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The National Alzheimer's Coordinating Center was established by the National Institute on Aging/NIH (U01 AG016976) in 1999 to facilitate collaborative research. Using data collected from the NIA-funded Alzheimer's Disease Centers (ADCs) across the United States, NACC has developed and maintains a large relational database of standardized clinical and neuropathological research data. In partnership with the Alzheimer's Disease Genetics Consortium (ADGC), the National Cell Repository for Alzheimer's Disease (NCRAD), and the NIA Genetics of Alzheimer's Disease Data Storage Site (NIAGADS), NACC provides a valuable resource for both exploratory and explanatory Alzheimer's disease research. NACC data are freely available to all researchers.