, 2012, PMC3369937.

 
         2011
307.   Abner EL, Kryscio JR, Schmitt FA, Frederick A, Santacruz KA, Jicha GA, Lin Y, Neltner JM, Smith CD, Charles D, Van Eldik LJ, Linda J, Nelson PT. "End-stage" neurofibrillary tangle pathology in preclinical Alzheimer's disease-fact or fiction. J Alzheimers Dis, 25:445-453, 2011, PMC3171001.

308.   Beach T, Monsell S, Phillips L, Kukull WA. Comparison of Clinical and Neuropathological Definitions of Alzheimer's Disease at National Institute on Aging Alzheimer's Disease Centers, 2005-2010. Alzheimers and Dementia, 7:S525, 2011. (Abstract)

309.   Bliwise DL, Mercaldo ND, Avidan AY, Boeve BF, Greer SA, Kukull WA. Sleep disturbance in dementia with lewy bodies and Alzheimer's disease: a multicenter analysis. Dement Geriatr Cogn Disord, 31:239-246, 2011, PMC3085031.

310.   Bloudek LM, Spackman DE, Veenstra DL, Sullivan SD. CDR State Transition Probabilities in Alzheimer's Disease with an without Cholinesterase Inhibitor Intervention in an Observational Cohort. J Alzheimers Dis, 24:599-607, 2011, PMC3593724.

311.   Carrasquillo M, Olivia B, Talisha H, Ma L, Bisceglio G, Zou F, Crook J, Pankratz V, Sando S, Aasly J, Barcikowska M, Wszolek Z, Dickson D, Graff-Radford N, Petersen R, Morgan K, Younkin S. Replication of LOAD GWAS Associations. Alzheimers and Dementia, 7:S179, 2011. (Abstract)

312.   Chen B, Zhou A. Doubly Robust Estimates for Binary Longitudinal Data Analysis with Missing Response and Missing Covariates. Biometrics, 67:830-842, 2011, PMC3652597.

313.   Chen B, Zhou XHA. Non-Homogeneous Markov Process Models with Informative Observation Times, with an Application to Alzheimer's Disease. Alzheimers and Dementia, 7:S366, 2011. (Abstract)

314.   Chen B, Zhou XH. Non-homogeneous Markov process models with informative observations with an application to Alzheimer's disease. Biometrical J, 53:444-463, 2011, PMC3631600.

315.   Demichele-Sweet MA, Lopez OL, Sweet RA. Psychosis in Alzheimer's disease in the national Alzheimer's disease coordinating center uniform data set: clinical correlates and association with apolipoprotein e. Int J Alzheimers Dis, 2011:926597, 2011, PMC3065057.

316.   Frankel A. Patterns of Cognitive Decline by Dementia Subtype. Doctoral Dissertation, Alliant International University, Los Angeles, 2011.

317.   Gill DP, Koepsell TD, Hubbard RA, Kukull WA. Risk of decline in functional activities in dementia with lewy bodies and Alzheimer disease. Alzheimer Dis Assoc Disord, 25:17-23, 2011, PMC3053143.

318.   Hanfelt JJ, Wuu J, Sollinger AB, Greenway MC, Lah J, Levey AI, Goldstein FC. An Exploration of Subgroups of Mild Cognitive Impairment Based On Cognitive, Neuropsychiatric and Functional Features: Analysis of Data from the National Alzheimer's Coordinating Center. Am J Geriatric Psychiatry, 19:940-950, 2011, PMC3202691.

319.   Hermida A, Seals R, Levey A, Steenland K. Cognitive Decline and Depression in 29 US Alzheimer Disease Centers. Alzheimers and Dementia, 7:S349-351, 2011. (Abstract)

320.   Hubbard RA, Zhou XH. A comparison of non-homogeneous Markov regression models with application to Alzheimer's disease progression. J Applied Stat, 38:2313-2326, 2011, PMC3299197.

321.   Johnson DK, Watts A, Chapin BA, Anderson R, Burns JM. Neuropsychiatric Profiles in Dementia. Alzheimer Dis Assoc Disord, 25:326-332, 2011, PMC3218373.

322.   Jun G, Buros J, Narayan Vardarajan B, Lunetta K, Farrer LA, ADGC Collaborators. Genome-wide scan suggested novel Alzheimer disease susceptibility genes by factoring influence of APOE. Alzheimers and Dementia, 7:S186, 2011. (Abstract)

323.   Kaur B, Harvey D, DeCarli C, Sabbagh M, Olichney J. Measurable Parkinsonism in Clinically Diagnosed Alzheimer's Disease: Associated with Mixed Neuropathologies. Neurology, 76:A622, 2011. (Abstract)

324.   Knopman D, Weintraub S, Pankratz VS. Language and Behavior Domains Enhance the Value of the Clinical Dementia Rating Scale. Alzheimers and Dementia, 7:293-299, 2011, PMC3096831.

325.   Koepsell T, Monsell S. Characterizing Individuals who Revert from Mild Cognitive Impairment to Normal or Near-Normal Cognition. Alzheimers and Dementia, 7:S532, 2011. (Abstract)

326.   Koepsell T, Monsell S. Testing the First-Order Markov Assumption in Homogeneous Markov Modeling of Transition Probabilities between Cognitive States. Alzheimers and Dementia, 7:S351-352, 2011. (Abstract)

327.   Kukic V, Nan B, Wang X, Heidebrink J, Barbas N, Giordani B. Type 2 diabetes, but not hypercholesterolemia, is related to decrements in cognitive functioning among patients with MCI. Alzheimers and Dementia, 76:S270, 2011. (Abstract)

328.   Lau DT, Mercaldo ND, Shega JW, Rademaker A, Weintraub S. Functional decline associated with polypharmacy and potentially inappropriate medications in community-dwelling older adults with dementia. Am J Alzheimers Dis Other Demen, 26:606-615, 2011, PMC3298080.

329.   Liu D, Zhou A. A Model for Adjusting for Nonignorable Verification Bias in Estimation of ROC Curve and Its Area with Likelihood-Based Approach. Biometrics, 66:1119-1128, 2011, PMC3618959.

330.   Liu D, Zhou A. Semiparametric estimation of the covariate-specific ROC curve in presence of ignorable verification bias. Biometrics, 67:906-16, 2011, PMC3618959.

331.   Lu P, Saver JL, Beigi M, Vinters H, Ringman JM. Cognitive Predictors of Severe Cerebral Amyloid Angiopathy in Alzheimer's Disease Patients. Neurology, 76:A231, 2011. (Abstract)

332.   Martin ER, ADGC Collaborators. Genome-wide Association Analyses Identifies Novel Loci Associated with the Onset Age Among Cases with Late-Onset Alzheimer's Disease. Alzheimers and Dementia, 7:S188, 2011. (Abstract)

333.   Middleton LE, Grinberg LT, Miller B, Kawas C, Yaffe K. Neuropathologic features associated with Alzheimer disease diagnosis: age matters. Neurology, 77:1737-1744, 2011, PMC3208952.

334.   Monsell S, Liu D, Cosentino S, Weintraub S, Kukull WA. Comparing Global Measures of Cognitive Decline in Amnestic MCI Subjects in the National Alzheimer's Coordinating Center (NACC) Uniform Data Set. Alzheimers and Dementia, 7:S536, 2011. (Abstract)

335.   Naj AC, Jun G, ADGC Collaborators. Genome-wide Association Study of Late-Onset Alzheimer Disease Identifies Disease-Associated Variants in MS4A4/MS4A6E, CD2AP, CD33, and EPHA1. Alzheimers and Dementia, 7:S189-190, 2011. (Abstract)

336.   Naj AC, Jun G, Beecham GW, Wang LS, Vardarajan BN, Buros J, Gallins PJ, Buxbaum JD, Jarvik GP, Crane PK, Larson EB, Bird TD, Boeve BF, Graff-Radford NR, De Jager PL, Evans D, Schneider JA, Carrasquillo MM, Ertekin-Taner N, Younkin SG, Cruchaga C, Kauwe JS, Nowotny P, Kramer P, Hardy J, Huentelman MJ, Myers AJ, Barmada MM, Demirci FY, Baldwin CT, Green RC, Rogaeva E, George-Hyslop PS, Arnold SE, Barber R, Beach T, Bigio EH, Bowen JD, Boxer A, Burke JR, Cairns NJ, Carlson CS, Carney RM, Carroll SL, Chui HC, Clark DG, Corneveaux J, Cotman CW, Cummings JL, Decarli C, Dekosky ST, Diaz-Arrastia R, Dick M, Dickson DW, Ellis WG, Faber KM, Fallon KB, Farlow MR, Ferris S, Frosch MP, Galasko DR, Ganguli M, Gearing M, Geschwind DH, Ghetti B, Gilbert JR, Gilman S, Giordani B, Glass JD, Growdon JH, Hamilton RL, Harrell LE, Head E, Honig LS, Hulette CM, Hyman BT, Jicha GA, Jin LW, Johnson N, Karlawish J, Karydas A, Kaye JA, Kim R, Koo EH, Kowall NW, Lah JJ, Levey AI, Lieberman AP, Lopez OL, Mack WJ, Marson DC, Martiniuk F, Mash DC, Masliah E, McCormick WC, McCurry SM, McDavid AN, McKee AC, Mesulam M, Miller BL, Miller CA, Miller JW, Parisi JE, Perl DP, Peskind E, Petersen RC, Poon WW, Quinn JF, Rajbhandary RA, Raskind M, Reisberg B, Ringman JM, Roberson ED, Rosenberg RN, Sano M, Schneider LS, Seeley W, Shelanski ML, Slifer MA, Smith CD, Sonnen JA, Spina S, Stern RA, Tanzi RE, Trojanowski JQ, Troncoso JC, Van Deerlin VM, Vinters HV, Vonsattel JP, Weintraub S, Welsh-Bohmer KA, Williamson J, Woltjer RL, Cantwell LB, Dombroski BA, Beekly D, Lunetta KL, Martin ER, Kamboh MI, Saykin AJ, Reiman EM, Bennett DA, Morris JC, Montine TJ, Goate AM, Blacker D, Tsuang DW, Hakonarson H, Kukull WA, Foroud TM, Haines JL, Mayeux R, Pericak-Vance MA, Farrer LA, Schellenberg GD. Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer's disease. Nat Genet, 43:436-441, 2011, PMC3090745.

337.   Nelson PT, Head E, Schmitt FA, Jicha GA, Abner E, Smith CD, Van Eldik LJ, Kryscio RJ, Scheff SW. Alzheimer's disease is not ”brain aging“: neuropathological, genetic, and epidemiological human studies. Acta Neuropathol, 121:571-587, 2011, PMC3179861.

338.   Nelson PT, Schmitt FA, Lin Y, Abner EL, Jicha GA, Patel E, Thomason PC, Neltner JH, Smith CD, Santacruz KS, Sonnen JA, Poon LW, Gearing M, Green RC, Woodard JL, Van Eldik LJ, Kryscio RJ. Hippocampal sclerosis in advanced age: clinical and pathological features. Brain, 134:1506-1518, 2011, PMC3097889.

339.   Phillips LE, Roe C, Monsell SE. Age, Education and Cognitive Impairment in an Autopsy Series of Subjects with Tau-positive Neuropathological Frontotemporal Lobar Degeneration in the National Alzheimer's Coordinating Center (NACC) Da. Alzheimers and Dementia, 7:S757, 2011. (Abstract)

340.   Ringman JM, Saver JL, Beigi M, Lu P, Vinters H. Clinical Predictors of Severe Cerebral Amyloid Angiopathy in Alzheimer's Disease Patients. Neurology, 76:A662, 2011. (Abstract)

341.   Rosenberg PB, Mielke MM, Appleby B, Oh E, Leoutsakos JM, Lyketsos CG. Neuropsychiatric symptoms in MCI subtypes: the importance of executive dysfunction. Int J Geriatr Psychiatry, 26:364-372, 2011, PMC3204866.

342.   Sadak T, Borson S, Cochrane BB, Kukull W, Logsdon R, Herting JR. Dementia Diagnoses, Neuropsychiatric Symptoms and Physical Comorbidities. Western Institute of Nursing Research, 2011. (Abstract)

343.   Sayed N, Diaz-Arrastia R. Clinical and Pathologic Phenotype of Dementia after Traumatic Brain Injury (TBI). Alzheimers and Dementia, 7:S750, 2011. (Abstract)

344.   Sayegh P, Knight BG. Differences in Predictors of a Dementia Diagnosis among Hispanic and nonHispanic White Outpatients. Gerontological Society of America (GSA) Meeting November, 2011. (Abstract)

345.   Shim YS, Morris JC, Buckles VD. Clinicopathologic Study of Alzheimer's Disease: Alzheimer Mimic. World Congress of Neurology, 2011. (Abstract)

346.   Shirk SD, Mitchell MB, Shaughnessy LW, Sherman JC, Locascio JJ, Weintraub S, Atri A. A web-based normative calculator for the uniform data set (UDS) neuropsychological test battery. Alzheimer's research & therapy, 3:32, 2011, PMC3308021.

347.   Spiegel R, Berres M, Miserez AR, Monsch AU. The Placebo Group Simulation Approach (PGSA): An Alternative Study Design for Clinical Trials in Patients with Prodromal AD. CTAD Conference, San Diego November 3-5, 2011. (Abstract)

348.   Spiegel R. It really works! Confirmation of the ADNI-based Placebo Group Simulation Approach with NACC data. Alzheimers and Dementia, 7:e64, 2011. (Abstract)

349.   Stratton JH. Diagnostic Accuracy of a Binary Test in the Presence of Two Types of Missing Values. Doctoral Dissertation, University of Connecticut, 2011.

350.   Thornton-Wells TA, Torstenson ES, Dudek SM, Ritchie MD, Martin E, Pericak-Vance MA, Haines JL. Discovery and replication of gene-gene interactions in multiple independent datasets from the Alzheimer Disease Genetics Consortium. Alzheimers and Dementia, 7:S195-196, 2011. (Abstract)

351.   Vardarajan B, Jun G, Buros J, Lunetta K, Farrer LA, ADGC Collaborators. Identification of gene-gene interactions for Alzheimer disease using co-operative game theory. Alzheimers and Dementia, 7:S196, 2011. (Abstract)

352.   Wang LS, Lin CF, Schellenberg G,ADGC Collaborators. Distribution of copy number variations in Alzheimer's Disease. Alzheimers and Dementia, 7:S271, 2011. (Abstract)

353.   Wang LS, Valladares O, Lin CF, Buros J, Naj A, Farrer L, Pericak-Vance M, Schellenberg G, ADGC Collaborators. The ADGC Genome Browser. Alzheimers and Dementia, 7:S271, 2011. (Abstract)

354.   Yamout K, Mungas D, Reed BR. Cardiovascular, Cerebrovascular, and Alzheimer's Disease and Cognition in an Autopsy Sample. Neurology, 76:A74, 2011. (Abstract)

 
         2010
355.   Beekly D, Koepsell T, Phillips L, Jacka M, Hubbard J, Wu J, Morris J, Phelps C, Kukull, WA. The NACC Uniform Data Set. Alzheimers and Dementia, 6:S457, 2010. (Abstract)

356.   Bloudek L, Spackman E, Sullivan SD. A Comparison of Transitions between Health States and Institutionalization among AD Patients vs Non-AD Dementia Patients Using the NACC-UDS Database. Value Health, 13:A108-A109, 2010. (Abstract)

357.   Chen B, Zhou A. Marginal Method for Multi-level Incomplete Binary Data. Joint Statistical Meeting 2010, 2010. (Abstract)

358.   Cummings J, Lee C. Neuropathologic correlates of trial-related clinical assessments. Alzheimers and Dementia, 6:S142, 2010. (Abstract)

359.   De Santi, S, Pirraglia, E, Ferris, SH, Morris, JC, Weintraub, S and Johnson, N. Robust norms for the ADC UDS cognitive test battery. Alzheimers and Dementia, 6:S495-S496, 2010. (Abstract)

360.   Ebner LL, Appleby B. Neuropsychiatric Manifestations in Dementia: Difference Between Young Onset and Lat Onset Presentation. Alzheimers and Dementia, 6:S341, 2010. (Abstract)

361.   Farrer LA. US Alzheimer Disease Genetics Consortium: Organization and Results. Alzheimers and Dementia, 6:S67, 2010. (Abstract)

362.   Ganguli M, Kukull WA. Lost in translation: epidemiology, risk, and Alzheimer disease. Arch Neurol, 67:107-111, 2010, PMC2806646.

363.   Gill D, Koepsell T, Hubbard RA, Kukull, WA. Risk of 1-year Decline in Functional Activities in Dementia with Lewy Bodies and Alzheimer's Disease. Neurology, 74:A431, 2010. (Abstract)

364.   Hernandez S, McClendon MJ, Zhou XH, Sachs M, Lerner AJ. Pharmacological treatment of Alzheimer's disease: effect of race and demographic variables. J Alzheimers Dis, 19:665-672, 2010, PMC2827609.

365.   Jun G, Naj AC, Beecham GW, Wang LS, Buros J, Gallins PJ, Buxbaum JD, Ertekin-Taner N, Fallin MD, Friedland R, Inzelberg R, Kramer P, Rogaeva E, St George-Hyslop P, Cantwell LB, Dombroski BA, Saykin AJ, Reiman EM, Bennett DA, Morris JC, Lunetta KL, Martin ER, Montine TJ, Goate AM, Blacker D, Tsuang DW, Beekly D, Cupples LA, Hakonarson H, Kukull W, Foroud TM, Haines J, Mayeux R, Farrer LA, Pericak-Vance MA, Schellenberg GD. Meta-analysis confirms CR1, CLU, and PICALM as alzheimer disease risk loci and reveals interactions with APOE genotypes. Arch Neurol, 67:1473-1484, 2010, PMC3048805.

366.   Kaur B, Harvey D, DeCarli C, Sabbagh M, Olichney J. Comparison of extrapyramidal signs (EPS) to dementia severity in Alzheimer's disease (AD) and Dementia with Lewy Bodies (DLB). Alzheimers and Dementia, 6:P2-174, 2010. (Abstract)

367.   Kielb SA, Okonkwo OC, Sur S, Kortte KB, Onyike CU. Education, Executive Functions and the Trajectory of Disability in Frontotemporal Dementia. Int'l Conference for Frontotemporal Dementia, 2010. (Abstract)

368.   Knopman D, Weintraub S, Pankratz VS. Language and Behavior Domain Enhance the Value of the Clinical Dementia Rating Scale. Neurology, 74:A429-A430, 2010. (Abstract)

369.   Koepsell T, Gill D, Chen B. Stability of Dementia Diagnosis in the National Alzheimer's Coordinating Center (NACC) Uniform Data Set. Alzheimers and Dementia, 6:S365, 2010. (Abstract)

370.   Lau DT, Mercaldo ND, Harris AT, Trittschuh E, Shega J and Weintraub S. Polypharmacy and potentially inappropriate medication use among community-dwelling elders with dementia. Alzheimer Dis Assoc Disord, 24:56-63, 2010, PMC2837122.

371.   Middleton LE, Grinberg L, Kawas CH, Miller B, Yaffe K. The Nueropathological Features Associated with Alzheimer's Disease Diagnosis in The Oldest Old Versus the Young Old. Alzheimers and Dementia, 6:S108-S109, 2010. (Abstract)

372.   Nelson PT, Jicha GA, Kryscio RJ, Abner EL, Schmitt FA, Cooper G, Xu LO, Smith CD, Markesbery WR. Low sensitivity in clinical diagnoses of dementia with Lewy bodies. J Neurol, 257:359-366, 2010, PMC2839040.

373.   Nelson PT, Kukull WA, Frosch MP. Thinking outside the box: Alzheimer-type neuropathology that does not map directly onto current consensus recommendations. J Neuropathol Exp Neurol, 69:449-454, 2010, PMC2892786.

374.   Nelson PT, Schmitt FA, Jicha GA, Kryscio RJ, Abner EL, Smith CD, Van Eldik LJ, Markesbery WR. Association between male gender and cortical Lewy body pathology in large autopsy series. J Neurol, 257:1875-1881, 2010, PMC3040648.

375.   O'Bryant SE, Lacritz LH, Hall J, Waring SC, Chan W, Khodr ZG, Massman PJ, Hobson V, Cullum CM. Validation of the new interpretive guidelines for the clinical dementia rating scale sum of boxes score in the national Alzheimer's coordinating center database. Arch Neurol, 67:746-749, 2010, PMC2888493.

376.   Petersen RC, Gill DP, Phillips LE, Aisen P. Early MCI as an Imaging Target: data from the National Alzheimer's Coordinating Center. Alzheimers and Dementia, 6:S58, 2010. (Abstract)

377.   Phillips L, Roe CM, Gill D, Koepsell TD, Morris JC. Family History, Demographics, and Genetic Characteristics of Symptomatic and Non-Symptomatic Subjects with Neuropathological Alzheimer's Disease in the National Alzheimer's Coordinating Center (NACC). Alzheimers and Dementia, 6:S126, 2010. (Abstract)

378.   Rosenberg PB, Lyketsos CG. A New Concept: The Concept of Mild Behavioral Impairment (MBI). Emotions Et Cognition Dans Les Maladies Neurologiques, Marseille France, 2010. (Abstract)

379.   Sachs M. Factors Associated with Brain Autopsy in a Large Sample of Decedents. Alzheimers and Dementia, 6:S460-S461, 2010. (Abstract)

380.   Sayed N, Diaz-Arrastia R. Clinical Phenotype of Dementia after Traumatic Brain Injury (TBI). Neurology, 74:A139, 2010. (Abstract)

381.   Steenland K, Macneil J, Bartell S, Lah J. Analyses of diagnostic patterns at 30 Alzheimer's disease centers in the US. Neuroepidemiology, 35:19-27, 2010, PMC2919431.

382.   Tartaglia MC, Mehta KM, Hu B, Miller BL, Boxer AL. Medication Use Differs in Alzheimer's disease and Frontotemporal dementia. Alzheimers and Dementia, 6:S589-S590, 2010. (Abstract)

383.   Teng E, Becker BW, Woo E, Cummings JL, Lu PH. Subtle Deficits in Instrumental Activities of Daily Living in Subtypes of Mild Cognitive Impairment. Dement Geriatr Cogn Disord, 30:189-197, 2010, PMC2948658.

384.   Teng E, Becker BW, Woo E, Knopman DS, Cummings JL, Lu PH. Utility of the Functional Activities Questionnaire for Distinguishing Mild Cognitive Impairment From Very Mild Alzheimer Disease. Alzheimer Dis Assoc Disord, 24:348-353, 2010, PMC2997338.

385.   Walters GD. Dementia: Continuum or distinct entity?. Psychol Aging, 25:534-544, 2010, PMC2943994.

386.   Yamout K. AD Pathology, Vascular Neuropathology and Cognition. Intl Neuropsychology Society Meeting, 2010. (Abstract)

 
         2009
387.   Acevedo A, Krueger KR, Navarro E, Ortiz F, Manly JJ, Padilla-Velez MM, Weintraub S, Lopez OL, Mungas D. The Spanish translation and adaptation of the Uniform Data Set of the National Institute on Aging Alzheimer's Disease Centers. Alzheimer Dis Assoc Disord, 23:102-109, 2009, PMC2963171.

388.   Gill DP, Koepsell TD, Kukull WA. Risk of Decline in Functional Activities in Dementia with Lewy Bodies and Alzheimer's Disease. Neuroepidemiology, 33:71, 2009. (Abstract)

389.   Hsieh HN, Su HY, Zhou XH. Interval estimation for the difference in paired areas under the ROC curves in the absence of a gold standard test. Stat Med, 28:3108-3123, 2009, PMC2812057.

390.   Kukull WA, Phillips L, Gill D, Wu J, Sachs M, Beekly D, Koepsell T. Primary Neuropathologic Diagnosis and Co-Occurrence of Other Neuropathologic Features: Results from the National Alzheimer's Coordinating Center (NACC). Alzheimers and Dementia, 5:P71-P72, 2009. (Abstract)

391.   Kukull WA. Commentary on a roadmap for the prevention of dementia II: Leon Thal Symposium 2008 "Big Asks": what can be changed to increase and speed progress on Alzheimer's disease research and treatment?". Alzheimer's and Dementia, 5:137-139, 2009, PMC3744190.

392.   Lau DT, Mercaldo ND, Rademakers R, Shega J, Weintraub S. Cognitive, functional, and behavioral decline associated with polypharmacy and potentially inappropriate medication use in community-dwelling elders with and without dementia. American Public Health Association, 137th Annual Conference Philadelphia, PA, 2009. (Abstract)

393.   Longstreth WT, Sonnen JA, Koepsell TD, Kukull WA, Larson EB and Montine TJ. Associations between microinfarcts and other macroscopic vascular findings on neuropathologic examination in 2 databases. Alzheimer Dis Assoc Disord, 23:291-294, 2009, PMC2919361.

394.   McClendon MJ, Hernandez S, Smyth KA, Lerner AJ. Memantine and acetylcholinesterase inhibitor treatment in cases of CDR 05 or questionable impairment. J Alzheimers Dis, 16:577-583, 2009, PMC2827605.

395.   Nelson PT, Abner EL, Schmitt FA, Kryscio RJ, Jicha GA, Santacruz K, Smith CD, Patel E, Markesbery WR. Brains With Medial Temporal Lobe Neurofibrillary Tangles But No Neuritic Amyloid Plaques Are a Diagnostic Dilemma But May Have Pathogenetic Aspects Distinct From Alzheimer Disease. J Neuropathol Exp Neurol, 68:774-784, 2009, PMC2725359.

396.   Nelson PT, Kryscio RJ, Jicha GA, Abner EL, Schmitt FA, Xu LO, Cooper G, Smith CD, Markesbery WR. Relative preservation of MMSE scores in autopsy-proven dementia with Lewy bodies. Neurology, 73:1127-1133, 2009, PMC2764396.

397.   Phillips LE, Koepsell TD and Kukull WA. Refusal and Passive Loss-to-Follow-up in the NIA Alzheimer's Disease Program Uniform Data Set. Neurology, 72:A479-A480, 2009. (Abstract)

398.   Spackman DE. Measuring Progression in Alzheimer's Disease: 'Dependence' as a Health Outcome and Transition Probabilities Between Stages of Disease, Institutionalization and Death. Doctoral Dissertation, University of Washington, R01 AG027224, 2009.

399.   Webster JA, Gibbs JR, Clarke J, Ray M, Zhang W, Holmans P, Rohrer K, Zhao A, Marlowe L, Kaleem M, McCorquodale DS, 3rd, Cuello C, Leung D, Bryden L, Nath P, Zismann VL, Joshipura K, Huentelman MJ, Hu-Lince D, Coon KD, Craig DW, Pearson JV, Heward CB, Reiman EM, Stephan D, Hardy J, Myers AJ. Genetic control of human brain transcript expression in Alzheimer disease. Am J Hum Genet, 84:445-458, 2009, PMC2667989.

400.   Weintraub S, Salmon D, Mercaldo N, Ferris S, Graff-Radford NR, Chui H, Cummings J, DeCarli C, Foster NL, Galasko D, Peskind E, Dietrich W, Beekly DL, Kukull WA, Morris JC. The Alzheimer's Disease Centers' Uniform Data Set (UDS): the neuropsychologic test battery. Alzheimer Dis Assoc Disord, 23:91-101, 2009, PMC2743984.

 
         2008
401.   Becker B, Lu P, Woo E, Kim M, Cummings J. Insight into memory and mood functioning in amnestic mild cognitive impairment. 133rd Annual Meeting of the American Neurological Association, Salt Lake City, UT, 2008. (Abstract)

402.   Chi YY, Zhou XH. Receiver operating characteristic surfaces in the presence of verification bias. Appl Stat, 57:1-23, 2008.

403.   Hong MG, Myers AJ, Magnusson PK, Prince JA. Transcriptome-wide assessment of human brain and lymphocyte senescence. PLoS ONE, 3:e3024, 2008, PMC2515343.

404.   Hubbard R, Zhou XH. A non-homogeneous Markov process model for Alzheimer's disease progression. Int Biometrics Society, 159, 2008. (Abstract)

405.   Hubbard RA, Zhou A. Modeling Risk Factors for Alzheimer's Disease Progression Using a Nonhomogeneous Markov Process. Joint Statistical Meeting, 193, 2008. (Abstract)

406.   Hubbard R. Identifying risk factors for conversion between normal cognition, MCI, and dementia using Markov processes. Alzheimers and Dementia, 4:T675-676, 2008. (Abstract)

407.   Ishihara-Paul L, Viswanathan A, Allen J, Hyman B, Betensky R, Weil J, Blacker D, Irizarry M. P30 use of an US claims database and an US Alzheimer's Disease registry to assess clinical trial eligibility criteria. Health and Aging, 12:543, 2008. (Abstract)

408.   Koepsell TD, Kurland BF, Harel O, Johnson EA, Zhou XH, Kukull WA. Education, cognitive function, and severity of neuropathology in Alzheimer disease. Neurology, 70:1732-1739, 2008.

409.   Maddox RA, Mercaldo ND, Deitrich WD, Holman RC, Gambetti P, Harvey AR, Schonberger LB, Kukull WA Belay ED. Clinically unrecognized cases of prion disease in the National Alzheimer's Coordinating Center Database. Prion 2008 conference Madrid Spain, 2008. (Abstract)

410.   Mercaldo N, Harris AT, Weintraub S, Lau DT. Potentially Inappropriate Medication Use Among Community-Dwelling Elderly Patients With Dementia In US Alzheimer's Disease Centers. 136th Annual Conference, Gerontological Health Section, 2008. (Abstract)

411.   Sachs M, Koepsell TD. Factors Associated with Brain Autopsy in a Large Multi-Center Sample of Decedents: A Multivariate Analysis. Alzheimers and Dementia, 4:T712, 2008. (Abstract)

412.   Steenland K, Macneil J, Lah J. Analyses of diagnostic patterns at 30 Alzheimer Disease Research Centers in the US. 10th Int'l Symposium on Neurobehavioral Methods and Effects in Environmental and Occupational Health (NEUREOH), San Jose, Costa Rica, 2008. (Abstract)

413.   Teng E, Becker B, Woo E, Knopman D, Cummings H, Mendez M, Lu P. Utility of the functional activities questionnaire for distinguishing mild cognitive impairment from mild Alzheimer's disease. J Int Neuropsychol Soc, 14:259, 2008. (Abstract)

414.   Teng E, Becker B, Woo E, Yau A, Cummings J, Mendez M, Lu P. Instrumental activities of daily living in subtypes of mild cognitive impairment. J Int Neuropsychol Soc, 13:259-260, 2008. (Abstract)

415.   Webster JA, Myers AJ, Pearson JV, Craig DW, Hu-Lince D, Coon KD, Zismann VL, Beach T, Leung D, Bryden L, Halperin RF, Marlowe L, Kaleem M, Huentelman MJ, Joshipura K, Walker D, Heward CB, Ravid R, Rogers J, Papassotiropoulos A, Hardy J, Reiman EM, Stephan DA. Sorl1 as an Alzheimer's disease predisposition gene?. Neurodegener Dis, 5:60-64, 2008.

416.   Weintraub S, Mercaldo N, Harris A, Lau D. Polypharmacy among Community-Dwelling Elderly Patients with Dementia: Analysis of the National Alzheimer's Coordinating Center Uniform Data Set. Alzheimers and Dementia, 4:T454, 2008. (Abstract)

 
         2007
417.   Beekly DL, Ramos EM, Lee WW, Deitrich WD, Jacka ME, Wu J, Hubbard JL, Koepsell TD, Morris JC, Kukull WA. The National Alzheimer's Coordinating Center (NACC) database: the Uniform Data Set. Alzheimer Dis Assoc Disord, 21:249-258, 2007.

418.   Deitrich W, Beekly D, Lee W, Koepsell T, Kukull W. Web-based Data Quality Assurance Reports at the National Alzheimer's Coordinating Center (NACC). Proceedings of the SAS® Global Forum 2007 Conference; 2007; Cary, NC: SAS Institute Inc, 2007.

419.   Harel O, Zhou XH. Multiple imputation for the comparison of two screening tests in two-phase Alzheimer studies. Stat Med, 26:2370-2388, 2007.

420.   Harel O, Zhou XH. Multiple imputation: review of theory, implementation and software. Stat Med, 26:3057-3077, 2007.

421.   Koepsell TD, Chi YY, Zhou XH, Lee WW, Ramos EM, Kukull WA. An alternative method for estimating efficacy of the AN1792 vaccine for Alzheimer disease. Neurology, 69:1868-1872, 2007.

422.   Koepsell TD, Chi YY, Zhou XH, Lee WW, Ramos EM, Kukull W. An alternative method for estimating efficacy of the AN1792 vaccine for Alzheimer's disease. Neurology, 68:A169-A170, 2007. (Abstract)

423.   Myers AJ, Gibbs JR, Webster JA, Rohrer K, Zhao A, Marlowe L, Kaleem M, Leung D, Bryden L, Nath P, Zismann VL, Joshipura K, Huentelman MJ, Hu-Lince D, Coon KD, Craig DW, Pearson JV, Holmans P, Heward CB, Reiman EM, Stephan D, Hardy J. A survey of genetic human cortical gene expression. Nat Genet, 39:1494-1499, 2007.

424.   Weiner MF, Hynan LS, Beekly D, Koepsell TD, Kukull WA. Comparison of Alzheimer's Disease in American Indians, Whites, and African Americans. Alzheimers and Dementia, 3:211-216, 2007.

 
         2006
425.   Beekly DL, Ramos EM, Jacka ME, Deitrich WD, Hubbard JD, Wu J, Lee WW, Morris JC, Kukull WA. The National Alzheimer's Coordinating Center's Data Submissions System and Database. Alzheimers and Dementia, 2:S267, 2006. (Abstract)

426.   Harel O, Zhou XH. Multiple imputation for correcting verification bias. Stat Med, 25:3769-3786, 2006.

427.   Kukull WA, Dickson DW, Montine TJ, Ramos EM, Zhang A, Koepsell TD. Lewy body (LB) pathology and clinical diagnoses in the National Alzheimer's Coordinating Center (NACC) database. Alzheimer's and Dementia, 2:S430-431, 2006. (Abstract)

428.   Kukull WA. The growing global burden of dementia. Lancet Neurol, 5:199-200, 2006.

429.   Lee WW, Beekly DL, Ramos EM, Jacka ME, Deitrich WD, Hubbard JL, Wu J, Morris JS and Kukull WA. Using the web to collect data for Alzheimer's research. 11th World Congress on Internet & Medicine, 2006. (Abstract)

430.   Morris JC, Weintraub S, Chui HC, Cummings J, Decarli C, Ferris S, Foster NL, Galasko D, Graff-Radford N, Peskind ER, Beekly D, Ramos EM, Kukull WA. The Uniform Data Set (UDS): clinical and cognitive variables and descriptive data from Alzheimer Disease Centers. Alzheimer Dis Assoc Disord, 20:210-216, 2006.

431.   Morris JC. Uniform Data Set (UDS). Alzheimer's and Dementia, 2:S261-S262, 2006. (Abstract)

432.   Noda A, Kraemer HC, Taylor JL, Schneider B, Ashford JW, Yesavage JA. Strategies to reduce site differences in multisite studies: a case study of Alzheimer disease progression. Am J Geriatr Psychiatry, 14:931-938, 2006.

433.   Zhang Z, Ramos E, Zhou A, Koepsell T, Kukull WA. Agreement between neuropathologic criteria for the diagnosis of Alzheimer's disease. Neurology, 66:283, 2006. (Abstract)

 
         2005
434.   Chow TW, Hodges JR, Dawson KE, Miller BL, Smith V, Mendez MF, Lipton AM. Referral patterns for syndromes associated with frontotemporal lobar degeneration. Alzheimer Dis Assoc Disord, 19:17-19, 2005, PMC1578638.

435.   Harel O, Koepsell T, Kukull WA, Zhou XH. Correcting for verification bias in the assessment of the accuracy of the clinical diagnosis of AD. Neurology, 64:A69, 2005. (Abstract)

436.   Honig LS, Kukull W, Mayeux R. Atherosclerosis and AD: analysis of data from the US National Alzheimer's Coordinating Center. Neurology, 64:494-500, 2005.

437.   Koepsell T, Kurland BF, Zhou XH, Harel O, Kukull WA. Education, cognitive function, and severity of neuropathology in Alzheimer's disease. 7th Intl Conference AD/PD Book of Abstracts, 67, 2005. (Abstract)

438.   Kurland BF, Kukull WA, Koepsell TD, Zhou XH, Ramos EP, Harel O. Impact of time scale choice on rate of cognitive decline: a case study from the National Alzheimer's Coordinating Center Minimum Data Set. Alzheimers and Dementia, 1:S33-34, 2005. (Abstract)

439.   Kurland BF, Heagerty PJ. Directly parameterized regression conditioning on being alive: analysis of longitudinal data truncated by deaths. Biostatistics, 6:241-258, 2005.

440.   Ramos EM, Koepsell TD, Kurland BF, Harel O, Zhou XH, Kukull WA. Pathology of subjects clinically diagnosed with vascular dementia. Vas Cog 2005 Abstract Book, 22, 2005. (Abstract)

 
         2004
441.   Beekly DL, Ramos EM, van Belle G, Deitrich W, Clark AD, Jacka ME, Kukull WA. The National Alzheimer's Coordinating Center (NACC) Database: an Alzheimer disease database. Alzheimer Dis Assoc Disord, 18:270-277, 2004.

442.   Fitzpatrick AL, Kukull WA, Koepsell T, Higdon R. Survival by Type of Dementia: Data from the National Alzheimer's Coordinating Center. Neurology, 62:A452, 2004. (Abstract)

443.   Fitzpatrick AL, Kukull WA, Koepsell TD, Higdon R, Pfeiffer E, Kurland B. Depression within dementia subtypes: data from the National Alzheimer's Coordinating Center. Neurobiol, 25:479, 2004. (Abstract)

444.   Higdon R, Foster NL, Koeppe RA, DeCarli CS, Jagust WJ, Clark CM, Barbas NR, Arnold SE, Turner RS, Heidebrink JL, Minoshima S. A comparison of classification methods for differentiating fronto-temporal dementia from Alzheimer's disease using FDG-PET imaging. Stat Med, 23:315-326, 2004.

445.   Koepsell TD, Kukull WA, Beekly D, van Belle G, Higdon R, Fitzpatrick A, Kurland B. Public-use data from NACC. Neurobiol Aging, 25:386, 2004. (Abstract)

446.   Kukull WA. Perspectives on shared genetic contributions for Parkinson disease and Alzheimer disease. Arch Neurol, 61:1007-1008, 2004.

447.   Kurland BF, Heagerty PJ. Marginalized transition models for longitudinal binary data with ignorable and non-ignorable drop-out. Stat Med, 23:2673-2695, 2004.

448.   Pfeiffer EM, Higdon R, Koepsell TD, Fitzpatrick AL, Beekly DL, Kukull WA. Examining the agreement between CERAD and NIA/Regan Institute neuropathological criteria for the diagnosis of Alzheimer's disease. Neurobiol Aging, 25:134, 2004. (Abstract)

 
         2003
449.   Higdon R, Beekly D, Pfeiffer EA, van Belle G, Kukull WA. Sensitivity and specificity of Alzheimer's disease and dementia diagnoses for patients enrolled in NIA funded Alzheimer's Disease Centers. Neurology, 60:A309-A310, 2003. (Abstract)

450.   Kurland BF, Heagerty PJ. Targets of inference for longitudinal data censored by dropout and death. In: 2003 Proceedings of the American Statistical Association, Biometrics Section CD-ROM, 2003.

 
         2002
451.   Kukull WA, Higdon R, Bowen JD, McCormick WC, Teri L, Schellenberg GD, van Belle G, Jolley L, Larson EB. Dementia and Alzheimer disease incidence: a prospective cohort study. Arch Neurol, 59:1737-1746, 2002.

452.   Kukull WA, Bowen JD. Dementia epidemiology. Med Clin North Am, 86:573-590, 2002.

 
         2001
453.   Kukull WA. The association between smoking and Alzheimer's disease: effects of study design and bias. Biol Psychiatry, 49:194-199, 2001.

 
         2000
454.   Kukull WA, Ganguli M. Epidemiology of dementia: concepts and overview. Neurol Clin, 18:923-950, 2000.

 
       Externally-Funded Awards
         2015
455.   Curry TE. Building Interdisciplinary Research Careers in Women's Health. NIH/NIDA, 5K12DA035150, 01/01/2015.

 
         2014
456.   Crane P. Genetic architecture of memory and executive functioning in Alzheimer's disease. NIH, R01 AG042437, 09/01/2014.

457.   Millikin C. Neuroimaging correlates of delusions in Alzheimer's Disease and related dementias. CIHR, CSE313912, 02/02/2014.

 
         2013
458.   Nelson P. Sexually Dimorphic Mir-497 Regulates Alpha-Synuclein And Alpha-Synucleinopathy. NIH/NINDS, R21 NS085830, 09/25/2013.

 
         2012
459.   Zhang J. Large Scale Biomarker Discovery and Validation for Parkinson's Disease. NIH/NINDS, U01 NS082137, 09/30/2012.

 
         2011
460.   Gill DP. Predicting the Rate of Functional Decline in Alzheimer's Disease, Vascular Dementia, and Dementia with Lewy Bodies. CIHR, LAF-95193, 01/04/2011.

461.   Kukull W, Koepsell T, Gill DP. Functional Decline in Three Demenia Types. NIH/NIA, R03 AG035027, 09/01/2011.

462.   Kukull W, Morris J. LP Survey. Alzheimer Association, LPS-11-219245, 09/01/2011.

 

NACC-Funded Junior Investigator Awards for Secondary Data Analyses: (TOTAL of 42)

   Principal Investigator: Yorghos Tripodis, PhD (NACC Project #2013-JI-02)
   Title: Predicting the Cognitive Status of an Aging Population
   Lead Institutions: Boston University
 
       Publications
1.   Tripodis Y, Zirogiannis N. Predicting the cognitive status of an aging population. Alzheimers and Dementia, 10:P722, 2014. (Abstract)

2.   Tripodis Y, Zirogiannisz N. Dynamic Factor Analysis for Cognitive Trajectories. Stat Med, submitted 2014.


   Principal Investigator: Brittany Dugger, PhD (NACC Project #2013-JI-03)
   Title: Relationship of Cardiovascular Risk Factors to Dementia Subtypes
   Lead Institutions: Arizona ADC
 
       Publications
3.   Dugger BN, Hentz JG, Adler CH, Sabbagh MN, Shill HA, Jacobson S, Caviness JN, Belden C, Driver-Dunckley E, Davis KJ, Sue LI, Beach TG, Consortium atAPD. Neuropathological Outcome of Prospectively Followed Normal Elderly Brain Bank Volunteers. Alzheimers and Dementia, 9:P336, 2013. (Abstract)

4.   Dugger BN, Hentz JG, Adler CH, Sabbagh MN, Shill HA, Jacobson S, Caviness JN, Belden C, Driver-Dunckley E, Davis KJ, Sue LI, Beach TG. Clinicopathological outcomes of prospectively followed normal elderly brain bank volunteers. J Neuropathol Exp Neurol, 73:244-252, 2014, PMC4066814.

5.   Dugger BN, Malek-Ahmadi M, Monsell S, Kukull W, Woodruff B, Reiman E, Beach TG, Wilson J. Cardiovascular Risk Factors and Their Interactions Among Clinically Defined Neurodegenerative Diseases. Alzheimers and Dementia, 10:P151-152, 2014. (Abstract)

6.   Dugger BN, Malek-Ahmadi M, Monsell SE, Kukull WA, Woodruff BK, Reiman EM, Beach TG, Wilson J. Late life cardiovascular factors in clinically defined neurodegenerative diseases. Alzheimers and Dementia, submitted 2014.


   Principal Investigator: Maritza Dowling MS, PhD (NACC Project #2012-JI-04)
   Title: Missing Data and the Identification of Optimal Predictors of Conversion to AD
   Lead Institutions: University of Wisconsin
 
       Publications
7.   Dowling NM. Missing Data and the Identification of Optimal Predictors of Conversion to AD. Alzheimers and Dementia, 9:P776-777, 2013. (Abstract)


   Principal Investigator: Joshua Grill (NACC Project #2012-JI-09)
   Title: Assessing Disease Progression Among Alzheimer's Disease Patients With Adult Child Study Partners
   Lead Institutions: University of California, Los Angeles
 
       Publications
8.   Grill JD, Zhou Y, Karlawish J, Elashoff D. Does study partner type impact the rate of Alzheimer's disease progression. J Nutr Health Aging, 17:816, 2013. (Abstract)

9.   Grill JD, Zhou Y, Karlawish J, Elashoff D. Does study partner type impact the rate of Alzheimer's disease progression?. J Alzheimers Dis, 38:507-514, 2014, PMC3842422.

10.   Grill JD, Zhou Y, Karlawish J, Elashoff D. Frequency and Impact of Informant Replacement in Alzheimer Disease Research. Alzheimers Disease Associated Disorders, in press 2014, NIHMS644849.

11.   Grill JD, Zhou Y, Karlawish J, Elashoff D. The impact of study partner change in Alzheimer's disease research. Alzheimers and Dementia, 10:P852, 2014. (Abstract)


   Principal Investigator: Katherine Gifford PhD (NACC Project #2011-JI-08)
   Title: Subjective Memory Complaint and Cognitive Aging
   Lead Institutions: Boston University
 
       Publications
12.   Gifford KA, Carmona H, Tripodis Y, Martin B, Cantwell N, Kowall N, Jefferson AL. Subjective Cognitive Complaint Predicts Cognitive and Functional Trajectory in Individuals with Mild Cognitive Impairment. Int'l Neuropsychological Society Meeting, 2012. (Abstract)

13.   Gifford KA, Liu D, Lu Z, Carmona H, Romano R, Tripodis Y, Martin B, Kowall N, Jefferson AL. Inclusion of an informant yields strong associations between cognitive complaint and longitudinal cognitive outcomes in non-demented elders. J Alzheimers Dis, 43:121-132, 2015, PMC4314962.

14.   Gifford KA, Liu D, Lu Z, Tripodis Y, Cantwell N, Palmisano J, Kowall N, Jefferson AL. The source of cognitive complaints predicts diagnostic conversion differentially among nondemented older adults. Alzheimers and Dementia, 10:319-327, 2014, PMC4064681.

15.   Tripodis Y, Palmisano J, Gentile A, Jefferson A. Subjective Complaint and Cognitive Aging. Alzheimers and Dementia, 7:S545, 2011. (Abstract)


   Principal Investigator: Patrick Brown PhD (NACC Project #2010-JI-01)
   Title: Common Functional Deficits in MCI and Dementia
   Lead Institutions: Columbia University
 
       Publications
16.   Brown PJ, Liu X, Sneed JR, Pimontel MA, Devanand DP, Roose SP. Speed of processing and depression affect function in older adults with mild cognitive impairment. Am J Geriatric Psychiatry, 21:675-684, 2013, PMC3410965.

17.   Brown PJ, Sneed JR, Rutherford B, Devanand DP, Roose SP. The nuances of cognition and depression in older adults: the need for a comprehensive assessment. Intl J Geriatric Psychiatry, 29:506-514, 2014, PMC3975802.

18.   Devanand DP, Liu X, Brown P. Functional deficits in the transition from mild cognitive impairment to dementia. JAMA, submitted 2014.


   Principal Investigator: Berneet Kaur, MD (NACC Project #2010-JI-05)
   Title: The Influence of Smoking History on the Phenotype and Pathology of Dementia
   Lead Institutions: University of California, Davis
 
       Publications
19.   Kaur B, Harvey D, Tong E, Hofstetter CR, DeCarli C, Olichney J. A Comparison of Extrapyramidal Signs Between Smokers and Nonsmokers with Dementia. Neurology, 80:P07.153, 2013. (Abstract)

20.   Kaur B, Harvey D, Tong E, Hofstetter CR, DeCarli C, Olichney J. The relationship of smoking history and vascular risk factors to motor parkinsonism in dementia. Neurology, 78(1):P04202, 2012. (Abstract)


   Principal Investigator: Kathleen Hayden PhD (NACC Project #2008-JI-02)
   Title: Identification of Cognitive Endophenotypes
   Lead Institutions: Duke University
 
       Publications
21.   Hayden KM, Jones RN, Zimmer C, Plassman B, Browndyke JN, Pieper C, Warren LH, Welsh-Bohmer KA. Factor Structure of the National Alzheimer's Coordinating Centers Uniform Dataset Neuropsychological Battery: An evaluation of invariance between and within groups over time. Alzheimer Dis Assoc Disord, 25:128-137, 2011, PMC3101374.

22.   Hayden KM, Kuchibhatla M, Plassman BL, Romero HR, Burke JR, Welsh-Bohmer KA. Pre-clinical cognitive phenotypes for Alzheimer's disease: a latent profile approach. Alzheimers and Dementia, 8:P363, 2012. (Abstract)

23.   Hayden KM, Kuchibhatla M, Romero HR, Plassman BL, Burke JR, Browndyke JN, Welsh-Bohmer KA. Pre-clinical Cognitive Phenotypes for Alzheimer Disease: A Latent Profile Approach. Am J Geriatr Psychiatry, in press 2013, PMC3968245.

24.   Hayden KM, Warren LH, Plassman B, Browndyke J, Pieper C, Sanders L, Welsh-Bohmer KA. Neuropsychological Domains in Mild Cognitive Impairment and Normal Aging: Results from the NACC UDS Study. Alzheimers and Dementia, 5:P448, 2009. (Abstract)


   Principal Investigator: Ann Mayo, RN DNSc (NACC Project #2007-JI-01)
   Title: Determinants of Judgment and Problem Solving Among Patients with Dementia
   Lead Institutions: UC, San Francisco
 
       Publications
25.   Mayo AM, Wallhagen M, Cooper BA, Mehta K, Ross L, Miller B. The relationship between functional status and judgment/problem solving among individuals with dementia. Int J Geriatr Psychiatry, 28:514-521, 2013, PMC3496819.

26.   Mayo, AM, Wallhagen, M, Cooper, BA, Mehta, K, Ross, L and Miller, B. Determinants of Judgment and Problem Solving in Persons with Dementia. American Geriatrics Society Annual Meeting in Chicago on April 30, 2009, 2009. (Abstract)


   Principal Investigator: Liana Apostolova, MD (NACC Project #2007-JI-02)
   Title: Behavioral Reserve in MCI and AD
   Lead Institutions: University of California, Los Angeles
 
       Publications
27.   Apostolova L, Tseng C, Fairbanks L, Elashoff D, Cummings J. Effect of age, gender, marital status and education on behavioral symptoms in MCI and mild AD subjects. Neurology, 74:A21, 2010. (Abstract)

28.   Apostolova LG, Di LJ, Duffy EL, Brook J, Elashoff D, Tseng CH, Fairbanks L, Cummings JL. Risk factors for behavioral abnormalities in mild cognitive impairment and mild Alzheimer's disease. Dement Geriatr Cogn Disord, 37:315-326, 2014, PMC4057985.

29.   Apostolova LG, Di LJ, Tseng CH, Fairbanks L, Elashoff D, Cummings JL. Behavioral reserve in mild cognitive impairment and mild Alzheimer's disease. Alzheimers and Dementia, 8:P323, 2012. (Abstract)

30.   Apostolova LG, Di LJ, Tseng CH, Fairbanks L, Elashoff D, Cummings JL. Comparison of the prevalence of neuropsychiatric behaviors between amnestic and nonamnestic MCI subjects. Alzheimers and Dementia, 8:P135, 2012. (Abstract)


   Principal Investigator: Catherine Roe (NACC Project #2005-JI-03)
   Title: Education, the cognitive reserve hypothesis, and Alzheimer’s Disease Without Dementia
   Lead Institutions: Washington University
 
       Publications
31.   Roe CM, Xiong C, Grant E, Miller JP, Morris JC. Education and reported onset of symptoms among individuals with Alzheimer disease. Arch Neurol, 65:108-111, 2008, PMC2830808.

32.   Roe CM, Xiong C, Miller JP, Cairns NJ, Morris JC. Interaction of neuritic plaques and education predicts dementia. Alzheimer Dis Assoc Disord, 22:188-193, 2008, PMC2770714.

33.   Roe CM, Xiong C, Miller JP, Morris JC. Diffuse and Neuritic Plaques, Neurofibrillary Tangles, and APOE Genotype in Preclinical AD. Alzheimers and Dementia, 2:S247, 2006. (Abstract)

34.   Roe CM, Xiong C, Miller JP, Morris JC. Education and Alzheimer disease without dementia: support for the cognitive reserve hypothesis. Neurology, 68:223-228, 2007.

35.   Roe CM, Xiong C, Miller P, Morris JC. Education and Preclinical Alzheimer's Disease without Dementia. Alzheimer's and Dementia, 2:S146, 2006. (Abstract)

36.   Roe CM, Xiong CJ, Miller JP, Morris J. Education and Neuropathological Alzheimer s Disease, With and Without Dementia. Neurology, 66:A218, 2006. (Abstract)


   Principal Investigator: Michael Rapp A. (NACC Project #2005-JI-09)
   Title: Neuropathological Changes in Dementia in Patients with Co-morbid Depression
   Lead Institutions: Mount Sinai School of Medicine
 
       Publications
37.   Rapp MA, Haroutunina V, Sano M. Increased Plaques and Tangles in Alzheimer's Disease Patients with Co-morbid Depression. Society for Biological Psychiatry Annual Meeting, Toronto, Canada, 2006. (Abstract)

38.   Rapp MA, Schnaider-Beeri M, Purohit DP, Perl DP, Haroutunian V, Sano M. Increased neurofibrillary tangles in patients with Alzheimer disease with comorbid depression. Am J Geriatr Psychiatry, 16:168-174, 2008.


   Principal Investigator: Kala Mehta (NACC Project #2005-JI-11)
   Title: Ethnic Differences in Alzheimer’s Disease Survival and Pathology
   Lead Institutions: University of California, San Francisco
 
       Publications
39.   Mehta K, Kurland B, Barnes D, Yaffe K, Miller B, Perez-Stable EJ. African American and Latino AD Patients have longer survival than white AD patients: data from the National Alzheimer's Coordinating Center datasets. National Meeting of the Resource Center for Minority Aging Research, 2006. (Abstract)

40.   Mehta KM, Yaffe K, Perez-Stable EJ, Stewart A, Barnes D, Kurland BF, Miller BL. Race/ethnic differences in AD survival in US Alzheimer's Disease Centers. Neurology, 70:1163-1170, 2008, PMC2830859.

41.   Mehta KM, Kurland B, Barnes D, Yaffe K, Perez-Stable E, Miller B. African American and Latino Alzheimer's disease patient's have longer survival than white Alzheimer's disease patients: Data from the National Alzheimer's Coordinating Center datasets. Neurology, 66:A218, 2006. (Abstract)

42.   Ontaneda D, Mehta KM, Perez-Stable E. Race/ethnic differences in AD survival in us Alzheimer's disease centers. Neurology, 72:1620, 2009, PMC Journal - In Process.


NACC Funded Collaborative Projects (by project): (TOTAL of 187)

   Principal Investigator: Teresa Gomez-Isla MD, PhD (NACC Project #2011-03)
   Title: Are Some Human Brains Able to Resist Alzheimer's Pathology?
   Lead Institutions: Massachusetts ADRC
 
       Publications
1.   Barroeta-Espar I, Gómez Pérez-Nievas B, Meltzer A, Marquie M, García-Polite F, Moulder K, Morris JC, Parisi E, Petersen R, Ikonomovic M, López O, Vonsattel J, Mayeux R, Hyman BT, Gómez-Isla T. Accrual of oligomeric tau in synapses and glial reaction are more proximate correlates to cognition than plaques and tangles. 2014. (Abstract)

2.   Perez-Nievas BG, Stein TD, Tai HC, Dols-Icardo O, Scotton TC, Barroeta-Espar I, Fernandez-Carballo L, de Munain EL, Perez J, Marquie M, Serrano-Pozo A, Frosch MP, Lowe V, Parisi JE, Petersen RC, Ikonomovic MD, Lopez OL, Klunk W, Hyman BT, Gomez-Isla T. Dissecting phenotypic traits linked to human resilience to Alzheimer's pathology. Brain, 136:2510-2526, 2013, PMC3722351.

 
       Externally-Funded Awards
3.   Gomez-Isla MT. Dissecting molecular mechanisms involved in resilience to Alzheimer's pathology. NIH/NIA, R01 AG043511, 09/01/2013.


   Principal Investigator: Linda Boise, PhD, MPH (NACC Project #2010-05)
   Title: Ethnic Differences in Willingness to Assent to Brain Donation
   Lead Institutions: Oregon Health  Science U
 
       Publications
4.   Boise L, Hinton L, Rosen H, Ruhl M. Will my soul go to heaven if they take my brain? Beliefs and worries about brain donation among four ethnic groups. Gerontologist, submitted 2015.


   Principal Investigator: Brent Small (NACC Project #2008-01)
   Title: Changes in Cognitive performance in Preclinical AD: A Collaborative Analysis
   Lead Institutions: Florida ADC
 
       Publications
5.   Small BJ, Dixon RA, McArdle JJ. Tracking Cognition-Health Changes From 55 to 95 Years of Age. J Gerontol, 66:i153-161, 2011, PMC3132770.


   Principal Investigator: John H. Growdon, MD (NACC Project #2007-01)
   Title: Lewy Body Diseases Imaged with PiB
   Lead Institutions: Massachusetts ADRC
 
       Publications
6.   Gomperts SN, Johnson KA, Growdon J. Reply: Beyond the limits of detection: failure of PiB imaging to capture true Abeta burden. Movement Disorders, 28:407, 2013, PMC3741662.

7.   Gomperts SN, Locascio JJ, Marquie M, Santarlasci AL, Rentz DM, Maye J, Johnson KA, Growdon JH. Brain amyloid and cognition in Lewy body diseases. Movement Disorders, 27:965-973, 2012, PMC3725259.

8.   Growdon J, Gomperts S, Locascio J, Rentz D, Marquie Sayagues M, Santarlasci A, Johnson K. Brain Amyloid and Cognition in PD. 10th Int'l Conference on Alzheimer's and Parkinson's Disease; Barcelona, Spain, 2011. (Abstract)


   Co-Principal Investigator: Anne Fagan Niven & Alex Roher (NACC Project #2006-03,06)
   Title: Proteomic Analysis of Post-mortem and Ante-mortem Cerebrospinal Fluid for the Diagnosis of Alzheimer’s Disease
   Lead Institutions: WashU/Arizona ADC
 
       Publications
9.   Craig-Schapiro R, Perrin RJ, Roe CM, Grant EA, Carter D, Cairns NJ, Mintun MA, Peskind ER, Li G, Galasko DR, Clark CM, Quinn JF, D'Angelo G, Malone JP, Townsend R, Morris JC, Fagan AM, Holtzman DM. A Novel Diagnostic and Prognostic Fluid Biomarker for Early Alzheimer's Disease: YKL-40. Alzheimers and Dementia, 6:S506, 2010. (Abstract)

10.   Craig-Schapiro R, Perrin RJ, Roe CM, Xiong C, Carter D, Cairns NJ, Mintun MA, Peskind ER, Li G, Galasko DR, Clark CM, Quinn JF, D'Angelo G, Malone JP, Townsend RR, Morris JC, Fagan AM, Holtzman DM. YKL-40: a novel prognostic fluid biomarker for preclinical Alzheimer's disease. Biol Psychiatry, 68:903-912, 2010, PMC3011944.

11.   Maarouf CL, Andacht TM, Kokjohn TA, Castano EM, Sue LI, Beach TG, Roher AE. Proteomic analysis of Alzheimer's disease cerebrospinal fluid from neuropathologically diagnosed subjects. Curr Alzheimer Res, 6:399-406, 2009, PMC2832860.

12.   Perrin RJ, Craig-Schapiro R, Malone JP, Roe CM, Grant EA, Shah AR, Gilmore P, Davis AE, Peskind ER, Li G, Galasko DR, Quinn JF, Kaye JA, Clark CM, Morris JC, Holtzman DM, Townsend RR, Fagan AM. Identification and validation of novel cerebrospinal fluid protein biomarkers for early Alzheimer disease using proteomics and ELISA - a multi-institutional collaborative study. Alzheimers and Dementia, 6:S500, 2010. (Abstract)

13.   Perrin RJ, Craig-Schapiro R, Malone JP, Shah AR, Gilmore P, Davis AE, Roe CM, Peskind ER, Li G, Galasko DR, Clark CM, Quinn JF, Kaye JA, Morris JC, Holtzman DM, Townsend RR, Fagan AM. Identification and Validation of Novel Cerebrospinal Fluid Biomarkers for Staging Early Alzheimer's Disease. PLoS ONE, 6:e16032, 2011, PMC3020224.

14.   Perrin RJ, Malone JP, Shah AR, Craig-Schapiro R, Gilmore P, Davis AE, Peskind ER, Ge L, Galasko DR, Quinn JF, Kaye JA, Clark CM, Morris JC, Holtzman DM, Townsend RR, Fagan AM. Identification of potential biomarkers for Alzheimer's disease in cerebrospinal fluid using two-dimensional difference gel electrophoresis (2D-DIGE) and tandem mass spectrometry-a multi-institutional. Alzheimers and Dementia, 4:T543, 2008. (Abstract)

15.   Roher AE, Maarouf CL, Andacht TM, Kokjohn TA, Castano EM, Walker DG, Sabbagh MN, Beach TG. Proteomics-derived cerebrospinal fluid markers of autopsy-confirmed Alzheimer's disease. Alzheimers and Dementia, 6:S123, 2010. (Abstract)

16.   Roher AE, Maarouf CL, Sue LI, Hu Y, Wilson J, Beach TG. Proteomics-derived cerebrospinal fluid markers of autopsy-confirmed Alzheimer's disease. Biomarkers, 14:493-501, 2009, PMC2824250.


   Principal Investigator: Mony J. deLeon (NACC Project #2006-09)
   Title: Hippocampal Glucose Metabolism in Aging: Relationships to Cognitive Decline
   Lead Institutions: New York University School of Medicine
 
       Publications
17.   Mosconi L, Tsui WH, Herholz K, Pupi A, Drzezga A, Lucignani G, Reiman EM, Holthoff V, Kalbe E, Sorbi S, Diehl-Schmid J, Perneczky R, Clerici F, Caselli R, Beuthien-Baumann B, Kurz A, Minoshima S, de Leon MJ. Multicenter standardized 18F-FDG PET diagnosis of mild cognitive impairment, Alzheimer's disease, and other dementias. J Nucl Med, 49:390-398, 2008, PMC3703818.


   Principal Investigator: Sandra Weintraub (NACC Project #2005-05)
   Title: Clinical Phenotypes of FTD are Determined by Neuropathologic and Biochemical Features
   Lead Institutions: Northwestern University
 
       Publications
18.   Armstrong RA, Cairns NJ. Analysis of beta-amyloid (Abeta) deposition in the temporal lobe in Alzheimer's disease using Fourier (spectral) analysis. Neuropathol Appl Neurobiol, 36:248-257, 2010, PMC2972722.

19.   Armstrong RA, Ellis W, Hamilton RL, Mackenzie IR, Hedreen J, Gearing M, Montine T, Vonsattel JP, Head E, Lieberman AP, Cairns NJ. Neuropathological heterogeneity in frontotemporal lobar degeneration with TDP-43 proteinopathy: a quantitative study of 94 cases using principal components analysis. J Neural Transm, 117:227-239, 2010, PMC2830004.

20.   Cairns NJ, Bigio EH, Mackenzie IR, Neumann M, Lee VM, Hatanpaa KJ, White CL, 3rd, Schneider JA, Grinberg LT, Halliday G, Duyckaerts C, Lowe JS, Holm IE, Tolnay M, Okamoto K, Yokoo H, Murayama S, Woulfe J, Munoz DG, Dickson DW, Ince PG, Trojanowski JQ, Mann DM. Neuropathologic diagnostic and nosologic criteria for frontotemporal lobar degeneration: consensus of the Consortium for Frontotemporal Lobar Degeneration. Acta Neuropathol, 114:5-22, 2007, PMC2827877.

21.   Cairns NJ, Neumann M, Bigio EH, Holm IE, Troost D, Hatanpaa KJ, Foong C, White CL, 3rd, Schneider JA, Kretzschmar HA, Carter D, Taylor-Reinwald L, Paulsmeyer K, Strider J, Gitcho M, Goate AM, Morris JC, Mishra M, Kwong LK, Stieber A, Xu Y, Forman MS, Trojanowski JQ, Lee VM, Mackenzie IR. TDP-43 in familial and sporadic frontotemporal lobar degeneration with ubiquitin inclusions. Am J Pathol, 171:227-240, 2007, PMC1941578.

22.   Cairns NJ, Pang-Hsien T, Bigio EH, Schneider JA, White III CL, Hatanpaa K, Aggarwal NT, Womake KB, Schneider S, Grinberg LT, Morris JC, Wicklund AH, Weintraub S. Neuropathologic heterogeneity in frontotemporal lobar degeneration (FTLD) with ubiquitin inclusions: Report of the Midwest consortium for FTLD. Brain Pathology, 16:S5, 2006. (Abstract)

23.   Gitcho MA, Baloh RH, Chakraverty S, Mayo K, Norton JB, Levitch D, Hatanpaa KJ, White CL, 3rd, Bigio EH, Caselli R, Baker M, Al-Lozi MT, Morris JC, Pestronk A, Rademakers R, Goate AM, Cairns NJ. TDP-43 A315T mutation in familial motor neuron disease. Ann Neurol, 63:535-538, 2008, PMC2747362.

24.   Gitcho MA, Bigio EH, Mishra M, Johnson N, Weintraub S, Mesulam M, Rademakers R, Chakraverty S, Cruchaga C, Morris JC, Goate AM, Cairns NJ. TARDBP 3'-UTR variant in autopsy-confirmed frontotemporal lobar degeneration with TDP-43 proteinopathy. Acta Neuropathol, 118:633-645, 2009, PMC2783457.

25.   Hatanpaa KJ, Bigio EH, Cairns NJ, Schneider JA, Foong C, Hladik C, Shang P, White CL. TDP-43 immunohistochemistry reveals extensive neuritic pathology in FTLD-U: a Midwest-Southwest Consortium for FTLD study. J Neuropathol Exp Neurol, 66:425, 2007. (Abstract)

26.   Hatanpaa KJ, Bigio EH, Cairns NJ, Womack KB, Weintraub S, Morris JC, Foong C, Xiao G, Hladik C, Mantanona TY, White III CL. TAR DNA-binding protein 43 immunohistochemistry reveals extensive neuritic pathology in FTLD-U: a midwest-southwest consortium for FTLD study. J Neuropathol Exp Neurol, 67:271-279, 2008, PMC2635119.

27.   Liscic RM, Grinberg LT, Zidar J, Gitcho MA, Cairns NJ. ALS and FTLD: two faces of TDP-43 proteinopathy. Eur J Neurol, 15:772-780, 2008, PMC2801606.


   Principal Investigator: Debby Tsuang, MD (NACC Project #2003-03)
   Title: Clinical, Pathologic, and Genetic Characteristics of Dementia with Lewy Bodies
   Lead Institutions: University of Washington
 
       Publications
28.   Bekris LM, Tsuang D, Leverenz JB, Yu CE, Lutz F, Lopez OL, Hamilton RL, Bennett DA, Schneider JA, Buchman AS, Larson EB, Crane PK, Kaye JA, Kramer P, Woltjer R, Trojanowski JQ, Weintraub D, Chen-Plotkin AS, Irwin DJ, Rick J, Schellenberg GD, Watson GS, Kukull W, Nelson PT, Jicha GA, Neltner JH, Galasko D, Masliah E, Quinn JF, Chung KA, Yearout D, Mata IF, Edwards KL, Montine TJ, Zabetian CP. A TOMM40 SNP in APOE ε4 Non-carriers Increases Risk for Multiple Types of Dementia. Alzheimers and Dementia, 9:P555, 2013. (Abstract)

29.   Chow SW, Peterson M, Vavrek DJ, Steinbart E, Bird TD, Leverenz JB, Tsuang DW. Diagnostic Accuracy of Concomitant Lewy-Related Pathology in a Kindred with Familial Alzheimer's Disease: a Clinical-Neuropathological Study. Summer Training on Aging Research Topics in Mental Health (START-MH), 2006. (Abstract)

30.   Ericksen S, Tsuang DW. Dementia with Lewy bodies. In: Fuji D, Ahmed I, eds Spectrum Psychotic Disorders: Neurobiology, Etiology & Pathogenesis New York: Cambridge University Press, 472-489, 2007.

31.   Leverenz JB, Fishel MA, Peskind ER, Montine TJ, Nochlin D, Steinbart E, Raskind MA, Schellenberg GD, Bird TD, Tsuang D. Lewy body pathology in familial Alzheimer disease - Evidence for disease- and mutation-specific pathologic phenotype. Arch Neurol, 63:370-376, 2006, PMC1892620.

32.   Leverenz JB, Hamilton R, Tsuang DW, Schantz A, Vavrek D, Larson EB, Kukull WA, Lopez O, Galasko D, Masliah E, Kaye J, Woltjer R, Clark C, Trojanowski JQ, Montine TJ. Empiric refinement of the pathologic assessment of Lewy-related pathology in the dementia patient. Brain Pathol, 18:220-224, 2008, PMC2689097.

33.   Leverenz JB, Hamilton RL, Tsuang DW, Schantz A, Vavrek D, Larson EB, Kukull WA, Lopez OL, Galasko D, Masliah E, Kaye J, Nixon R, Clark C, Trojanowski J, Montine TJ. Empirical refinement of pathologic assessment of Dementia with Lewy Bodies. Alzheimer's and Dementia, 2006. (Abstract)

34.   Leverenz JB, Larson EB, Vavrek D, Peskind ER, Bowen JD, McCormick WC, Teri L, Kukull WA, Montine TJ and Tsuang DW. "Amygdala predominant" Lewy body disease: a subtype of Alzheimer's disease with a more aggressive clinical course. Alzheimer's and Dementia, 2:S16, 2006. (Abstract)

35.   Lopez A, Samii A, Griffith A, Roberts J, Leis B, Mosley A, Yearout D, Schellenberg G, Bird T, Raskind W, Leverenz J, Tsuang D, Zabetian C. Comprehensive mutational analysis of LRRK2 in familial Parkinson's disease and dementia with Lewy bodies. Neurology, 66:277, 2006. (Abstract)

36.   Mata IF, Samii A, Schneer SH, Roberts JW, Griffith A, Leis BC, Schellenberg GD, Sidransky E, Bird TD, Leverenz JB, Tsuang D, Zabetian CP. Glucocerebrosidase gene mutations: a risk factor for lewy body disorders. Arch Neurol, 65:379-382, 2008, PMC2826203.

37.   Mata IF, Schneer SH, Samii A, Roberts JW, Griffith AF, Leis BC, Leverenz JB, Schellenberg GD, Sidransky E, Tsuang DW, Zabetian CP. Case-control analysis of glucocerebrosidase gene mutations in Parkinson's disease and dementia with Lewy bodies. Movement Disorders, 22:S128-S129, 2007. (Abstract)

38.   Nakashima-Yasuda H, Uryu K, Robinson J, Xie SX, Hurtig H, Duda JE, Arnold SE, Siderowf A, Grossman M, Leverenz JB, Woltjer R, Lopez OL, Hamilton R, Tsuang DW, Galasko D, Masliah E, Kaye J, Clark CM, Montine TJ, Lee VM, Trojanowski JQ. Co-morbidity of TDP-43 proteinopathy in Lewy body related diseases. Acta Neuropathol, 114:221-229, 2007.

39.   Ohtake H, Limprasert P, Fan Y, Onodera O, Kakita A, Takahashi H, Bonner LT, Tsuang DW, Murray IV, Lee VM, Trojanowski JQ, Ishikawa A, Idezuka J, Murata M, Toda T, Bird TD, Leverenz JB, Tsuji S, La Spada AR. Beta-synuclein gene alterations in dementia with Lewy bodies. Neurology, 63:805-811, 2004, PMC1808539.

40.   Schneer S, Mata IF, Samii A, Roberts JW, Griffith A, Leis BC, Leverenz JB, Schellenberg GD, Sidransky E, Tsuang DW, Zabetian CP. Case-control Analysis of Glucocerebrosidase Gene Mutations in Parkinson's Disease and Dementia with Lewy Bodies. American Academy of Neurology, 2007. (Abstract)

41.   Tsuang D, Larson EB, Bolen E, Thompson ML, Peskind E, Bowen J, McCormick W, Teri L, Kukull W, Vavrek D, Montine T, Leverenz JB. Visual hallucinations in dementia: a prospective community-based study with autopsy. Am J Geriatr Psychiatry, 17:317-323, 2009, PMC2742470.

42.   Tsuang D, Leverenz JB, Lopez OL, Hamilton RL, Bennett DA, Schneider JA, Buchman AS, Larson EB, Crane PK, Kaye JA, Kramer P, Woltjer R, Kukull W, Nelson PT, Jicha GA, Neltner JH, Galasko D, Masliah E, Trojanowski JQ, Schellenberg GD, Yearout D, Huston H, Fritts-Penniman A, Mata IF, Wan JY, Edwards KL, Montine TJ, Zabetian CP. GBA mutations increase risk for Lewy body disease with and without Alzheimer disease pathology. Neurology, 79:1944-1950, 2012, PMC3484986.

43.   Tsuang D, Simpson K, Larson EB, Peskind E, Kukull W, Bowen JB, McCormick W, Teri L, Montine T, Thompson ML, Leverenz JB. Predicting lewy body pathology in a community-based sample with clinical diagnosis of Alzheimer's disease. J Geriatr Psychiatry Neurol, 19:195-201, 2006.

44.   Tsuang DW, Hamilton RL, Lopez OL, Wilson R, Luedecking-Zimmer E, Kamboh L, DeKosky ST, Larson EB, Kukull WA, Schellenberg GD, Leverenz J. Age and concomitant LB pathology modify the genetic association between Alzheimer's disease and the APOE-e4 allele. 3rd International Workshop on Dementia with Lewy Bodies and Parkinson's Disease; Dementia Conference Handbook, 147, 2003. (Abstract)

45.   Tsuang DW, Larson EB, Peskind ER, Bowen JB, McCormick W, Teri L, Jennings-Vavrek D, Montine T, Thompson ML, Leverenz JB. Visual hallucinations and Lewy body pathology: a community-based autopsy case series. Alzheimer's and Dementia, 2:S146, 2006. (Abstract)

46.   Tsuang DW, Purganan K, Steinbart E, Bird TD, Montine T and Leverenz JB. Concomitant Lewy body pathology a marker for more aggressive course in familial Alzheimer's disease. Neurology, 64:A361-A362, 2005. (Abstract)

47.   Tsuang DW, Riekse R, Bird TD, Muilenberg M, Steinbart E, McCutcheon M, Purganan K, Leverenz JB. Familial Dementia with Lewy Bodies. Neurobiol Aging, 25:86, 2004. (Abstract)

48.   Tsuang DW, Riekse RG, Purganan KM, David AC, Montine TJ, Schellenberg GD, Steinbart EJ, Petrie EC, Bird TD, Leverenz JB. Lewy body pathology in late-onset familial Alzheimer's disease: A clinicopathological case series. J Alzheimers Dis, 9:235-242, 2006.

49.   Tsuang DW, Wilson RK, Lopez OL, Luedecking-Zimmer EK, Leverenz JB, DeKosky ST, Kamboh MI, Hamilton RL. Genetic association between the APOE*4 allele and Lewy bodies in Alzheimer disease. Neurology, 64:509-513, 2005, PMC1487185.

50.   Zabetian CP, Lauricella CJ, Tsuang DW, Leverenz JB, Schellenberg GD, Payami H. Analysis of the LRRK2 G2019S mutation in Alzheimer Disease. Arch Neurol, 63:156-157, 2006.


   Principal Investigator: Roger Rosenberg, MD (NACC Project #2002-01)
   Title: Statin Effects on Platelet APP Ratios and AD Dementia
   Lead Institutions: University of Texas Southwestern
 
       Publications
51.   Baskin F, Rosenberg RN, Fang X, Hynan LS, Moore CB, Weiner M, Vega GL. Correlation of platelet amyloid precursor protein ratios and declining cognition in Alzheimer's disease: A new severity index. Neurobiol Aging, 23:S384, 2002. (Abstract)

52.   Baskin F, Rosenberg RN, Fang X, Hynan LS, Moore CB, Weiner M, Vega GL. Correlation of statin-increased platelet APP ratios and reduced blood lipids in AD patients. Neurology, 60:2006-2007, 2003.

53.   Diaz-Arrastia R, Baskin F. New biochemical markers in Alzheimer disease. Arch Neurol, 58:354-356, 2001.

54.   Qu B, Boyer PJ, Johnston SA, Hynan LS, Rosenberg RN. Abeta42 gene vaccination reduces brain amyloid plaque burden in transgenic mice. J Neurol Sci, 244:151-158, 2006, PMC1531642.

55.   Qu B, Rosenberg RN, Li L, Boyer PJ, Johnston SA. Gene vaccination to bias the immune response to amyloid-beta peptide as therapy for Alzheimer disease. Arch Neurol, 61:1859-1864, 2004.

56.   Qu BX, Xiang Q, Li L, Johnston SA, Hynan LS, Rosenberg RN. Abeta42 gene vaccine prevents Abeta42 deposition in brain of double transgenic mice. J Neurol Sci, 260:204-213, 2007, PMC2587214.

57.   Tang K, Hynan LS, Baskin F, Rosenberg RN. Platelet amyloid precursor protein processing: a bio-marker for Alzheimer's disease. J Neurol Sci, 240:53-58, 2006, PMC1479090.


   Principal Investigator: Harry Vinters (NACC Project #2002-03)
   Title: Tissue Reactions to CAA Study Using Tissue Microarrays (CNS Complications of Amyloid Angiopathy)
   Lead Institutions: University of California, Los Angeles
 
       Publications
58.   Farag ES, Miyata H, Vinters HV. CAA severity and reactive change in Alzheimer disease: A tissue microarray study. J Neuropathol Exper Neurol, 62:553, 2003. (Abstract)

59.   Green DA, Masliah E, Vinters HV, Beizai P, Moore DJ, Achim CL. Brain deposition of beta-amyloid is a common pathologic feature in HIV positive patients. Aids, 19:407-411, 2005.

60.   Vinters HV, Klement IA, Sung SH, Farag ES. Pathologic issues and new methodologies in the evaluation of non-Alzheimer dementias. Clin Neuroscience Res, 3:413-426, 2004.


   Principal Investigator: Robert Sweet, MD (NACC Project #2002-04)
   Title: Genetics of Alzheimer’s Disease With Psychosis
   Lead Institutions: University of Pittsburgh
 
       Publications
61.   Bacanu SA, Devlin B, Chowdari KV, DeKosky ST, Nimgaonkar VL, Sweet RA. Heritability of psychosis in Alzheimer disease. Am J Geriatric Psychiatry, 13:624-627, 2005.

62.   Cook SE, Miyahara S, Bacanu SA, Perez-Madrinan G, Lopez OL, Kaufer DI, Nimgaonkar VL, Wisniewski SR, DeKosky ST, Sweet RA. Psychotic symptoms in Alzheimer disease: evidence for subtypes. Am J Geriatr Psychiatry, 11:406-413, 2003.

63.   Eror EA, Emanuel JE, Miyahara S, Lopez OL, DeKosky ST, Sweet RA. Excess Cognitive Impairment Precedes The Emergence Of Psychosis In Alzheimer Disease. Alzheimer's and Dementia, 2:S375-376, 2006. (Abstract)

64.   Eror EA, Lopez OL, DeKosky ST, Sweet RA. AD subjects with psychosis have increased subsyndromal psychotic symptoms prior to dementia onset. Neurobiol Aging, 25:S489, 2004. (Abstract)

65.   Eror EA, Lopez OL, Dekosky ST, Sweet RA. Alzheimer disease subjects with psychosis have increased schizotypal symptoms before dementia onset. Biol Psychiatry, 58:325-330, 2005.

66.   Go RC, Perry RT, Wiener H, Bassett SS, Blacker D, Devlin B, Sweet RA. Neuregulin-1 polymorphism in late onset Alzheimer's disease families with psychoses. Am J Med Genet Neuropsychiatr Genet, 139:28-32, 2005.

67.   Go RC, Perry RT, Wiener H, Bassett SS, Blacker D, Devlin BJ, Sweet RA. Neuregulin-1 polymorphism in load with psychosis in the NIMH AD sibling families. Neurobiol Aging, 25:S488, 2004. (Abstract)

68.   Lopez OL, Becker JT, Saxton J, Sweet RA, Klunk W, DeKosky ST. Alteration of a clinically meaningful outcome in the natural history of Alzheimer's disease by cholinesterase inhibition. J Am Geriatr Soc, 53:83-87, 2005.

69.   Lopez OL, Becker JT, Sweet RA, Hamilton RL, DeKosky ST. Relationship between major depression and Lewy bodies in Alzheimer's disease. Neurology, 62:A159-A160, 2004. (Abstract)

70.   Lopez OL, Becker JT, Sweet RA, Klunk W, Kaufer DI, Saxton J, DeKosky ST. Patterns of change in the treatment of psychiatric symptoms in patients with probable Alzheimer's disease from 1983 to 2000. J Neuropsychiatry Clin Neurosci, 15:67-73, 2003.

71.   Lopez OL, Becker JT, Sweet RA, Klunk W, Kaufer DI, Saxton J, Habeych M, DeKosky ST. Psychiatric symptoms vary with the severity of dementia in probable Alzheimer's disease. J Neuropsychiatry Clin Neurosci, 15:346-353, 2003.

72.   Lopez OL, Becker JT, Sweet RA, Klunk W, Saxton J, DeKosky ST. Incident psychiatric symptoms predict conversion to dementia in mild cognitive impairment subgroups. Neurobiol Aging, 25:S32, 2004. (Abstract)

73.   Lopez OL, Becker JT, Sweet RA. Non-cognitive symptoms in mild cognitive impairment subjects. Neurocase, 11:65-71, 2005.

74.   Lopez OL, Becker JT, Sweet RS, Klunk W, Saxton J, DeKosky ST. Response letter to Dr Thomas Finucane. J Am Geriatr Soc, 53:1831-1833, 2005.

75.   Lopez OL, Miyahara S, Becker JT, Sweet RA, Klunk W, Saxton J, DeKosky ST. Incident psychiatric symptoms predict conversion to dementia in Mild Cognitive Impairment subgroups. In: Vellas B, ed Research and Practice in Alzheimer's Disease and Cognitive Decline: Paris, Serdi, 89-95, 2005.

76.   Lopez OL. Incident Psychiatric symptoms predict the development of Mild Cognitive Impairment subgroups. Ninth International Conference on Alzheimer Disease and Related Disorders, 2004. (Presentation)

77.   Perez-Madrinan G, Cook SE, Saxton JA, Miyahara S, Lopez OL, Kaufer DI, Aizenstein HJ, DeKosky ST, Sweet RA. Alzheimer disease with psychosis: excess cognitive impairment is restricted to the misidentification subtype. J Geriatr Psychiatry, 12:449-456, 2004.

78.   Perez-Madrinan G, Cook SE, Saxton JA, Miyahara S, Lopez OL, Kaufer DI, Aizenstein HJ, DeKosky ST, Sweet RA. Psychosis in Alzheimer Disease: Excess Cognitive Impairment is Restricted to the Misidentification Subtype. Advances in Geriatric Psychiatry Translating Research Into Care:101, 2003. (Abstract)

79.   Prasad KMR, Davis SW, Becker JT, Keshavan MS, Sweet RA. Neurobiological substrates of Alzheimer Disease with psychosis: an exploratory study of structural MRI using a voxel-based morphometric approach. Society for Neuroscience 33rd Annual Meeting, 2003. (Abstract)

80.   Sweet R, Emanuel J E. Psychosis Secondary to Alzheimer Disease. In: Ahmed DFaI, ed The Spectrum of Psychotic Disorders: Neurobiology, Etiology, and Pathogenesis Cambridge UK: Cambridge University Press, 2005.

81.   Sweet RA, Bacanu SA, Devlin B, Chowdari KV, DeKosky ST, Nimgaonkar VL. Heritability of psychosis in Alzheimer disease. Neurobiol Aging, 25:S54, 2004. (Abstract)

82.   Sweet RA, Devlin B, Pollock BG, Sukonick DL, Kastango KB, Bacanu SA, Chowdari KV, DeKosky ST, Ferrell RE. Catechol-o-methyltransferase haplotype is associated with psychosis in Alzheimer's disease. American Association for Geriatric Psychiatry 17th Annual Meeting, Baltimore MD, 2004. (Abstract)

83.   Sweet RA, Devlin B, Pollock BG, Sukonick DL, Kastango KB, Bacanu SA, Kodavali VC, DeKosky ST, Ferrell RE. Catechol-o-methyltransferase haplotype is associated with psychosis in Alzheimer's disease. Molecular Psych, 10:1026-1036, 2005.

84.   Sweet RA. Genetics of Alzheimer Disease with Psychosis. SOBP Annual Convention and Scientific Program San Francisco California, 2003. (Presentation)

85.   Sweet RA. Heritability of Psychosis in Alzheimer Disease. Ninth International Conference on Alzheimer Disease and Related Disorders, 2004. (Abstract)

86.   Sweet RA. Recent Advances in the Clinical Neuroscience of Alzheimer's Disease. American Association for Geriatric Psychiatry 17th Annual Meeting, 2004. (Presentation)

87.   Sweet RA. Spanning the GAP: Genes, Alzheimer Disease, and Psychosis. Grand Rounds Mt Sinai School of Medicine, 2005. (Presentation)

88.   Sweet RA. Taking a New Look At Psychosis in Alzheimer's Disease. GRECC Weekly Conference Series, VA Hospital , Pittsburgh PA, 2003. (Presentation)

89.   Sweet RA. The genetic basis of psychosis in Alzheimer Disease (and why it matters). Geriatric Research, Education and Clinical Center (CRECC) conference series, 2006. (Presentation)

90.   Wilkosz PA, Miyahara S, Lopez O, Dekosky S, Sweet R. Psychotic symptoms identify subtypes of AD: A prospective validation study. Neurobiol Aging, 25:S495, 2004. (Abstract)

91.   Wilkosz PA, Miyahara S, Lopez OL, DeKosky ST, Eror EA, Sweet RA. HTR2A genotype, depression, and risk for psychosis onset in Alzheimer disease. Alzheimers and Dementia, 2:S183, 2006. (Abstract)

92.   Wilkosz PA, Miyahara S, Lopez OL, DeKosky ST, Sweet RA. HTR2A Genotype, Depression, And Risk For Psychosis Onset In Alzheimer Disease. Precedings of the International Congress on Geriatric Psychoneuropharmacology, 2005. (Abstract)

93.   Wilkosz PA, Miyahara S, Lopez OL, Dekosky ST, Sweet RA. Prediction of psychosis onset in Alzheimer disease: The role of cognitive impairment, depressive symptoms, and further evidence for psychosis subtypes. Am J Geriatr Psychiatry, 14:352-360, 2006.

 
       Externally-Funded Awards
94.   Bacanu SA. Method to detect genetic variants underlying psychiatric disease susceptibility. Young Investigator-NARSAD, 07/01/2003.

95.   Chowdari KV. Genetic Analysis of AD with Psychosis. Alzheimer Association-NIRG, 08/01/2003.

96.   Sweet RA. Prediction of Psychosis in Alzheimer's Disease. NIH/NIA, R01 AG027224, 07/01/2006.


   Principal Investigator: John Morris, MD (NACC Project #2001-03)
   Title: Neuropathologic Correlates of Nondemented Aging
   Lead Institutions: Washington University
 
       Publications
97.   Burack MA, Hartlein J, Flores HP, Taylor-Reinwald L, Perlmutter JS, Cairns NJ. In vivo amyloid imaging in autopsy-confirmed Parkinson disease with dementia. Neurology, 74:77-84, 2010, PMC2809026.

98.   Morris J. Neuropathologic Correlates of Non-demented Aging. In Washington University, 2001.

99.   Morris JC, Price JL, McKeel DW, Higdon R, Buckles VD. The Neuropathology of Nondemented Aging. Neurobiol Aging, 25:137, 2004. (Abstract)

100.   Price JL, McKeel Jr DW, Buckles VD, Roe CM, Xiong C, Grundman M, Hansen LA, Petersen RC, Parisi JE, Dickson DW, Smith CD, Davis DG, Schmitt FA, Markesbery WR, Kaye J, Kurlan R, Hulette C, Kurland BF, Higdon R, Kukull W, Morris JC. Neuropathology of nondemented aging: Presumptive evidence for preclinical Alzheimer disease. Neurobiol Aging, 30:1026-1036, 2009, PMC2737680.


   Principal Investigator: Elaine Peskind, MD (NACC Project #2001-04)
   Title: CSF Cortisol and APOE Genotype
   Lead Institutions: University of Washington
 
       Publications
101.   Abdi F, Quinn JF, Jankovic J, McIntosh M, Leverenz JB, Peskind E, Nixon R, Nutt J, Chung K, Zabetian C, Samii A, Lin M, Hattan S, Pan C, Wang Y, Jin J, Zhu D, Li GJ, Liu Y, Waichunas D, Montine TJ, Zhang J. Detection of biomarkers with a multiplex quantitative proteomic platform in cerebrospinal fluid of patients with neurodegenerative disorders. J Alzheimers Dis, 9:293-348, 2006.

102.   Friedman LF, Zeitzer JM, Lin L, Hoff D, Mignot E, Peskind ER, Yesavage JA. In Alzheimer disease, increased wake fragmentation found in those with lower hypocretin-1. Neurology, 68:793-794, 2007.

103.   Li G, Sokal I, Quinn JF, Leverenz JB, Brodey M, Schellenberg GD, Kaye JA, Raskind MA, Zhang J, Peskind ER, Montine TJ. CSF tau/Abeta42 ratio for increased risk of mild cognitive impairment: a follow-up study. Neurology, 69:631-639, 2007.

104.   Pan S, Wang Y, Quinn JF, Peskind ER, Waichunas D, Wimberger JT, Jin J, Li JG, Zhu D, Pan C, Zhang J. Identification of glycoproteins in human cerebrospinal fluid with a complementary proteomic approach. J Proteome Res, 5:2769-2779, 2006.

105.   Pan S, Zhu D, Quinn JF, Peskind ER, Montine TJ, Lin B, Goodlett DR, Taylor G, Eng J, Zhang J. A combined dataset of human cerebrospinal fluid proteins identified by multi-dimensional chromatography and tandem mass spectrometry. Proteomics, 7:469-473, 2007.

106.   Pasinetti GM, Ungar LH, Lange DJ, Yemul S, Deng H, Yuan X, Brown RH, Cudkowicz ME, Newhall K, Peskind E, Marcus S, Ho L. Identification of potential CSF biomarkers in ALS. Neurology, 66:1218-1222, 2006.

107.   Peskind ER, Griffin WS, Akama KT, Raskind MA, Van Eldik LJ. Cerebrospinal fluid S100B is elevated in the earlier stages of Alzheimer's disease. Neurochem Int, 39:409-413, 2001.

108.   Peskind ER, Li G, Shofer J, Quinn JF, Kaye JA, Clark CM, Farlow MR, DeCarli C, Raskind MA, Schellenberg GD, Lee VM, Galasko DR. Age and apolipoprotein E*4 allele effects on cerebrospinal fluid beta-amyloid 42 in adults with normal cognition. Arch Neurol, 63:936-939, 2006.

109.   Peskind ER, Wilkinson CW, Petrie EC, Schellenberg GD, Raskind MA. Increased CSF cortisol in AD is a function of APOE genotype. Neurology, 56:1094-1098, 2001.

110.   Riekse RG, Li G, Petrie EC, Leverenz JB, Vavrek D, Vuletic S, Albers JJ, Montine TJ, Lee VM, Lee M, Seubert P, Galasko D, Schellenberg GD, Hazzard WR, Peskind ER. Effect of statins on Alzheimer's disease biomarkers in cerebrospinal fluid. J Alzheimers Dis, 10:399-406, 2006.

111.   Vuletic S, Peskind ER, Marcovina SM, Quinn JF, Cheung MC, Kennedy H, Kaye JA, Jin LW, Albers JJ. Reduced CSF PLTP activity in Alzheimer's disease and other neurologic diseases; PLTP induces ApoE secretion in primary human astrocytes in vitro. J Neurosci Res, 80:406-413, 2005.

112.   Vuletic S, Riekse RG, Marcovina SM, Peskind ER, Hazzard WR, Albers JJ. Statins of different brain penetrability differentially affect CSF PLTP activity. Dement Geriatr Cogn Disord, 22:392-398, 2006.

113.   Xu J, Chen J, Peskind ER, Jin J, Eng J, Pan C, Montine TJ, Goodlett DR, Zhang J. Characterization of proteome of human cerebrospinal fluid. Int Rev Neurobiol, 73:29-98, 2006.

114.   Zhang H, Loriaux P, Eng J, Campbell D, Keller A, Moss P, Bonneau R, Zhang N, Zhou Y, Wollscheid B, Cooke K, Yi EC, Lee H, Peskind ER, Zhang J, Smith RD, Aebersold R. UniPep--a database for human N-linked glycosites: a resource for biomarker discovery. Genome Biol, 7:R73, 2006, PMC1779586.

115.   Zhang J, Goodlett DR, Peskind ER, Quinn JF, Zhou Y, Wang Q, Pan C, Yi E, Eng J, Aebersold RH, Montine TJ. Quantitative proteomic analysis of age-related changes in human cerebrospinal fluid. Neurobiol Aging, 26:207-227, 2005.

116.   Zhang J, Goodlett DR, Quinn JF, Peskind E, Kaye JA, Zhou Y, Pan C, Yi E, Eng J, Wang Q, Aebersold RH, Montine TJ. Quantitative proteomics of cerebrospinal fluid from patients with Alzheimer disease. J Alzheimers Dis, 7:125-133, 2005.

 
       Externally-Funded Awards
117.   Raskind M. Psychopathology of Alzheimer's: APOE and the HPA Axis. NIH/NIA, R01 AG008419, 07/01/2001.

118.   Riekse R. Differential Effects of Statins on A-Beta in Cerebrospinal Fluid. Merck - AFAR, 07/01/2003.

119.   Zhang J. Biomarkers for Parkinson's Disease (PD) and PD Dementia. NIH/NIA, R01 AG025327, 09/01/2004.

120.   Zhang J. CSF Biomarkers for Parkinson's Disease. Michael J Fox Foundation, 07/01/2005.


   Principal Investigator: Norman Foster (NACC Project #2000-04)
   Title: Collaborative PET Imaging Study
   Lead Institutions: University of Michigan
 
       Publications
121.   Foster NL, Barbas NR, Heidebrink JL, Turner RS, Clark CM, Jagust WJ, Arnold SE, DeCarli CS, Koeppe RA and Higdon R. Adding FDG-PET to clinical information improves the accuracy of dementia diagnosis. Neurobiol Aging, 25:372, 2004. (Abstract)

122.   Foster NL, Heidebrink JL, Clark CM, Jagust WJ, Arnold SE, Barbas NR, DeCarli C, Turner RS, Koeppe RA, Higdon R, Minoshima S. Inter-rater reliability and diagnostic accuracy of FDG-PET is superior to clinical history and examination in dementia. Neurobiol Aging, 23:S353, 2002. (Abstract)

123.   Foster NL, Heidebrink JL, Clark CM, Jagust WJ, Arnold SE, Barbas NR, DeCarli CS, Turner RS, Koeppe RA, Higdon R, Minoshima S. FDG-PET improves accuracy in distinguishing frontotemporal dementia and Alzheimer's disease. Brain, 130:2616-2635, 2007.

124.   Foster NL, Koeppe RA, Rogers V, Minoshima S, Clark CM, Jagust WJ, Arnold SE, Barbas NR, DeCarli CS, Heidebrink JL, Turner RS, Higdon R. A multi-center trial to evaluate the clinical utility of FDG-PET. 2nd meeting of the Alzheimer's Imaging Consortium, 2002. (Abstract)

125.   Foster NL, Koeppe RE, Giordani BJ, Nichols TE, Lieberman AP. Variations of the phenotype in frontotemporal dementias. In: Cummings J, Hardy J, Poncet M, Christen Y, eds Genotype - Proteotype - Phenotype Relationships in Neurodegenerative Diseases Berlin: Spinger-Verla, 139-152, 2005.

126.   Foster NL, Poynter JA, Heidebrink JL, Jagust WJ, Clark CM, Turn RS, Barbas NR, Arnold SE, DeCarli C, Koeppe RA, Higdon R, Minoshima S. Good diagnostic inter-rater reliability in a multicenter study of FDG-PET in the evaluation of dementia. Neurology, 58:S3, 2002. (Abstract)

127.   Foster NL. FDG PET in the Diagnosis of Frontotemporal Dementia. Biol Psychiatry, 57:45, 2005. (Abstract)

128.   Foster NL. Validating FDG-PET as a biomarker for frontotemporal dementia. Exper Neurol, 184:S2-8, 2003.

129.   Gabel MJ, Foster NL, Heidebrink JL, Higdon R, Aizenstein HJ, Arnold SE, Barbas NR, Boeve BF, Burke JR, Clark CM, Dekosky ST, Farlow MR, Jagust WJ, Kawas CH, Koeppe RA, Leverenz JB, Lipton AM, Peskind ER, Turner RS, Womack KB, Zamrini EY. Validation of consensus panel diagnosis in dementia. Arch Neurol, 67:1506-1512, 2010, PMC3178413.

130.   Heidebrink JL, Barbas NR, Turner RS, Clark CM, Jagust WJ, Arnold SE, DeCarli CS, Koeppe RA, Higdon R, Foster NL. FDG-PET improves differential diagnosis of dementia when clinical history and examination are ambiguous. Neurobiol Aging, 25:370, 2004. (Abstract)

131.   Womack KB, Diaz-Arrastia R, Aizenstein HJ, Arnold SE, Barbas NR, Boeve BF, Clark CM, DeCarli CS, Jagus, WJ, Leverenz JB, Peskind ER, Turner S, Zamrini EY, Heidebrink JL, Burke JR, DeKosky ST, Farlow MR, Gabel MJ, Higdon R, Kawas CH, Koeppe RA, Lipton AM, Foster NL. Temporoparietal Hypometabolism in Frontotemporal Lobar Degeneration and Associated Imaging Diagnostic Errors. Arch Neurol, 68:329-337, 2011, PMC3058918.

132.   Higdon R, Foster NL, Koeppe RA, DeCarli CS, Jagust WJ, Clark CM, Barbas NR, Arnold SE, Turner RS, Heidebrink JL, Minoshima S. A comparison of classification methods for differentiating fronto-temporal dementia from Alzheimer's disease using FDG-PET imaging. Stat Med, 23:315-326, 2004.

 
       Externally-Funded Awards
133.   Foster N. Pilot Collaborative PET Imaging Study. NIH/NIA, R01 AG022394, 09/30/2003.


   Principal Investigator: Douglas Galasko, MD (NACC Project #2000-05)
   Title: Clinico-pathologic Studies in Fronto-Temporal Dementia
   Lead Institutions: University of California, San Diego
 
       Publications
134.   Rascovsky K, Salmon D, Clark C, DeCarli C, Graff-Radford N, Leverenz J, Galasko D. Rate of progression differs in frontotemporal dementia and Alzheimer's disease. Neurology, 62:A344, 2004. (Abstract)

135.   Rascovsky K, Salmon DP, Lipton AM, Leverenz JB, DeCarli C, Jagust WJ, Clark CM, Mendez MF, Tang-Wai DF, Graff-Radford NR, Galasko D. Rate of progression differs in frontotemporal dementia and Alzheimer disease. Neurology, 65:397-403, 2005.


   Principal Investigator: John Growdon, MD (NACC Project #2000-06)
   Title: Consortium on Alzheimer’s Genetics
   Lead Institutions: Massachusetts ADRC
 
       Publications
136.   Bertram L, Hiltunen M, Parkinson M, Ingelsson M, Lange C, Ramasamy K, Mullin K, Menon R, Sampson AJ, Hsiao MY, Elliott KJ, Velicelebi G, Moscarillo T, Hyman BT, Wagner SL, Becker KD, Blacker D, Tanzi RE. Family-based association between Alzheimer's disease and variants in UBQLN1. N Engl J Med, 352:884-894, 2005.

137.   Bertram L, Hsiao M, Mullin K, Parkinson M, Menon R, Moscarillo TJ, Blacker D, Tanzi RE. ACAT1 is not associated with Alzheimer's disease in two independent family-based samples. Mol Psychiatry, 10:522-524, 2005.

138.   Bertram L, Parkinson M, McQueen MB, Mullin K, Hsiao M, Menon R, Moscarillo TJ, Blacker D, Tanzi RE. Further evidence for LBP-1c/CP2/LSF association in Alzheimer's disease families. J Med Genet, 42:857-862, 2005.

139.   Bertram L, Tanzi RE. Author reply: The Ubiquitin 1 gene and Alzheimer's disease. N Engl J Med, 352:26, 2005.

140.   Mullin K, Bertram L, Moscarillo T, Becker KD, Wang C, Growdon J, Blacker D, Tanzi RE, tCAGS Group. Genetic association within the IDE region on chromosome 10-the consortium on Alzheimer's genetics (CAG). 33rd annual meeting of the Society for Neuroscience, 2003. (Abstract)


   Principal Investigator: Michael Grundman, MD PhD (NACC Project #3)
   Title: A Multi-Center Collaboration to Evaluate Candidate Agents for AD Prevention Trials
   Lead Institutions: University of California, San Diego
 
       Publications
141.   Grundman M. Antioxidant Supplements are Associated with a Lower Risk of Developing Mild Cognitive Impairment or Alzheimer's Disease among Healthy Elderly Volunteers. Neuroscience, 546:516, 2001. (Abstract)

142.   Grundman M. The Alzheimer's Disease Centers' Neuropsychological Database Initiative: A Resource for Alzheimer's Disease Prevention Trials. In: Alzheimer's Disease: Advances in Etiology, Pathogenesis and Therapeutics New York: Wiley, 2001.

143.   Ji M, Xiong C, Grundman M. Hypothesis testing of a change point during cognitive decline among Alzheimer's disease patients. J Alzheimers Dis, 5:375-382, 2003.


   Principal Investigator: Neil Kowall, MD (NACC Project #5)
   Title: Collaborative Study Group on Vascular Pathology
   Lead Institutions: Boston University
 
       Publications
144.   McKee A, Au R, Cabral H, Auerbach S, Green R, Kowall N, Wolf P. Microvascular lesions distinguish cognitively impaired subjects without Alzheimer's disease from unimpaired subjects: Findings from the Framingham Heart Study. Vas Cog, 2005. (Abstract)

145.   Yip AG, McKee A, Wells J, Green RC, Young H, Cupples LA, Farrer LA. APOE, vascular pathology, and the AD brain. Neurobiol Aging, 25:403, 2004. (Abstract)

146.   Yip AG, McKee AC, Green RC, Wells J, Young H, Cupples LA,Farrer LA. APOE, vascular pathology, and the AD brain. Neurology, 65:2259-265, 2005.

 
       Externally-Funded Awards
147.   Wolf P. Epidemiology of dementia in the Framingham cohort. NIH/NIA, R01 AG08122, 06/01/2000.


   Principal Investigator: Bernardino Ghetti (NACC Project #8)
   Title: Identification of Atypical Dementias from Neuropathology to Molecular Etiology
   Lead Institutions: Indiana University
 
       Publications
148.   Adamec E, Murrell JR, Takao M, Hobbs W, Nixon RA, Ghetti B, Vonsattel JP. P301L tauopathy: confocal immunofluorescence study of perinuclear aggregation of the mutated protein. J Neurol Sci, 200:85-93, 2002.

149.   Azzarelli B, Miravalle L, Olson J, Ghetti B, Biller J, Vidal R. CADASIL: A familial form of cerebrovascular disease leading to dementia Identification of two new families and a novel mutation. Neurology, 60:A368-A369, 2003. (Abstract)

150.   Byrne NP, Ito M, Takao M, Miravalle L, Murrell JR, Ghetti B, Powers JM. A novel form of senile dementia neuropathologically characterized by frontotemporal degeneration and leukoencephalopathy associated with a severe tau deposition predominantly in glia. J Neuropathol Exper Neurol, 61:460, 2002. (Abstract)

151.   Cochran EJ, Murrell JR, Fox J, Ringman J, Ghetti B. A novel mutation in the presenilin 1 (PS1) gene (A431E) associated with early-onset Alzheimer disease. J Neuropathol Exper Neurol, 60:544, 2001. (Abstract)

152.   Davis RL, Shrimpton AE, Carrell RW, Lomas DA, Gerhard L, Baumann B, Lawrence DA, Yepes M, Kim TS, Ghetti B, Piccardo P, Takao M, Lacbawan F, Muenke M, Sifers RN, Bradshaw CB, Kent PF, Collins GH, Larocca D, Holohan PD. Association between conformational mutations in neuroserpin and onset and severity of dementia. Lancet, 359:2242-2247, 2002.

153.   Delisle MB, Uro-Coste E, Rascol O, Sinani V, Piccardo P, Takao M, Vidal R, Ghetti B. A neurodegenerative disease with intranuclear deposits: clinical and neuropathologic studies. J Neuropathol Exper Neurol, 60:514, 2001. (Abstract)

154.   Farlow MR, Murrell JR, Unverzagt FW, Phillips M, Takao M, Hulette C, Ghetti B. Familial Alzheimer's Disease with Spastic Paraparesis Associated with a Mutation at Codon 261 of the Presenilin 1 Gene Therapeutics. In: Iqbal K, Sisodia SS, Winblad B, eds Alzheimer's Disease: Advances in Etiology, Pathogenesis and Therapeutics Chichester: John Wiley and Sons Ltd, 53-60, 2001.

155.   Ghetti B, Piccardo P, Parisi J, Takao M, Dlouhy S, Cochran EJ, Fox JH. Gerstmann-Straussler-Scheinker (GSS) disease with neurofibrillary tangles and PrP-amyloid plaques: a new family. J Neuropathol Exper Neurol, 60:537, 2001. (Abstract)

156.   Hattab EM, Murrell JR, Yamaguchi K, Unverzagt FW, Foroud T, Miravalle L, Takao M, Hulette C, Vidal R, Farlow MR, Ghetti B. Widespread Abeta angiopathy, cotton wool plaques and pyramidal tract degeneration are the main neuropathologic features associated with the V261F mutation in the Presenilin 1 gene. J Neuropathol Exper Neurol, 62, 2003. (Abstract)

157.   Miravalle L, Murrell JR, Takao M, Glazier B, Piccardo P, Vidal R, Ghetti B. Genetic mutations associated with presenile dementia. Neurobiol Aging, 23:S322, 2002. (Abstract)

158.   Miravalle L, Murrell JR, Takao M, Richardson R, Bassett SS, Crain B, Ghetti B. Hippocampal pathology in patients with FTDP-17 and a mutation in the intron following exon 10 (+16) of the tau gene. J Neuropathol Exper Neurol, 60:548, 2001. (Abstract)

159.   Murrell JF, Miravalle L, Foster NL, Albin R, Takao M, Ghetti B. Early-onset familial Alzheimer disease (AD) from the first American report: a presenilin 1 (PS1) mutation found in descendants. J Neuropathol Exper Neurol, 60:543, 2001. (Abstract)

160.   Murrell JR, Faber K, Alonso ME, Rasmussen A, Varpetian A, Macias MA, Cochran E, Gambetti P, Castellani RJ, Bauserman SC, Foroud T, Vidal R, Miravalle L, Ghetti B, Ringman JM. The A431E Presenilin 1 gene mutation associated with familial Alzheimer disease in individuals of Mexican descent: evidence for a founder effect. J Neuropathol Exper Neurol, 62, 2003. (Abstract)

161.   Piccardo P, William A, Dlouhy SR, Farlow MR, Takao M, Ghetti B. Two nonglycosylated prion protein (PrP) isoforms coexist within the same microregions in the brain of some individuals with sporadic Creutzfeldt-Jakob disease (sCJD). Exper Neurol, 60:549, 2001. (Abstract)

162.   Powers JM, Byrne NP, Ito M, Takao M, Yankopoulou D, Spillantini MG, Ghetti B. A novel leukoencephalopathy associated with tau deposits primarily in white matter glia. Acta Neuropathol, 106:181-187, 2003.

163.   Rascol O, Goizet C, Labauge P, Delisle MB, Vidal R, Calvas P, Ghetti B. A novel autosomic dominant movement disorder with intranuclear ferritin containing inclusions. Neurology, 60, 2003. (Abstract)

164.   Ringman JM, Jain V, Murrell J, Ghetti B, Cochran EJ. Human Gene Mutations: Gene Symbol: PSEN1. Hum Genetics, 109:242, 2001. (Abstract)

165.   Takao M, Ghetti B, Hayakawa I, Ikeda E, Fukuuchi Y, Miravalle L, Piccardo P, Murrell JR, Glazier BS, Koto A. A novel mutation (G217D) in the Presenilin 1 gene (PSEN1) in a Japanese family: presenile dementia and parkinsonism are associated with cotton wool plaques in the cortex and striatum. Acta Neuropathol, 104:155-170, 2002.

166.   Takao M, Ghetti B, Murrell JR, Unverzagt FW, Giaccone G, Tagliavini F, Bugiani O, Piccardo P, Hulette CM, Crain BJ, Farlow MR, Heyman A. Ectopic white matter neurons, a developmental abnormality that may be caused by the PSEN1 S169L mutation in a case of familial AD with myoclonus and seizures. J Neuropathol Exp Neurol, 60:1137-1152, 2001.

167.   Takao M, Ghetti B, Yoshida H, Piccardo P, Narain Y, Murrell JR, Vidal R, Glazier BS, Jakes R, Tsutsui M, Spillantini MG, Crowther RA, Goedert M, Koto A. Early-onset dementia with Lewy bodies. Brain Pathol, 14:137-147, 2004.

168.   Takao M, Hayakawa I, Ikeda E, Koto A, Fukuuchi Y, Miravalle L, Piccardo P, Murrell JR, Ghetti B. A novel mutation (G217D) in the presenilin 1(PS1) gene associated with familial presenile dementia and Parkinsonism in a Japanese family. J Neuropathol Exp Neurol, 60:543, 2001. (Abstract)

169.   Takao M, Murrell J, Piccardo P, Unverzagt FW, Farlow MR, Vidal R, Miravalle L, Glazier BS, Stuck J, Foroud T, Ghetti B. Presenilin 1 mutation P264L associated with presenile dementia, cotton wool plaques and diffuse Lewy bodies. J Neuropathol Exp Neurol, 61:7, 2002. (Abstract)

170.   Takao M, Narain Y, Spillantini MG, Piccardo P, Murrell JR, Vidal R, Crowther RA, Goedert M, Ghetti B, Koto A. Atypical form of diffuse Lewy body disease with onset at 13 years of age. J Neuropathol Exp Neurol, 61:459, 2002. (Abstract)

171.   Takao M, Piccardo P, Murrell J, Miravalle L, Vidal R, Brashear A, Foster N, Towfighi J, Farlow M, Unverzagt F, Koto A, Hulette C, Conneally PM, Foroud T, Cochran E, Glazier B. Neuropathologic heterogeneity associated with Presenilin 1 gene mutations. Neurobiol Aging, 23:S417, 2002. (Abstract)

172.   Vidal R, Azzarelli B, Miravalle L, Olson J, Nukes T, Biller J, Ghetti B. CADASIL in two North American Caucasian families. J Neuropathol Exper Neurol, 62, 2003. (Abstract)

173.   Vidal R, Benson MD, Liepnieks JM, Yazaki M, Miravalle L, Uro-Coste E, Delisle MB, Ghetti B. A neurodegenerative disease with intranuclear protein deposits: electron microscopic and biochemical studies. J Neuropathol Exper Neurol, 60:515, 2001. (Abstract)

174.   Vidal R, Delisle MB, Ghetti B. Neurodegeneration caused by proteins with an aberrant carboxyl-terminus. J Neuropathol Exp Neurol, 63:787-800, 2004.

175.   Vidal R, Delisle MB, Liepnieks JJ, Uro-Coste E, Yazaki M, Rascol O, Siani V, Miravalle L, Takao M, Piccardo P, Calvas P, Benson MD, Ghetti B. CNS and systemic deposition of ferritin and iron associated with a novel autosomal dominant neurodegenerative disease. J Neurosci, 573:14, 2001. (Abstract)

176.   Vidal R, Delisle MB, Rascol O, Ghetti B. Hereditary ferritinopathy. J Neurol Sci, 207:110-111, 2003.

177.   Vidal R, Delisle MB, Takao M, Miravalle L, Uro-Coste E, Liepnieks JJ, Yazaki M, Siani V, Piccardo P, Calvas P, Murrell J, Benson MD, Rascol O, Ghetti B. A familial adult-onset autosomal dominant neurodegenerative disease associated with cytoplasmic and intranuclear accumulation of ferritin. Neurobiol Aging, 23:S205, 2002. (Abstract)

178.   Vidal R, Delisle MB, Takao M, Miravalle L, Uro-Coste E, Liepnieks JJ, Yazaki M, Siani V, Piccardo P, Calvas P, Murrell JR, Benson MD, Rascol O, Ghetti B. A familial autosomal dominant disease associated with intracytoplasmic and intranuclear ferritin accumulation. Clin Neuropathol, 21:136-137, 2002. (Abstract)

179.   Vidal R, Delisle MB, Takao M, Miravalle L, Uro-Coste E, Liepnieks JJ, Yazaki M, Sinai V, Piccardo P, Calvas P, Benson MD, Rascol, O, Ghetti B. Autosomal dominant neurodegenerative disease associated with accumulation of ferritin. J Neuropathol Exper Neurol, PG55, 2002. (Abstract)

180.   Vidal R, Delisle MB, Takao M, Uro-Coste E, Calvas P, Benson MD, Miravalle L, Rascol O, Ghetti B. Intracellular ferritin accumulation in neural and extraneural tissue characterizes a neurodegenerative disease associated with a TC insertion in exon 4 of the Ferritin Light Polypeptide (FTL) gene. Neurology, 62:A177, 2004. (Abstract)

181.   Vidal R, Ghetti B, Takao M, Brefel-Courbon C, Uro-Coste E, Glazier BS, Siani V, Benson MD, Calvas P, Miravalle L, Rascol O, Delisle MB. Intracellular ferritin accumulation in neural and extraneural tissue characterizes a neurodegenerative disease associated with a mutation in the ferritin light polypeptide gene. J Neuropathol Exp Neurol, 63:363-380, 2004.

182.   Vidal R, Piccardo P, Miravalle L, Takao M, Frangione B, Ghetti B. Senile dementia associated with Ab angiopathy and tau perivascular pathology but not neuritic plaques in patients homozygous for the APOE 4 allele. J Neuropathol Exper Neurol, PG54, 2002. (Abstract)

183.   Yamaguchi K, Miravalle L, Piccardo P, Murrell JR, Foroud T, Vidal R, Unverzagt FW, Farlow MR, Ghetti B. Phenotypic variability associated with the Presenilin 2 N141I mutation in individuals of Volga-German descent. J Neuropathol Exper Neurol, 62:543, 2003. (Abstract)

 
       Externally-Funded Awards
184.   Vidal R. Ferritin Induced Neurodegeneration. NIH/NINDS, R01 NS050227, 07/15/2005.


   Principal Investigator: Chris Clark (NACC Project #Clark)
   Title: Does the onset of AD differ in Latinos
   Lead Institutions: Univ of Pennsylvania
 
       Publications
185.   Clark CM, DeCarli C, Mungas D, Chui H, Higdon R, Nunez J, Fernandez H, Negron M, Manly J, Hernandez I, Ferris S, Perez A, Torres M, Ewbank D, Glosser G, van Belle G. Latino patients with Alzheimer's disease have an earlier age of symptom onset compared to Anglos. Neurobiol Aging, 25:S106, 2004. (Abstract)

186.   Clark CM, DeCarli C, Mungas D, Chui HI, Higdon R, Nunez J, Fernandez H, Negron M, Manly J, Ferris S, Perez A, Torres M, Ewbank D, Glosser G, van Belle G. Earlier onset of Alzheimer disease symptoms in Latino individuals compared with Anglo individuals. Arch Neurol, 62:774-778, 2005.


   Principal Investigator: Michael Hughes (NACC Project #Hughes)
   Title: ADC Collaborative Networks
   Lead Institutions: Univ of Pennsylvania
 
       Publications
187.   Hughes ME, Peeler J, Hogenesch JB, Trojanowski JQ. The Growth and Impact of Alzheimer Disease Centers as Measured by Social Network Analysis. JAMA Neurology, 71:412-420, 2014, PMC4096555.


NACC - ADC Collaboration in External Studies(RFA-AG-03-005 and RFA-AG-05-006)(by project): (TOTAL of 73)

   Principal Investigator: Carl Cotman, PhD
   Title: Brain Aging and Gene Expression Patterns Using Microarrays
   Agency: NIA - RO1 AG023173
   Date Funded: 9/1/2003
 
       Publications
1.   Berchtold NC, Cribbs DH, Coleman PD, Rogers J, Head E, Kim R, Beach T, Miller C, Troncoso J, Trojanowski JQ, Zielke HR, Cotman CW. Gene expression changes in the course of normal brain aging are sexually dimorphic. Proc Natl Acad Sci U S A, 105:15605-15610, 2008, PMC2563070.

2.   Pan F, Chiu CH, Pulapura S, Mehan MR, Nunez-Iglesias J, Zhang K, Kamath K, Waterman MS, Finch CE, Zhou XJ. Gene Aging Nexus: a web database and data mining platform for microarray data on aging. Nucleic Acids Res, 35:D756-759, 2007, PMC1669755.

3.   Parachikova A, Agadjanyan MG, Cribbs DH, Blurton-Jones M, Perreau V, Rogers J, Beach TG, Cotman CW. Inflammatory changes parallel the early stages of Alzheimer disease. Neurobiol Aging, 28:1821-2833, 2007, PMC2198930.


   Principal Investigator: Douglas Galasko, MD
   Title: Biomarkers in Aging, MCI and Alzheimer’s Disease
   Agency: NIA - RO1 AG023185
   Date Funded: 9/1/2003
 
       Publications
4.   Portelius E, Bogdanovic N, Gustavsson MK, Volkmann I, Brinkmalm G, Zetterberg H, Winblad B, Blennow K. Mass spectrometric characterization of brain amyloid beta isoform signatures in familial and sporadic Alzheimer's disease. Acta Neuropathol, 120:185-193, 2010, PMC3568930.

5.   Li G, Peskind ER, Millard SP, Chi P, Sokal I, Yu CE, Bekris LM, Raskind MA, Galasko DR, Montine TJ. Cerebrospinal fluid concentration of brain-derived neurotrophic factor and cognitive function in non-demented subjects. PLoS ONE, 4:e5424, 2009, PMC2671606.

6.   Petrie EC, Cross DJ, Galasko D, Schellenberg GD, Raskind MA, Peskind ER, Minoshima S. Preclinical evidence of Alzheimer changes: convergent cerebrospinal fluid biomarker and fluorodeoxyglucose positron emission tomography findings. Arch Neurol, 66:632-637, 2009, PMC2718788.

7.   Peskind ER, Li G, Shofer J, Quinn JF, Kaye JA, Clark CM, Farlow MR, DeCarli C, Raskind MA, Schellenberg GD, Lee VM, Galasko D. Age and apolipoprotein E*4 allele effects on cerebrospinal fluid beta-amyloid 42 in adults with normal cognition. Arch Neurol, 63:936-939, 2006.

8.   Peskind ER, Riekse R, Quinn JF, Kaye J, Clark CM, Farlow MR, Decarli C, Chabal C, Vavrek D, Raskind MA, Galasko D. Safety and acceptability of the research lumbar puncture. Alzheimer Dis Assoc Disord, 19:220-225, 2005.


   Principal Investigator: Dietrich Stephan, PhD
   Title: Neurogenomics of Alzheimer’s Disease and Aging
   Agency: NIA - RO1 AG023193
   Date Funded: 9/1/2003
 
       Publications
9.   Liang WS, Chen K, Lee W, Sidhar K, Corneveaux JJ, Allen AN, Myers A, Villa S, Meechoovet B, Pruzin J, Bandy D, Fleisher AS, Langbaum JB, Huentelman MJ, Jensen K, Dunckley T, Caselli RJ, Kaib S, Reiman EM. Association between GAB2 haplotype and higher glucose metabolism in Alzheimer's disease-affected brain regions in cognitively normal APOEepsilon4 carriers. Neuroimage, 54:1896-1902, 2011, PMC3010232.

10.   Azorsa DO, Robeson RH, Frost D, Meec hoovet B, Brautigam GR, Dickey C, Beaudry C, Basu GD, Holz DR, Hernandez JA, Bisanz KM, Gwinn L, Grover A, Rogers J, Reiman EM, Hutton M, Stephan DA, Mousses S, Dunckley T. High-content siRNA screening of the kinome identifies kinases involved in Alzheimer's disease-related tau hyperphosphorylation. BMC Genomics, 11:25, 2010, PMCID2820455.

11.   Corneveaux JJ, Liang WS, Reiman EM, Webster JA, Myers AJ, Zismann VL, Joshipura KD, Pearson JV, Hu-Lince D, Craig DW, Coon KD, Dunckley T, Bandy D, Lee W, Chen K, Beach TG, Mastroeni D, Grover A, Ravid R, Sando SB, Aasly JO, Heun R, Jessen F, Kolsch H, Rogers J, Hutton ML, Melquist S, Petersen RC, Alexander GE, Caselli RJ, Papassotiropoulos A, Stephan DA, Huentelman MJ. Evidence for an association between KIBRA and late-onset Alzheimer's disease. Neurobiol Aging, 31:901-909, 2010, PMCID2913703.

12.   Corneveaux JJ, Myers AJ, Allen AN, Pruzin JJ, Ramirez M, Engel A, Nalls MA, Chen K, Lee W, Chewning K, Villa SE, Meechoovet HB, Gerber JD, Frost D, Benson HL, O'Reilly S, Chibnik LB, Shulman JM, Singleton AB, Craig DW, Van Keuren-Jensen KR, Dunckley T, Bennett DA, De Jager PL, Heward C, Hardy J, Reiman EM, Huentelman MJ. Association of CR1, CLU and PICALM with Alzheimer's disease in a cohort of clinically characterized and neuropathologically verified individuals. Hum Mol Genet, 19:3295-3301, 2010, PMC2908469.

13.   Liang WS, Dunckley T, Beach TG, Grover A, Mastroeni D, Ramsey K, Caselli RJ, Kukull WA, McKeel D, Morris JC, Hulette CM, Schmechel D, Reiman EM, Rogers J, Stephan DA. Neuronal gene expression in non-demented individuals with intermediate Alzheimer's Disease neuropathology. Neurobiol Aging, 31:549-566, 2010, PMC2844804.

14.   Liang WS, Dunckley T, Beach TG, Grover A, Mastroeni D, Ramsey K, Caselli RJ, Kukull WA, McKeel D, Morris JC, Hulette CM, Schmechel D, Reiman EM, Rogers J, Stephan DA. Altered neuronal gene expression in brain regions differentially affected by Alzheimer's disease: a reference data set. Physiol Genomics, 33:240-256, 2008, PMC2826117.

15.   Liang WS, Reiman EM, Valla J, Dunckley T, Beach TG, Grover A, Niedzielko TL, Schneider LE, Mastroeni D, Caselli R, Kukull W, Morris JC, Hulette CM, Schmechel D, Rogers J, Stephan DA. Alzheimer's disease is associated with reduced expression of energy metabolism genes in posterior cingulate neurons. Proc Natl Acad Sci U S A, 105:4441-4446, 2008, PMC2393743.

16.   Coon KD, Myers AJ, Craig DW, Webster JA, Pearson JV, Lince DH, Zismann VL, Beach TG, Leung D, Bryden L, Halperin RF, Marlowe L, Kaleem M, Walker DG, Ravid R, Heward CB, Rogers J, Papassotiropoulos A, Reiman EM, Hardy J, Stephan DA. A high-density whole-genome association study reveals that APOE is the major susceptibility gene for sporadic late-onset Alzheimer's disease. J Clin Psychiatry, 68:613-618, 2007.

17.   Liang WS, Dunckley T, Beach TG, Grover A, Mastroeni D, Walker DG, Caselli RJ, Kukull WA, McKeel D, Morris JC, Hulette C, Schmechel D, Alexander GE, Reiman EM, Rogers J, Stephan DA. Gene expression profiles in anatomically and functionally distinct regions of the normal aged human brain. Physiol Genomics, 28:311-322, 2007, PMC2259385.

18.   Reiman EM, Webster JA, Myers AJ, Hardy J, Dunckley T, Zismann VL, Joshipura KD, Pearson JV, Hu-Lince D, Huentelman MJ, Craig DW, Coon KD, Liang WS, Herbert RH, Beach T, Rohrer KC, Zhao AS, Leung D, Bryden L, Marlowe L, Kaleem M, Mastroeni D, Grover A, Heward CB, Ravid R, Rogers J, Hutton ML, Melquist S, Petersen RC, Alexander GE, Caselli RJ, Kukull W, Papassotiropoulos A, Stephan DA. GAB2 alleles modify Alzheimer's risk in APOE epsilon4 carriers. Neuron, 54:713-720, 2007, PMC2587162.

19.   Reiman EM. Linking brain imaging and genomics in the study of Alzheimer's disease and aging. Ann N Y Acad Sci, 1097:94-113, 2007.

20.   Coon KD, Siegel AM, Yee SJ, Dunckley TL, Mueller C, Nagra RM, Tourtellotte WW, Reiman EM, Papassotiropoulos A, Petersen FF, Stephan DA, Kirsch WM. Preliminary demonstration of an allelic association of the IREB2 gene with Alzheimer's disease. J Alzheimers Dis, 9:225-233, 2006, PMC1555623.

21.   Dunckley T, Beach TG, Ramsey KE, Grover A, Mastroeni D, Walker DG, LaFleur BJ, Coon KD, Brown KM, Caselli R, Kukull W, Higdon R, McKeel D, Morris JC, Hulette C, Schmechel D, Reiman EM, Rogers J, Stephan DA. Gene expression correlates of neurofibrillary tangles in Alzheimer's disease. Neurobiol Aging, 27:1359-1371, 2006, PMC2259291.

22.   Papassotiropoulos A, Fountoulakis M, Dunckley T, Stephan DA, Reiman EM. Genetics, transcriptomics, and proteomics of Alzheimer's disease. J Clin Psychiatry, 67:652-670, 2006.


   Principal Investigator: David Knopman, MD
   Title: Frontotemporal Dementia: Developing Drug Trial methods
   Agency: NIA - RO1 AG023195
   Date Funded: 9/1/2003
 
       Publications
23.   Bei H, Ross L, Neuhaus J, Knopman D, Kramer J, Boeve B, Caselli RJ, Graff-Radford N, Mendez MF, Miller BL, Boxer AL. Off-label medication use in frontotemporal dementia. Am J Alzheimers Dis Other Demen, 25:128-133, 2010, PMC2862544.

24.   Delucchi KL. MRS in presymptomatic MAPT mutation carriers: a potential biomarker for tau-mediated pathology. Neurology, 75:771-778, 2010, PMC2938968.

25.   Molano J, Boeve B, Ferman T, Smith G, Parisi J, Dickson D, Knopman D, Graff-Radford N, Geda Y, Lucas J, Kantarci K, Shiung M, Jack C, Silber M, Pankratz VS, Petersen R. Mild cognitive impairment associated with limbic and neocortical Lewy body disease: a clinicopathological study. Brain, 133:540-556, 2010, PMC2822633.

26.   Pakhomov SV, Smith GE, Chacon D, Feliciano Y, Graff-Radford N, Caselli R, Knopman DS. Computerized analysis of speech and language to identify psycholinguistic correlates of frontotemporal lobar degeneration. Cogn Behav Neurol, 23:165-177, 2010, PMC3365864.

27.   Vemuri P, Wiste HJ, Weigand SD, Knopman DS, Trojanowski JQ, Shaw LM, Bernstein MA, Aisen PS, Weiner M, Petersen RC, Jack CR Jr. Serial MRI and CSF biomarkers in normal aging, MCI, and AD. Neurology, 75:143-151, 2010, PMC2905929.

28.   Whitwell JL, Avula R, Senjem ML, Kantarci K, Weigand SD, Samikoglu A, Edmonson HA, Vemuri P, Knopman DS, Boeve BF, Petersen RC, Josephs KA, Jack, CR Jr. Gray and white matter water diffusion in the syndromic variants of frontotemporal dementia. Neurology, 74:1279-1287, 2010, PMC2860485.

29.   Whitwell JL, Jack CR Jr, Boeve BF, Parisi JE, Ahlskog JE, Drubach DA, Senjem ML, Knopman DS, Petersen RC, Dickson DW, Josephs KA. Imaging correlates of pathology in corticobasal syndrome. Neurology, 75:1879-1887, 2010, PMC2995388.

30.   Josephs KA, Whitwell JL, Knopman DS, Boeve BF, Vemuri P, Senjem ML, Parisi JE, Ivnik RJ, Dickson DW, Petersen RC, Jack Jr CR. Two distinct subtypes of right temporal variant frontotemporal dementia. Neurology, 73:1443-1450, 2009, PMC2779005.

31.   Knopman DS, Jack CR, Jr, Kramer JH, Boeve BF, Caselli RJ, Graff-Radford NR, Mendez MF, Miller BL, Mercaldo ND. Brain and ventricular volumetric changes in frontotemporal lobar degeneration over 1 year. Neurology, 72:1843-1849, 2009, PMC2690986.

32.   Lesage SR, Mosley TH, Wong TY, Szklo M, Knopman D, Catellier DJ, Cole SR, Klein R, Coresh J, Coker LH, Sharrett AR. Retinal microvascular abnormalities and cognitive decline: the ARIC 14-year follow-up study. Neurology, 73:862-868, 2009, PMC2744282.

33.   Knopman DS, Kramer JH, Boeve BF, Caselli RJ, Graff-Radford NR, Mendez MF, Miller BL, Mercaldo N. Development of methodology for conducting clinical trials in frontotemporal lobar degeneration. Brain, 131:2957-2968, 2008, PMC2667989.

34.   Boeve BF, Silber MH, Saper CB, Ferman TJ, Dickson DW, Parisi JE, Benarroch EE, Ahlskog JE, Smith GE, Caselli RC, Tippman-Peikert M, Olson EJ, Lin SC, Young T, Wszolek Z, Schenck CH, Mahowald MW, Castillo PR, Del Tredici K, Braak H. Pathophysiology of REM sleep behaviour disorder and relevance to neurodegenerative disease. Brain, 130:2770-2788, 2007.

35.   Boeve BF. Parkinson-related dementias. Neurol Clin, 25:761-781, 2007.

36.   Knopman DS, Boeve BS, Caselli RJ, Graff-Radford NR, Kramer JH, Mendez MF, Miller BL. Longitudinal tracking of FTLD: toward developing clinical trial methodology. Alzheimer Dis Assoc Disord, 21:S58-63, 2007.

37.   Boeve BF. A review of the non-Alzheimer dementias. J Clin Psychiatry, 67:1985-2001, 2006.

38.   Gass J, Cannon A, Mackenzie IR, Boeve B, Baker M, Adamson J, Crook R, Melquist S, Kuntz K, Petersen R, Josephs K, Pickering-Brown SM, Graff-Radford N, Uitti R, Dickson D, Wszolek Z, Gonzalez J, Beach TG, Bigio E, Johnson N, Weintraub S, Mesulam M, White CL, 3rd, Woodruff B, Caselli R, Hsiung GY, Feldman H, Knopman D, Hutton M, Rademakers R. Mutations in progranulin are a major cause of ubiquitin-positive frontotemporal lobar degeneration. Hum Mol Genet, 15:2988-3001, 2006.

39.   Josephs KA, Petersen RC, Knopman DS, Boeve BF, Whitwell JL, Duffy JR, Parisi JE, Dickson, DW. Clinicopathologic analysis of frontotemporal and corticobasal degenerations and PSP. Neurology, 66:41-48, 2006.

40.   Knopman DS, Boeve BF, Parisi JE, Dickson DW, Smith GE, Ivnik RJ, Josephs KA, Petersen RC. Antemortem diagnosis of frontotemporal lobar degeneration. Ann Neurol, 57:480-488, 2005.


   Principal Investigator: Thomas Montine, MD, PhD
   Title: Characterization of DLB: A Collaborative Study
   Agency: NIA - RO1 NS048595
   Date Funded: 9/1/2003
 
       Publications
41.   Wang LY, Leverenz JB, Larson EB, Vavrek DA, Kukull WA, McCormick W, Bowen JD, Teri L, Montine T, Tsuang DW. Cognitive impairment in older adults without dementia: clinical and pathologic outcomes in a community-based sample. J Geriatr Psychiatry Neurol, 22:256-265, 2009, PMC2783244.

42.   Bekris LM, Millard SP, Galloway NM, Vuletic S, Albers JJ, Li G, Galasko DR, DeCarli C, Farlow MR, Clark CM, Quinn JF, Kaye JA, Schellenberg GD, Tsuang D, Peskind ER, Yu CE. Multiple SNPs within and surrounding the apolipoprotein E gene influence cerebrospinal fluid apolipoprotein E protein levels. J Alzheimers Dis, 13:255-266, 2008, PMC3192652.

43.   Leverenz JB, Hamilton RL, Tsuang DW, Schantz A, Vavrek D, Larson EB, Kukull WA, Lopez OL, Galasko D, Masliah E, Kaye J, Nixon R, Clark C, Trojanowski J, Montine TJ. Empiric refinement of the pathologic assessment of Lewy-related pathology in the dementia patient. Brain Pathol, 18:220-224, 2008, PMC2689097.

44.   VanRollins M, Woltjer RL, Yin H, Morrow JD, Montine TJ. F2-dihomo-isoprostanes arise from free radical attack on adrenic acid. J Lipid Res, 49:995-1005, 2008, PMC2311438.

45.   Leverenz JB, Umar I, Wang Q, Montine TJ, McMillan PJ, Tsuang DW, Jin J, Pan C, Shin J, Zhu D, Zhang J. Proteomic identification of novel proteins in cortical lewy bodies. Brain Pathol, 17:139-145, 2007.

46.   Sonnen JA, Larson EB, Crane PK, Haneuse S, Li G, Schellenberg GD, Craft S, Leverenz JB, Montine TJ. Pathological correlates of dementia in a longitudinal, population-based sample of aging. Ann Neurol, 62:406-413, 2007.

47.   Yang W, Woltjer RL, Sokal I, Pan C, Wang Y, Brodey M, Peskind ER, Leverenz JB, Zhang J, Perl DP, Galasko DR, Montine TJ. Quantitative proteomics identifies surfactant-resistant alpha-synuclein in cerebral cortex of Parkinsonism-dementia complex of Guam but not Alzheimer's disease or progressive supranuclear palsy. Am J Pathol, 171:993-1002, 2007, PMC1959487.

48.   Abdi F, Quinn JF, Jankovic J, McIntosh M, Leverenz JB, Peskind E, Nixon R, Nutt J, Chung K, Zabetian C, Samii A, Lin M, Hattan S, Pan C, Wang Y, Jin J, Zhu D, Li GJ, Liu Y, Waichunas D, Montine TJ, Zhang J. Detection of biomarkers with a multiplex quantitative proteomic platform in cerebrospinal fluid of patients with neurodegenerative disorders. J Alzheimers Dis, 9:293-348, 2006.

49.   Leverenz JB, Fishel MA, Peskind ER, Montine TJ, Nochlin D, Steinbart E, Raskind MA, Schellenberg GD, Bird TD, Tsuang D. Lewy body pathology in familial Alzheimer disease - Evidence for disease- and mutation-specific pathologic phenotype. Arch Neurol, 63:370-376, 2006, PMC1892620.

50.   Tsuang DW, Riekse RG, Purganan KM, David AC, Montine TJ, Schellenberg GD, Steinbart EJ, Petrie EC, Bird TD, Leverenz JB. Lewy body pathology in late-onset familial Alzheimer's disease: A clinicopathological case series. J Alzheimers Dis, 9:235-242, 2006.

51.   Zabetian CP, Lauricella CJ, Tsuang DW, Leverenz JB, Schellenberg GD, Payami H. Analysis of the LRRK2 G2019S mutation in Alzheimer Disease. Arch Neurol, 63:156-157, 2006.

52.   Zaja-Milatovic S, Keene CD, Montine KS, Leverenz JB, Tsuang D, Montine TJ. Selective dendritic degeneration of medium spiny neurons in dementia with Lewy bodies. Neurology, 66:1591-1593, 2006.

53.   Kraybill ML, Larson EB, Tsuang DW, Teri L, McCormick WC, Bowen JD, Kukull WA, Leverenz JB, Cherrier MM. Cognitive differences in dementia patients with autopsy-verified AD, Lewy body pathology, or both. Neurology, 64:2069-2073, 2005, PMC1513627.

54.   Tsuang D, Simpson KL, Li G, Barnhart RL, Edland SD, Bowen J, McCormick W, Teri L, Nochlin D, Larson EB, Thompson ML, Leverenz JB. Evaluation of selection bias in an incident-based dementia autopsy case series. Alzheimer Dis Assoc Disord, 19:67-73, 2005, PMC1524825.

55.   Tsuang DW, Wilson RK, Lopez OL, Luedecking-Zimmer EK, Leverenz JB, DeKosky ST, Kamboh MI, Hamilton RL. Genetic association between the APOE*4 allele and Lewy bodies in Alzheimer disease. Neurology, 64:509-513, 2005, PMC1487185.

56.   Ohtake H, Limprasert P, Fan Y, Onodera O, Kakita A, Takahashi H, Bonner LT, Tsuang DW, Murray IV, Lee VM, Trojanowski JQ, Ishikawa A, Idezuka J, Murata M, Toda T, Bird TD, Leverenz JB, Tsuji S, La Spada AR. Beta-synuclein gene alterations in dementia with Lewy bodies. Neurology, 63:805-811, 2004, PMC1808539.

57.   Riekse RG, Leverenz JB, McCormick W, Bowen JD, Teri L, Nochlin D, Simpson K, Eugenio C, Larson EB, Tsuang D. Effect of vascular lesions on cognition in Alzheimer's disease: a community-based study. J Am Geriatr Soc, 52:1442-1448, 2004, PMC1487184.

58.   Tsuang DW, DiGiacomo L, Bird TD. Familial occurrence of dementia with Lewy bodies. Am J Geriatr Psychiatry, 12:179-188, 2004, PMC1482839.

59.   Bonner LT, Tsuang DW, Cherrier MM, Eugenio CJ, Du Jennifer Q, Steinbart EJ, Limprasert P, La Spada AR, Seltzer B, Bird TD, Leverenz JB. Familial dementia with Lewy bodies with an atypical clinical presentation. J Geriatr Psychiatry Neurol, 16:59-64, 2003.


   Principal Investigator: Patricia L, Kramer
   Title: Genetic Associations with Alzheimer-free Survival
   Agency: NIA - RO1 AG026916
   Date Funded: 7/1/2005
 
       Publications
60.   Kramer PL, Xu H, Woltjer RL, Westaway SK, Clark D, Erten-Lyons D, Kaye JA, Welsh-Bohmer KA, Troncoso JC, Markesbery WR, Petersen RC, Turner RS, Kukull WA, Bennett DA, Galasko D, Morris JC, Ott J. Alzheimer disease pathology in cognitively healthy elderly: A genome-wide study. Neurobiol Aging, 32:2113-22, 2011, PMC2990809.

61.   Kruer MC, Koch TK, Bourdette DN, Chabas D, Waubant E, Mueller S, Moscarello MA, Dalmau J, Woltjer RL, Adamus G. NMDA receptor encephalitis mimicking seronegative neuromyelitis optica. Neurology, 74:1473-1475, 2010, PMC2872802.

62.   Shervais S, Kramer PL, Westaway SK, Cox NJ, Zwick M. Reconstructability analysis as a tool for identifying gene-gene interactions in studies of human diseases. Stat Appl Genet Mol Biol, 9:Article 18, 2010, PMC2861311.

63.   Wang G, Yang Y, Ott J. Genome-wide conditional search for epistatic disease-predisposing variants in human association studies. Hum Hered, 70:34-41, 2010, PMC2912644.

64.   Hayes TL, Cobbinah K, Dishongh T, Kaye JA, Kimel J, Labhard M, Leen T, Lundell J, Ozertem U, Pavel M, Philipose M, Rhodes K, Vurgun S. A study of medication-taking and unobtrusive, intelligent reminding. Telemed J E Health, 15:770-776, 2009, PMC2998278.


   Principal Investigator: Daniel H. Geschwind
   Title: Identification of Novel Genetic Risk Factors for AD and FTD
   Agency: NIA - RO1 AG026938
   Date Funded: 9/1/2005
 
       Publications
65.   Coppola G, Wang Q, Davis-Turak J, Lee JJ, Klein E, Huang A, Rasheedi K, Karydas A, Rosen A, Varpetian A, Miller J, Poon W, LeBer I, Shapira J, Faber K, Beekly D, Cotman C, DeCarli C, Ringman J, Mendez M, Brice A, Foroud T, Kukull W, Chui H, Levey A, Miller B, Geschwind G. Genetic Investigation in Frontotemporal Dementia and Alzheimer's Disease: the GIFT Study. Dement Geriatr Cogn Disord, 30:50, 2010. (Abstract)

66.   Coppola G, Miller B, Levey A, Varpetian A, Chui H, DeCarli C, Cotman C, Bartzokis G, Mendez M, Kukull W, Foroud T, Geschwind D. Genetic investigation in frontotemporal dementia and Alzheimer's disease: The GIFT study. Neurology, 70:A242, 2008. (Abstract)

67.   Coppola G, Miller BL, Chui H, Varpetian A, Levey A, Cotman CW, DeCarli C, Mendez MF, Bartzokis G, Kukull WA, Foroud T, Geschwind DH. Genetic investigation in frontotemporal dementia and Alzheimer's disease: The GIFT study. Ann Neurol, 62:S525, 2007. (Abstract)

68.   Chen JA, Wang Q, Davis-Turak J, Li Y, Karydas AM, Hsu SC, Sears RL, Chatzopoulou D, Huang AY, Wojta KJ, Klein E, Lee J, Beekly DL, Boxer A, Faber KM, Haase CM, Miller J, Poon WW, Rosen A, Rosen H, Sapozhnikova A, Shapira J, Varpetian A, Foroud TM, Levenson RW, Levey AI, Kukull WA, Mendez MF, Ringman J, Chui H, Cotman C, DeCarli C, Miller BL, Geschwind DH, Coppola G. A multiancestral genome-wide exome array study of Alzheimer disease, frontotemporal dementia, and progressive supranuclear palsy. JAMA Neurol, 72:414-422, 2015, PMC4397175.

69.   Miller JA, Horvath S, Geschwind DH. Divergence of human and mouse brain transcriptome highlights Alzheimer disease pathways. Proc Natl Acad Sci U S A, 107:12698-12703, 2010, PMC2906579.

70.   Coppola G, Karydas A, Rademakers R, Wang Q, Baker M, Hutton M, Miller BL, Geschwind DH. Gene expression study on peripheral blood identifies progranulin mutations. Ann Neurol, 64:92-96, 2008, PMC2773201.

71.   Miller JA, Oldham MC, Geschwind DH. A systems level analysis of transcriptional changes in Alzheimer's disease and normal aging. J Neurosci, 28:1410-1420, 2008, PMC2902235.

72.   Rademakers R, Baker M, Gass J, Adamson J, Huey ED, Momeni P, Spina S, Coppola G, Karydas AM, Stewart H, Johnson N, Hsiung GY, Kelley B, Kuntz K, Steinbart E, Wood EM, Yu CE, Josephs K, Sorenson E, Womack KB, Weintraub S, Pickering-Brown SM, Schofield PR, Brooks WS, Van Deerlin VM, Snowden J, Clark CM, Kertesz A, Boylan K, Ghetti B, Neary D, Schellenberg GD, Beach TG, Mesulam M, Mann D, Grafman J, Mackenzie IR, Feldman H, Bird T, Petersen R, Knopman D, Boeve B, Geschwind DH, Miller B, Wszolek Z, Lippa C, Bigio EH, Dickson D, Graff-Radford N, Hutton M. Phenotypic variability associated with progranulin haploinsufficiency in patients with the common 1477C-->T (Arg493X) mutation: an international initiative. Lancet Neurol, 6:857-868, 2007.

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1.   Donovan NJ, Amariglio RE, Zoller AS, Rudel RK, Gomez-Isla T, Blacker D, Hyman BT, Locascio JJ, Johnson KA, Sperling RA, Marshall GA, Rentz DM. Subjective Cognitive Concerns and Neuropsychiatric Predictors of Progression to the Early Clinical Stages of Alzheimer Disease. Am J Geriatr Psychiatry, 22:1642-1651, 2014, PMC4145054.

2.   Fargo KN, Aisen P, Albert M, Au R, Corrada MM, DeKosky S, Drachman D, Fillit H, Gitlin L, Haas M, Herrup K, Kawas C, Khachaturian AS, Khachaturian ZS, Klunk W, Knopman D, Kukull WA, Lamb B, Logsdon RG, Maruff P, Mesulam M, Mobley W, Mohs R, Morgan D, Nixon RA, Paul S, Petersen R, Plassman B, Potter W, Reiman E, Reisberg B, Sano M, Schindler R, Schneider LS, Snyder PJ, Sperling RA, Yaffe K, Bain LJ, Thies WH, Carrillo MC. 2014 Report on the Milestones for the US National Plan to Address Alzheimer's Disease. Alzheimers Dement, 10:S430-452, 2014.

3.   Chou SH, Shulman JM, Keenan BT, Secor EA, Buchman AS, Schneider J, Bennett DA, De Jager PL. Genetic susceptibility for ischemic infarction and arteriolosclerosis based on neuropathologic evaluations. Cerebrovascular Disease, 36:181-188, 2013, PMC3871868.

4.   Khachaturian AS, Meranus DH, Kukull WA, Khachaturian ZS. Big data, aging, and dementia: pathways for international harmonization on data sharing. Alzheimers and Dementia, 9:S61-62, 2013.

5.   Lu PH, Mendez MF, Lee GJ, Leow AD, Lee HW, Shapira J, Jimenez E, Boeve BB, Caselli RJ, Graff-Radford NR, Jack CR, Kramer JH, Miller BL, Bartzokis G, Thompson PM, Knopman DS.. Patterns of brain atrophy in clinical variants of frontotemporal lobar degeneration. Dement Geriatr Cogn Disord, 35:34-50, 2013, PMC3609420.

6.   McDavid A, Crane PK, Newton KM, Crosslin DR, McCormick W, Weston N, Ehrlich K, Hart E, Harrison R, Kukull WA, Rottscheit C, Peissig P, Stefanski E, McCarty CA, Zuvich RL, Ritchie MD, Haines JL, Denny JC, Schellenberg GD, de Andrade M, Kullo I, Li R, Mirel D, Crenshaw A, Bowen JD, Li G, Tsuang D, McCurry S, Teri L, Larson EB, Jarvik GP, Carlson CS. Enhancing the Power of Genetic Association Studies through the Use of Silver Standard Cases Derived from Electronic Medical Records. PLoS ONE, 8:e63481, 2013, PMC3677889.

7.   Shulman JM, Chen K, Keenan BT, Chibnik LB, Fleisher A, Thiyyagura P, Roontiva A, McCabe C, Patsopoulos NA, Corneveaux JJ, Yu L, Huentelman MJ, Evans DA, Schneider JA, Reiman EM, De Jager PL, Bennett DA. Genetic susceptibility for Alzheimer disease neuritic plaque pathology. JAMA Neurology, 70:1150-1157, 2013, PMC3773291.

8.   De Jager PL, Shulman JM, Chibnik LB, Keenan BT, Raj T, Wilson RS, Yu L, Leurgans SE, Tran D, Aubin C, Anderson CD, Biffi A, Corneveaux JJ, Huentelman MJ, Rosand J, Daly MJ, Myers AJ, Reiman EM, Bennett DA, Evans DA. A genome-wide scan for common variants affecting the rate of age-related cognitive decline. Neurobiol Aging, 33:1017 e1011-1015, 2012, PMC3307898.

9.   Hamilton G, Killick R, Lambert JC, Amouyel P, Carrasquillo MM, Pankratz VS, Graff-Radford NR, Dickson DW, Petersen RC, Younkin SG, Powell JF, Wade-Martins R. Functional and genetic analysis of haplotypic sequence variation at the nicastrin genomic locus. Neurobiol Aging, 33:1848 e1-e13, 2012, PMC3683320.

10.   Keenan BT, Shulman JM, Chibnik LB, Raj T, Tran D, Sabuncu MR, Allen AN, Corneveaux JJ, Hardy JA, Huentelman MJ, Lemere CA, Myers AJ, Nicholson-Weller A, Reiman EM, Evans DA, Bennett DA, De Jager PL. A coding variant in CR1 interacts with APOE-epsilon4 to influence cognitive decline. Hum Mol Genet, 21:2377-2388, 2012, PMC3335317.

11.   Lim AS, Chang AM, Shulman JM, Raj T, Chibnik LB, Cain SW, Rothamel K, Benoist C, Myers AJ, Czeisler CA, Buchman AS, Bennett DA, Duffy JF, Saper CB, De Jager PL. A common polymorphism near PER1 and the timing of human behavioral rhythms. Ann Neurol, 72:324-334, 2012, PMC3464954.

12.   Schmitt FA, Nelson PT, Abner E, Scheff S, Jicha GA, Smith C, Cooper G, Mendiondo M, Danner DD, Van Eldik LJ, Caban-Holt A, Lovell MA, Kryscio RJ. University of Kentucky Sanders-Brown healthy brain aging volunteers: donor characteristics, procedures and neuropathology. Curr Alzheimer Res, 9:724-733, 2012, PMC3409295.

13.   Swaminathan S, Huentelman MJ, Corneveaux JJ, Myers AJ, Faber KM, Foroud T, Mayeux R, Shen L, Kim S, Turk M, Hardy J, Reiman EM, Saykin AJ. Analysis of copy number variation in Alzheimer's disease in a cohort of clinically characterized and neuropathologically verified individuals. PLoS ONE, 7:e50640, 2012, PMC3515604.

14.   Brookmeyer R, Evans DA, Hebert L, Langa KM, Heeringa SG, Plassman BL, Kukull WA. National estimates of the prevalence of Alzheimer's disease in the United States. Alzheimers and Dementia+D310, 7:61-73, 2011, PMC3052294.

15.   Khachaturian ZS, Petersen RC, Snyder PJ, Khachaturian AS, Aisen P, de Leon M, Greenberg BD, Kukull W, Maruff P, Sperling RA, Stern Y, Touchon J, Vellas B, Andrieu S, Weiner MW, Carrillo MC, Bain LJ. Developing a global strategy to prevent Alzheimer's disease: Leon Thal Symposium 2010. Alzheimers and Dementia, 7:127-132, 2011.

16.   Gilman S, Koeppe RA, Nan B, Wang CN, Wang X, Junck L, Chervin RD, Consens F, Bhaumik A. Cerebral cortical and subcortical cholinergic deficits in parkinsonian syndromes. Neurology, 74:1416-1423, 2010, PMC2871002.

17.   Li G, Shofer JB, Rhew IC, Kukull WA, Peskind ER, McCormick W, Bowen JD, Schellenberg GD, Crane PK, Breitner JC, Larson EB. Age-varying association between statin use and incident Alzheimer's disease. J Am Geriatr Soc, 58:1311-1317, 2010, PMC3176730.

18.   Roe CM, Mintun MA, Ghoshal N, Williams MM, Grant EA, Marcus DS, Morris JC. Alzheimer disease identification using amyloid imaging and reserve variables: proof of concept. Neurology, 75:42-48, 2010, PMC2906402.

19.   Lopez, OL, Becker JT, Wahed AS, Saxton J, Sweet RA, Wolk DA, Klunk W, Dekosky ST. Long-term effects of the concomitant use of memantine with cholinesterase inhibition in Alzheimer disease. J Neurol Neurosurg Psychiatry, 80:600-607, 2009, PMC2823571.

20.   Salloway S, Sperling R, Gilman S, Fox NC, Blennow K, Raskind M, Sabbagh M, Honig LS, Doody R, van Dyck CH, Mulnard R, Barakos J, Gregg KM, Liu E, Lieberburg I, Schenk D, Black R, Grundman M. A phase 2 multiple ascending dose trial of bapineuzumab in mild to moderate Alzheimer disease. Neurology, 73:2061-2070, 2009, PMC2790221.

21.   Mukherjee O, Wang J, Gitcho M, Chakraverty S, Taylor-Reinwald L, Shears S, Kauwe JS, Norton J, Levitch D, Bigio EH, Hatanpaa KJ, White CL, Morris JC, Cairns NJ, Goate A. Molecular characterization of novel progranulin (GRN) mutations in frontotemporal dementia. Hum Mutat, 29:512-521, 2008, PMC2756561.

22.   Mackenzie IR, Bigio EH, Ince PG, Geser F, Neumann M, Cairns NJ, Kwong LK, Forman MS, Ravits J, Stewart H, Eisen A, McClusky L, Kretzschmar HA, Monoranu CM, Highley JR, Kirby J, Siddique T, Shaw PJ, Lee VM, Trojanowski JQ. Pathological TDP-43 distinguishes sporadic amyotrophic lateral sclerosis from amyotrophic lateral sclerosis with SOD1 mutations. Ann Neurol, 61:427-434, 2007.

23.   Li G, Shofer JB, Kukull WA, Peskind ER, Tsuang DW, Breitner JC, McCormick W, Bowen JD, Teri L, Schellenberg GD, and Larson EB. Serum cholesterol and risk of Alzheimer disease: a community-based cohort study. Neurology, 65:1045-1050, 2005.

24.   Rosenberg RN. Translational research on the way to effective therapy for Alzheimer disease. Arch Gen Psychiatry, 62:1186-1192, 2005.

25.   Crane PK, van Belle G, Larson EB. Test bias in a cognitive test: differential item functioning in the CASI. Stat Med, 23:241-256, 2004.

26.   Li G, Higdon R, Kukull WA, Peskind E, Van Valen Moore K, Tsuang D, van Belle G, McCormick W, Bowen JD, Teri L, Schellenberg GD, Larson EB. Statin therapy and risk of dementia in the elderly: a community-based prospective cohort study. Neurology, 63:1624-1628, 2004.



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